Báo cáo y học: "The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients" pptx

Báo cáo y học: "Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients" doc

... reasonable to hypothesize that the absence of TRAF6/IRAK-1 regulation by miR-146a in RA patients could contribute to the prolonged production of TNF-α that many of these patientsexhibit. Furthermore, ... Female 36 Hydroxychloroquine, prednisone, mycophenolate mofetilSjS1 Female 30 Hydroxychloroquine, mycophenolate mofetilSjS2 Male 21 HydroxychloroquineSSc1 Female 57 Cyclosporine, hydroxychloroquine, ... PBS. The purity of the adherent population was approximately 80%, asdetermined by microscopy. RNA was isolated from the cells,miRNA expression was analyzed by qRT-PCR, and the dataAvailable online...

Báo cáo y học: " Chitosan Interferon-c Nanogene Therapy for Lung Disease: Modulation of T-Cell and Dendritic Cell Immune Responses" pps

... the inflammation of asthma depending on their phenotypeand the presence or absence of specific cytokines. Toexamine the effects of CIN treatment on CD4+Tlymphocyte populations in the lung, sections ... means of supplying therapeutic or prophylacticlevels of an immunomodulatory molecule. Effects of CIN Therapy on T LymphocytesIn a previous study, we found that CIN treatmentsignificantly lowered ... Bankhead-Coley Award and Mabel andEllsworth Simmons Professorship to S.S.M., and by the Joy McCannCulverhouse endowment to the University of South Florida Division of Allergy and Immunology.Correspondence...

... expression/repression decision occurs through asensing system located between the pro moter and the first start codon o f the operon, and depends on interac-tions modulated by a variety of signals. The type of ... attenuator prediction. The most generalapproaches consist of the identification of mutuallyexclusive RNA secondary structures [17,18], with the limitation that they miss non-hairpin anti-terminatorssuch ... fromonegenetoanother(seebelow)argueforthesecondhypothesis.Regulators of the hisS genes: switching between sensingsystemsSyntenic attenuation systems do not necessarily use the same sensing system. There...

Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study" ppsx

... transcription regulation is only one of importance, compartmentalization by pericellular accumula-tion, activation by cleavage of latent pro-enzymes and inhibi-tion by specific proteins being the others ... participation of funds from FEDER (European Union). JR-L is the recipient of a scholarship of the National Program for the Training of University Professors of the Spanish Ministry of Education. AG ... questioning the importance of these six ECM pro-teases in RA. At least two factors moderate a conclusion of this type. The multiplicity of control mechanisms of ECM pro-tease activity, of which...

báo cáo hóa học:" Extensor-tendons reconstruction using autogenous palmaris longus tendon grafting for rheumatoid arthritis patients" pot

... and the synovium over the free ends of the tendons removed using a synovialrongeur. A dorsal synovectomy of the wrist was then com-pleted, and the dorsal bony surfaces inspected for anybone ... flexion but only pas-sive extension of the MP joints. The dynamic splint com-bined with the tendon mobilization program provided the gliding necessary and was easy for the patient to complywith ... proce-dure. Extract the divided end of the tendon through eachsuccessive incision and remove it through the proximalincision. On the basis of the results of the study, good functionaloutcomes can...

Báo cáo y học: "The effects of infliximab therapy on the serum proteome of rheumatoid arthritis patients" pptx

... examine the impact of infliximab therapy on the serum proteome of rheumatoid arthritis patients by means of a massspectrometry-based approach.Methods Sera from 10 patients with rheumatoid arthritis ... properly cited.AbstractIntroduction Although the clinical effects of infliximab therapy in rheumatoid arthritis have been documented extensively, the biological effects of this intervention continue ... inhibition may impact on coagulation proteins, poten-tially independently of its effects on inflammatory pathways. The ultimate impact on the risk of thrombotic events requireslarge longitudinal...

Báo cáo y học: "Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β" docx

... activity of the cyclooxygenases, enzymes that medi-ate the conversion of arachidonic acid to prostaglandins. Asdemonstrated here, however, prostaglandin synthesis onlyaccounts for one of many of ... down-regulates the expression of glucuronosyltransferase I, a key enzymepriming glycosaminoglycan biosynthesis: influence of glu-cosamine on interleukin-1β-mediated effects in ratchondrocytes. Arthritis ... UDP-glucosedehydrogenase and hyaluronan synthase, among others (datanot shown). Effects of IL-1β alone on global expression patterns in chondrocytesIn our assays, IL-1β alone significantly affected the...

Báo cáo y học: "Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13" docx

... reduce the synthesis of the IL-1 receptor antagonist in chondrocytes [38],a process possibly responsible for the enhanced IL-1β effect on these cells. Moreover, the diffusion of NO from the superfi-cial ... present study has limitations largely imposed by the studydesign. One such limitation is the duration of the study (8weeks). A longer study would provide more information on the Figure 4iNOS immunostainingiNOS ... development as well as the protective effect of ASU on the erosion of the calcified cartilage [19]. On the otherhand, ASU were found to have no effect on the level of synthe-sis of other proteases...

Báo cáo y học: "Toxic effects of methoxychlor on the episodic prolactin secretory pattern: Possible mediated effects of nitric oxide production" pdf

... dopamineconcentration, the comparison of values was done by one-way analysis of variance (ANOVA). Finally, to test the existence of an interaction between MTX and TRH, twoways analysis of variance ... terms of NIADDrat PRL-RP3 reference preparation. The sensitivity of the assay was 5 pg/tube. To analyze the variability of the assay, series of plasma of 10 replicates at 4 different con-centrations ... to the control group. This may be explained by a direct effect on the pituitary inducing the reduction of the absoluteamplitude of the prolactin peaks. Also, an indirect effectmediated by the...

Báo cáo y học: "Positioning Effects of KillerRed inside of Cells correlate with DNA Strand Breaks after Activation with Visible Light"

... into the proportionality between the duration of activation and the increase of fluorescence in-tensity inside of the nuclei of DU145 cells. Figure 2 visualizes the degree of the DNA ... were treated with the Poly [ADP-ribose] polymerase (PARP) inhibitor ABT-888 (final concentration 5µM) Recombinatory chemistry of the fusion plasmid The construction of the pKillerRed-Lamin ... restricted to the detection of programmed cell death processes in the therapeutic field like PDT, but they can also contribute to a better understanding of the structure-function rela-tions in the epigenomic...

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