... solubility of fusion proteins is not necessarily indicative of either proper folding or of increased solubility of the protein of interest. We propose that the success of fusion protein systems should ... promoting the solu- bility of polypeptides to which it is fused. Protein Sci. 8, 1668– 1674. 10. Riggs, P. (2000) Expression and purification of recombinant proteins by fus...
Ngày tải lên: 23/03/2014, 21:20
... appears to be anti-inflammatory, limiting and even- tually terminating inflammatory responses by inhibiting synthesis of monocyte and macrophage derived pro-inflamma- tory cytokines [15-19]. IL-10 ... Mi and Paul D Robbins Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA Corresponding author: Paul D Ro...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx
... of hyperlipidemia with statins reduces the probability of a CV event. Introduction The mortality of patients with rheumatoid arthritis (RA) is increased compared with the general population and ... activate an array of proinflammatory genes [18], we predicted an association of this polymorphism with CV events in RA, potentially through a more pronounced inflammatory re...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "What do we know about communicating risk? A brief review and suggestion for contextualising serious, but rare, risk, and the example of cox-2 selective and non-selective NSAIDs" pot
... relative Figure 4 Risk of myopathy, rhabdomyolysis and death from rhabdomyolysis with statins [65]Risk of myopathy, rhabdomyolysis and death from rhabdomyolysis with statins [65]. Figure 5 Risk of cardiac ... McMahon AD, Cleland JG, Davey PG, MacDonald TM: Cardiovascular prophylaxis with aspirin: costs of supply and management of upper gastrointestinal and renal toxic...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis" ppt
... analysis, and interpretation of data and partic- ipated in drafting the manuscript. NL participated in the analy- sis and interpretation of data. EB and FB -P contributed to the acquisition of ... re-evaluating all of the anti-CCP-positive patients. In our study, we decided to be very stringent in the application of ACR criteria, and we classify as RA those patien...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Improving therapeutic HPV peptide-based vaccine potency by enhancing CD4+ T help and dendritic cell activation" docx
... using HPV-16 E7 (aa 49-57) peptide with PADRE peptide or with poly(I:C) or with both poly(I:C) and PADRE peptide. Tumor-bearing mice treated with PBS or with poly(I:C) and PADRE without E7 peptide ... 49-57) peptide with 20 μg/mouse of PADRE peptide or with 20 μg/mouse of poly(I:C) or with both poly(I: C) and PADRE peptide. Tumor-bearing mice treated wi...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "A successfully thrombolysed acute inferior myocardial infarction due to type A aortic dissection with lethal consequences: the importance of early cardiac echocardiography" ppsx
... from angina pectoris. Other common presentations for type A dissections include syncope (13% of type A AADs) and abdominal pain (22% of type A AADs and 43% of type B AADs). The above symptoms have ... site of a ruptured atherosclerotic plaque [1]. Reperfusion therapies such as primary percutaneo us coronar y intervent ion (PPCI) and thrombolysis are mandatory steps for reducin...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Primary lower limb lymphedema: a focus on its functional, social and emotional impac"
... subtypes of primary lymphedema: congenital lymphedema, which is detected at birth or in the first year of life; lymphedema praecox which has its onset at the time of puberty [4]; and lymphe- dema ... 3% of patients with lymphe- dema received psychological support as a treatment approach [5]. It is also noteworthy that in a study among primary health care teams only 4 out...
Ngày tải lên: 25/10/2012, 11:40
Tài liệu Báo cáo Y học: Convulxin induces platelet shape change through myosin light chain kinase and Rho kinase ppt
... proteins, including PLCc2, but completely blocks the integrin aIIbb3-dependent dephosphorylation step: compari- sons with RGDS peptide, cytochalasin D, and phenylarsine oxide. Arch. Biochem. Biophys. ... inhibition of MLC phosphorylation, as demon- strated by the experiments with BAPTA, which only diminished MLC phosphorylation by about 50%. The enhanced capability of cAMP of inh...
Ngày tải lên: 21/02/2014, 01:21
Báo cáo Y học: A novel DNA repair enzyme containing RNA recognition, G-patch and specific splicing factor 45-like motifs in the protozoan parasite Toxoplasma gondii potx
... also found in a variety of RNA binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regu- lation of alternative splicing, and components of small nuclear ... status and perspectives. Cell Mol. Life Sci. 53, 621–645. 20. Aravind,L.&Koonin,E.V.(1999)G-patch,anewconserved domain in eukaryotic RNA-processing proteins and type...
Ngày tải lên: 08/03/2014, 22:20