Báo cáo y học: "Asporin, a susceptibility gene in osteoarthritis, is expressed at higher levels in the more degenerate human intervertebral disc" ppsx

... Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S: An aspartic acid repeat poly- morphism ... analysis in disc as was reported by Kizawa et al. [4] in cartilage. Another shortcoming is that we were not able to carry out a complete analysis of the localization of asporin...

Ngày tải lên: 09/08/2014, 14:20

... specifically control the PGE 2 synthesis asso- ciated with inflammation in patients with OA and other inflammatory diseases. Conclusion mPGES-1 was upregulated by proinflammatory cytokines in OA chondrocytes ... 485 ATG CAG CCT GCT TCT GCA AA CCT TAC TCC AGA TCT GGC AT 30 COX-1 401 CTT TCT CCA ACG TGA GCT ATT GTG CAT CAA CAC AGG CGC CTC TTC 32 COX-2 1157 AGA CAG ATC ATA AGC GAG GGC C...

Ngày tải lên: 09/08/2014, 01:23

... to mannan (data not shown). Assessment of MBL pathway activation MBL pathway activation was assessed by an enzyme-linked immunosorbent assay technique that measures the complete MBL pathway activity ... pathway in this assay, an antibody against C1q is added to the reaction mixture [23]. Functional activity of the MBL pathway was expressed as percentage of a standard consisting...

Ngày tải lên: 09/08/2014, 08:23

... Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K: Functional haplotypes of Arthritis Research ... 5 PADI4, encoding citrullinating enzyme peptidylarginine deimi- nase 4, are associated with rheumatoid arthritis. Nat Genet 2003, 34:395-402. 8. Nakashima K, Hagiwara T, Yamada M: Nucl...

Ngày tải lên: 09/08/2014, 01:23

... advanced OA. In contrast to general- ized arterial calcification of infancy, in which hydroxyapatite crystals are formed, calcium pyrophosphate dihydrate crystal deposition is observed in these patients ... hand OA in a large sample of Caucasian nuclear families. We focused our attention on a relatively isolated population in southern Russia, the Chuvashians. They live in...

Ngày tải lên: 09/08/2014, 06:23

... thus the recall bias may affect the accuracy of information gathered. Finally, vitamin D intake was not assessed in our population. Despite these limitations, the present findings are not antici- pated ... she was classified as having finger OA. Symmetrical OA was defined as a subcategory of OA in at least two symmetrical pairs of the joints (if two joints of the hand are af...

Ngày tải lên: 09/08/2014, 07:20

... 2005, 310:644-648. 24. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H: ... validation of the fusion candidate. All validated fusions in this data set have breakpoints lying at the exon boundary. This might indicate that, in case of geno...

Ngày tải lên: 09/08/2014, 22:23

... Access ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data Brad A Friedman 1,2,3* and Tom Maniatis 4 Abstract RNA-Seq and microarray platforms have ... looking at the distribution of the whole set, the event_heatmap tool visualizes the individual levels or fold-change of all the genes in the set as a heatmap (Figure 6c)....

Ngày tải lên: 09/08/2014, 23:20

... National Academy of Sciences of the United States of America 2004, 101:6062–7. 15. Ihaka R, Gentleman R: R: A Language for Data Analysis and Graphics. Journal of Computational and Graphical Statistics ... performance against alternative approaches. In all cases, SpeCond displayed higher sensitivity and a lower false discovery rate. Importantly, the SpeCond package is not a...

Ngày tải lên: 09/08/2014, 23:20

... between hypoalbu- minemia and CVD is the reflection of inflammation induced malnutrition. The underlying mechanism be- hind this includes appetite suppression and increased catabolism by inflammatory ... hypoalbuminaemia is an independent predictor of CVD in early CKD stages; b) hypoalbu- minaemia may be used to identify the population at higher risk for CVD. Key words: Hyp...

Ngày tải lên: 03/11/2012, 11:52