... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... thymus, involution, aging, microarray, AGEMAP, thymocytes, caloric restriction Introduction The aging immune system is often characterized by a general decline in the ability to resist infection ... affected dur-ing aging (Table 1B). All of these pathways are in- volved in cell survival [29-33], and deficiencies in the ubiquinone pathway have already been linked to in- creased longevity in mice...