Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" pps

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... for myeloid cell-mediated inflammation and bactericidal capacity of phagocytes, suggesting crosstalk between angiogenesis and inflammation. Review Hypoxia The role...

Ngày tải lên: 09/08/2014, 01:22

... molecular basis of hypoxia tolerance, not only in muscle but also in numerous other diseases (including cancer and RA) and in settings where induction of hypoxia tolerance might be of therapeutic ... contains an evolutionarily conserved LxxLAP consensus motif for hydroxylation by PHD, thus linking two major human signalling systems, namely NF-κB and HIF. Mimicking hyp...

Ngày tải lên: 09/08/2014, 13:22

... important role in the pathogenesis of rheumatoid arthritis (RA) (reviewed in [1]). In the synovial joint, infiltrating T cells are predominantly of the CD4 + pheno- type and are often found in the ... clinical evaluations of patients and manuscript preparation. VM and CT were the principle investigators and participated equally in the planning and coordination...

Ngày tải lên: 09/08/2014, 10:21

... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction. To elucidate the role of the second binding loop of ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total unitary free...

Ngày tải lên: 17/03/2014, 10:20

... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To ... (k cat /K m )forp-hydroxyphenylgly- cine methyl ester and phenylglycine methyl ester that were similar to the wild-type values, whereas the specificity con- stants for p-hydroxyphenyl...

Ngày tải lên: 17/03/2014, 23:20

... indicating that, in the absence of coenzyme M, zinc is probably coordinated by a single sulfur ligand and three oxygen or nitrogen ligands. In the presence of coenzyme M, one (N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In the His237 fi Ala and Cys239 fi Ala mutants, coenzyme M also seemed to bind efficiently by ligation to zinc indicating that so...

Ngày tải lên: 17/03/2014, 23:20

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain (Arg266). The resul...

Ngày tải lên: 18/03/2014, 01:20

... delivery. The frequency of developing atopic dermatitis in the offspring was significantly reduced by 2, 4, and 7 years [26-28], by 50%, 44%, and 36% respectively. Similar studies have yielded ... in Estonian and Swedish infants. Clin Exp Allergy 2005, 35(2):153-9. 12. Bjorksten B, et al.: Allergy development and the intestinal microflora during the first year of life. J Aller...

Ngày tải lên: 08/08/2014, 21:20

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repair, investiga- tors have studied fracture healing in...

Ngày tải lên: 09/08/2014, 01:21

... Anatomy, Physiology and Clinical Medicine in 1878. (c) Title of the manuscript, meaning “The finer changes of joint cartilage in fungous synovitis and caries of the joint-ends”. Fungous synovitis ... consequently lead to increasing inter- est in the role of osteoclasts in local bone erosion that is driven by the hypothesis that synovial pannus makes use Review The role...

Ngày tải lên: 09/08/2014, 01:23