Báo cáo y học: "Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study" ppt

... in identical twins. J Bone Joint Surg Br 1 959 , 41:314-318. 11. Mabuchi A, Nakamura S, Takatori Y, Ikegawa S: Familial osteoar- thritis of the hip joint associated with acetabular dysplasia maps to ... Nishida K, Furuichi T, Toki H, Nishimura G, Kawabata H, Yokoyama H, Yoshida A, Tominaga S, Nagano J, Shimizu A, Wakana S, Gondo Y, Noda T, Shiroishi T, Ikegawa S: A novel dom...

Ngày tải lên: 09/08/2014, 13:22

... milliliter of media was analyzed with the Human Inflamma- tion Antibody Array III (Raybiotech), which can detect 40 dif- ferent cytokines, or the Human Matrix Metalloproteinase Antibody Array (Raybiotech), ... enhancing chondrocyte catabolic activity [2]. In addition to inducing matrix degrading enzymes directly, these cytokines can also act by stimulating production of additional...

Ngày tải lên: 09/08/2014, 10:23

... investigation. With regards to the clinical implications of the presence of the PTPN22 1 858 T allele as a prognostic marker applicable in the clinical management in early stages of the disease, no ... prepared the manuscript. SK, SA, MW and CB participated in the collection of clinical data and the recruitment of patients into the study. UW and HH partic...

Ngày tải lên: 09/08/2014, 08:22

... Nat Genet 2007, 39 :52 9 -53 3. 6. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S: An aspartic ... Sudo A, Uchida A, Yamamoto S, Ozaki K, Takigawa M, Tanaka T, Nakamura Y, Jiang Q, Ikegawa S: A functional polymorphism in the 5& apos; UTR of GDF5 is associated with...

Ngày tải lên: 09/08/2014, 10:23

... significant association of the 1G- 5A haplotype with radiographic damage. The 1G- 5A haplotype explained the variability of the Ratingen score in the same order of magnitude as the SE. Our data suggest that ... score. It evaluates 38 joints separately (all proximal inter- phalangeal and metacarpophalangeal joints, four sites in the wrists, interphalangeal joints o...

Ngày tải lên: 09/08/2014, 01:23

... radiographs. The extent of OA development was evaluated for each of the 14 joints of each hand separately, in accordance with the grading system of Kellgren and Lawrence [19]. The OA evalu- ation was ... Russian Federation. The extent of osteoarthritis was determined by analyzing plain hand radiographs. The outcome of a principal component analysis of osteoarth...

Ngày tải lên: 09/08/2014, 06:23

... and their mean age at the start of the study was 39.6 years (standard deviation 11.3 years). The mean age at onset of psoriasis was 26.8 years (standard deviation 12.1 years) and the mean age at ... 14.2 years) and the mean age at onset of PsA was 38.1 years (standard deviation 11.0 years). Of the PsA patients, 60% had polyarticular disease, 32% had oligoarticular disease...

Ngày tải lên: 09/08/2014, 07:20

... non-White individuals included in the cohort was not included in the analysis. Of the available samples, genotyping was attempted in 1,600 and was successful in 1 ,58 9 in the current study. Of all the ... for all the assays, genotyping was confirmed in a subset of samples using the Pyrosequencing genotyping method according to manufac- turer's instructi...

Ngày tải lên: 09/08/2014, 08:22

... (Canary Islands, Spain). The median age at onset of RA was 45 years (interquartile range 27 to 63 years) and the median disease duration was 13 years (interquartile range 2 to 24); 74% of the ... the variation inherent in the assay, but it is likely that a significant amount of the scattering in the data is produced by interindi- vidual variations in several genes...

Ngày tải lên: 09/08/2014, 10:21

... deposition of genotypes and detailed phenotype data in public databases such as dbGaP [13] for use in (disease sub-type-specific) meta-analyses. ITGAV is the latest example of a candidate gene that may ... it may be another important step on the way to a better understanding of RA etiology and pathomechanisms, in particular the role of angiogenesis. Competing interests...

Ngày tải lên: 09/08/2014, 10:21