... GSK3 by lithium in the context of circadian rhythms is hardly a panacea for the therapy of affective mood disorders. Nevertheless, (i) the cyclical and episodic nature of BPD symptoms, (ii) the prevalence ... depletion of GSK3 in synchronized oscillating MEFsresults in a significant delay in the periodicity of the endogenous clock mechanism,particularly in the cycling period of mPer2. Furthermore, ... mixture of penicillin-streptomycin-glutamine (PSG from GIBCO). Puromycin-resistant MEFlines were grown, maintained, serum shocked, and serumstarved in medium containing 2 µg/mL puromycin.Where indicated,...