Báo cáo y học: "Hypoxia, hypoxia inducible factor and myeloid cell function" pdf

... consti- tutively following their release from the bone marrow into the Review Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function Sarah R Walmsley 1 , Edwin R Chilvers 2 and Moira KB Whyte 1 1 Academic ... to oxygen deprivation, plays a crucial role in the regulating myeloid cell function in hypoxia and in inflammation more broadly. The roles of HIF in...

Ngày tải lên: 09/08/2014, 13:22

... markers, as they catalyse the conversion of 2,3- oxidosqualene into lanosterol in nonphotosynthetic organ- isms (fungi and mammals), and into cycloartenol and other tetra- and pentacyclic triterpenes ... 3b-(2-dimethylaminoethoxy)- androst-5-en-17-one) [12] was provided by Upjohn Company. 2-(4-chlorophenyl)-D 2 -thiazoline was synthetized as reported previously [13]. m-chloroperbenzoi...

Ngày tải lên: 17/03/2014, 23:20

... growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF), by the lining and stromal cells of the synovium in both conditions. Because hypoxia inducible factor (HIF)-1α and ... Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y: A novel bHLH-PAS factor with close sequence similarity to hypoxia- inducible factor 1 αα regulates t...

Ngày tải lên: 09/08/2014, 01:21

... (4-hydroxy- 3-methoxyphenyl-b-hydroxypropionyl-CoA) into vanillin [28]. An other well known example is trans-o-hydroxy- benzylidenepyruvate hydratase/aldolase [29,30] (also known as is 2¢-hydroxybenzalpyruvate ... activity (A), from P. digitatum and other (B) and (C) hydratase/ aldolase enzymes described in literature. (B1) enoyl-CoA hydratase/ aldolase [26]; (B2) trans-o-hydroxybenzylide...

Ngày tải lên: 21/02/2014, 01:21

... and L -cysteine. Thefilterswerethenrinsedonceinethanol,driedand counted in a scintillation counter (Beckman). Cell cycle analysis and differentiation markers For cell cycle analysis 5 · 10 5 cells ... 3.3-fold and 7.9-fold in eIF2a phosphorylation level in dense and differentiated cells, respectively, compared with logarith- mically growing K562 cells. In summary, growth arrest is...

Ngày tải lên: 22/02/2014, 07:20

... microarrays. YA assisted with data analysis. NY-H assisted with data analysis. KM assisted in microarray data acquirement. NN designed the study, enrolled patients, and assisted with data analysis and ... for excellent secretarial support. References 1. Kotzin BL: Systemic lupus erythematosus. Cell 1996, 85:303-306. 2. Gabay C, Cakir N, Moral F, Roux-Lombard P, Meyer O, Dayer JM, Vische...

Ngày tải lên: 09/08/2014, 01:22

... RA was not much driven by TNF-α activity alone but probably by other cytokines or mechanisms. The heterogeneity in these patterns may be explained by higher disease activity for responders than ... 1. Bioassay for circulating TNF-α bioactivity A functional assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate...

Ngày tải lên: 09/08/2014, 06:22

... type II receptor, recruits and phosphorylates the type I receptor and subsequently activates its receptor Smad, Smad2 or Smad3, by phosphorylation [21]. Thereafter, the phosphorylated Smad2 or Smad3 ... morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially...

Ngày tải lên: 09/08/2014, 07:20

... was analyzed in the synovial lining cells (fibroblast-like and macrophage-like synoviocytes), sub- synovial nonlymphoid mononuclear cells (monocytes, macro- phages, and mast cells), and on endothelial ... by synovial lining cells, nonlym- phoid mononuclear cells, and endothelial cells in the synovium. In addition, we showed that MMP-2 expression by lining cells and nonlymphoid monon...

Ngày tải lên: 09/08/2014, 08:22

... study design, the statistical analysis, and the writing of the manuscript. YY and AO carried out the cell cul- ture experiments. TS prepared the human samples of synovial tissues and cells. YK ... Kochi 2 and Kazuhiko Yamamoto 1 1 Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan 2 Laboratory fo...

Ngày tải lên: 09/08/2014, 08:23