Báo cáo y học: "Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13" docx

... an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in carti- lage chondrocytes. ... good quality of life. Consequently, the challenge of improving the ACL: anterior cruciate ligament; ASU: avocado/soybean unsaponifiables; iNOS: inducible n...

Ngày tải lên: 09/08/2014, 14:20

... AG18393. The study sponsor was not involved in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper ... by chondrocytes, synovial cells, and other cells of the skeleton. Its synthesis is increased in chondrocytes and in synovial cells when activated by proin- f...

Ngày tải lên: 09/08/2014, 10:21

... protein and is part of the nuclear chromatin whereas the second half of the fusion protein, the KRED produces highly reactive radicals inducing damages [31] in the sur- rounding proteins and ... to mark the broken DNA and to analyse the type and number of genes involved.We also like to analyse the genes present in the periphery of the nuclei in d...

Ngày tải lên: 25/10/2012, 11:15

... synthetase, inhibition of CoA-IT results in an increase in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells with CoA-synthetase inhibitors ... (1973) The enzymic incorporation of arachidonic acid into ether-containing choline and ethanolamine phosphoglycerides by deacylation-acylation reactions. Biochim. Bioph...

Ngày tải lên: 22/02/2014, 07:20

... post-translational modifications on heparin binding, recombinant CHO cells were treated with inhibitors of tyrosine s ulfation and N-glycosylation under conditions that allowed partial inhibition of these modifications. ... medium containing the same concentration of the glycosylation inhibitor w as added. Three days later, the conditioned medium was harvested and inspected...

Ngày tải lên: 08/03/2014, 22:20

... fragmentation (Fig. 7B). On the basis of the intensity of bands, the protective activity follows the sequence of EM1 > GSH > EM2. Inhibition of REM by EM1 and EM2 Using the same sample solutions ... spectroscopy since the primary peroxidation Fig. 8. Inhibition of the increase in REM of LDL during the Cu 2+ -induced (A) or AAPH-initiated (B) peroxid...

Ngày tải lên: 23/03/2014, 10:21

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Ngày tải lên: 07/08/2014, 17:22

... of glycosaminoglycan release and nitric oxide production, and induction of fibrogenesis and muscle edema. In addition, induction of chondrogenesis within the synovial lining was observed. These results ... effects of IL-1β on matrix metabolism [21,25]. Inhibition of white blood cell infiltration and elevation of nitric oxide synthesis To determine wheth...

Ngày tải lên: 09/08/2014, 01:21

... grey) and M2139 (dark grey) over the course of 21 days. (b) The number of empty chondrons expressed as a percentage of the total number of chondrons, indicating the loss of chondrocyte from the ... hypertrophy and there was a measurable increase in the proportion of empty chondrons. Notably, the non-arthritogenic mAb CIIF4 induced none of these changes....

Ngày tải lên: 09/08/2014, 06:23

... RT-PCR of the enzymes involved in the synthesis of these mediators (cyclooxygenase-2 (COX-2) and inducible Figure 1 Cytokine circulating levels in mice at the end of treatment in the collagen-induced ... is expressed by a variety of cell types involved in RA, including activated T cells and synoviocytes [8]. These cells, in the pres- ence of cytokines like TN...

Ngày tải lên: 09/08/2014, 06:23