Báo cáo y học: "Microparticle-induced release of B-lymphocyte regulators by rheumatoid synoviocytes" ppsx

... provoked by systemic autoimmunity. Ryu- machi 1997, 37:147. 33. Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D: Organ-specific disease provoked by systemic autoimmunity. Cell ... formation of immune complexes, by activation of complement, thereby recruiting cells into the synovium. Although preliminary data suggested that patients who are RF negative appear les...

Ngày tải lên: 09/08/2014, 10:20

... ‘molecular synovectomy’ (either by expression of herpes simplex virus-thymidine kinase with subsequent administration of ganciclovir or by overexpression of Fas-ligand/inhibitors of nuclear translocation ... http://arthritis-research.com/articles/ review-series.asp?series=ar_Cells monocytes by ligation of major histocompatibility complex-II, with subsequent enhancement of p...

Ngày tải lên: 09/08/2014, 10:22

... Hakansson,K.,Doherty,A.J.,Shuman,S.&Wigley,D.B.(1997) X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell 89,545– 553. 31. Doherty, A.J., ... similarly to the motif at the 3¢-OH primer end of the dsDNA bound to DNA polymerase. What could be the role of this transition in the DNA ligase catalysis? DYNAMIC MECHANISM OF NIC...

Ngày tải lên: 21/02/2014, 01:21

... of Bioscience and Biotechnology, Faculty of Engineering, Graduate School of Natural Science and Technology, Okayama University, Japan; 2 Department of Biology, Faculty of Sciences, University ... rowth-inhibitory eect was also attenuated by this modi®cation. These results suggest that growth inhibition by ECP is dependent on cell type and is cytostatic. Keywords: cell cycle; co...

Ngày tải lên: 17/03/2014, 17:20

... telomerase activity was measured by TRAP/EIA cells 3 days later. (C) Telomerase activity after introduction of antisense oligonucleotides into PHA- stimulated lymphocytes. Ficoll-Hypaque isolated lymphocytes ... inhibition of TEP1 function by high concentra- tions of antisense oligonucleotides, telomerase activity was dramatically diminished. Alternatively, hTR and hTERT may play a...

Ngày tải lên: 17/03/2014, 23:20

... Identification of human semaphorin E gene expres- sion in rheumatoid synovial cells by mRNA differential display. Biochem Biophys Res Commun 1997, 234:153-156. 16. Seki T, Selby J, Haupl T, Winchester ... MG, Kennedy TC, Kempsell KE: Analysis of immune system gene expression in small rheumatoid arthritis biopsies using a combination of subtractive hybridization and high-density cD...

Ngày tải lên: 09/08/2014, 06:22

... expression of TLR3 by murine but not human macrophages (Table 2); the expression of TLR8 by human but not murine myeloid dendritic cells; and the expression of TLR9 by murine but not human myeloid ... expression of type I IFNs, a major component of antiviral immunity [44]. TLR9 signalling through MyD88 by plasmacytoid dendritic cells can also produce high amounts of type I...

Ngày tải lên: 09/08/2014, 07:20

... antibody, in the synovial tissue of nine patients with rheumatoid arthritis before and after treatment with infliximab. The percentage of positively stained tis- sue area, analysed by computerized ... pro-inflammatory cytokines may be of importance in the pathogenesis of RA and as possible targets for therapy. In this study we investigated the effect of TNF blockade (inflixima...

Ngày tải lên: 09/08/2014, 07:20

... presented by medullary APC, which include medullary epithelial cells and medullary DC, are deleted by negative selection above a threshold of affinity for self-antigens presented by those APC ... disease of RA driven by similar and simultaneous triggers to NF-κB. Introduction Rheumatoid arthritis (RA) is characterized by systemic and synovial tissue chronic inflammation, and...

Ngày tải lên: 09/08/2014, 10:20

... chondrocytes may not only participate in the destruction of the cartilage matrix by responding to the proinflammatory cytokines released from the synovium but may themselves also be the source of ... matrix components has offered the possibility of identifying patients at risk for rapid joint damage and also the possibility of early monitoring of the efficacy of disease-modifyin...

Ngày tải lên: 09/08/2014, 10:21