Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf
Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf
... 158),
because there was a decrease in the mean arthritis score after
day 66 in wild-type mice. COMP deficiency led to early onset
of the disease, with a mean onset of arthritis at 37.5 ± 2.81
days in ... low incidence of arthritis, it was not possible to compare
the onset day and the severity of arthritis developed among the
female mice.
Cartilage oligomeric m...
Báo cáo y học: "Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthriti" pptx
... embryos were obtained according to the reg-
ulations of the Ethics Committee of the Medical Faculty of the
University of Göttingen, Germany. The embryos were classi-
fied as follows: three embryos ... hypertrophic chondrocytes along
the edges of the shaft of the diaphysis (Figure 1f).
Western blot and localization of COMP and its mRNA in
healthy and OA hum...
Báo cáo y học: "Bringing order to protein disorder through comparative genomics and genetic interactions" ppsx
... ber of hypotheses regarding
the roles of disorder in protein chaperones, including the
idea that disordered chaperones may directly or indirectly
stabilize client proteins due to their high hydrophilicity, ... a
panel of phenotypes induced by deletion of non-essen-
tial genes and was used directly from the Levy and Sie-
gal study [38].
Multi-functionality
This is simply t...
Báo cáo y học: "T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis" docx
... identify the role played by nonsteroidal anti-inflamma-
tory drugs in the development of CIA.
Clearly, both T-614 and MTX efficiently suppress the CIA
model after the onset of arthritis. Soft tissue ... differentiation in the presence of soluble
IL-6 receptor, thereby contributing to joint destruction and
osteoporosis [46]. IL-17 significantly induces the synthesis...
Báo cáo y học: "Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling" pps
... was assessed. The cartilage of the patella and the tibia
was isolated 3, 7, and 21 days after viral injection and incu-
bated with
35
SO
4
2-
for 3 hours. The proteoglycan synthesis
was found ... purposes)
cytokine-induced and mechanically induced injury. The BMP-
2-induced elevated degradational activity is most likely an
attempt to clear away old matrix molecules to...
Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... extracted S-GAG may be the result of both
newly synthesized proteoglycans and the inhibition of loss of
proteoglycans. However, as presented below, retained prote-
oglycans in the presence of IGF are ... which MMP-2 and MMP-9 are only a subset. On
other occasions, the presence of these gelatinases has been
a valid indication of total MMP activity and thereby the ca...
Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... Chemical Biology Division, Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä,
Finland
5. Division of Rheumatology, Department of Medicine, Pennsylvania State ... activate the single-strand break DNA repair
pathway if applied to host cell DNA. This pathway
was investigated by studying the activity of
Poly(ADP-ribose)Polymerase (PARP),...
Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot
... contraception and hormonal replacement therapy. In
the uterus they oppose the proliferative effect induced by
estrogens and are therefore combined with estrogen in
hormone replacement therapy. The role of ... University of Tampere, Finland;
2
Department of Clinical Chemistry, Tampere
University Hospital, Finland;
3
Department of Anatomy, University of Tampere, Finland
A di...
Báo cáo y học: "Cartilage homeostasis in health and rheumatic diseases" pptx
... maintain their ECM under homeostatic
conditions has remained somewhat of a mystery since they
do not divide and the matrix isolates them from each other,
but gene expression and protein synthesis may ... cytokines are produced in the synovium due to the influx of inflammatory cells
from the circulation and synovial cell hyperplasia. The induction of proinflammatory c...
Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... potentially fatal symptom caused by a
collapse of tracheal rings and bronchi and/ or by inflamma-
tory obstruction of the airways. These patients experience
dyspnea, cough, stridor and (in some ... erosion of cartilage in the nasal
septum is common and occasionally results in the appear-
ance of a ‘saddle-nose’ deformity (Fig. 1). In half of the RP
patients the cart...