Báo cáo y học: "Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis" pot

... STA-5326 may be merely delaying the onset of EAU rather than decreasing the overall severity of inflamma- tion. However, STA-5326 also decreased inflammation when administered only during the effector ... EAU. Discussion In the present study, we showed that oral administration of the potent IL-12/IL-23 inhibitor, STA-5326, reduces the severity of EAU by clinical...

Ngày tải lên: 09/08/2014, 13:22

... suggest that the active components of the EA extract of TwHF inhibited the initiation of antibody responses but not ongoing antibody production by established plasma cells. Notably, treatment of RA ... selected NZB/W F1 mice to examine the potential therapeutic role of the EA extract of TwHF in SLE. The study was designed to start therapy of the NZB/W F1 mice at t...

Ngày tải lên: 09/08/2014, 07:20

... were anesthetized and spinal cord ischemia was induced by temporary occlusion of the descending thoracic aorta by a coronary artery balloon catheter, advanced through the femoral artery. The animals ... 2003:114. 10. Tsujino I, Miyagi K, Sampson R, Sieber F: Potentiation of the Anti- Tumor Effect of Merocyanine 540-Mediated Photodynamic Therapy by Amifostine and Ampotericin B...

Ngày tải lên: 10/08/2014, 10:20

... ster-linked. Information on the location of the a cetyl and glycyl groups as well as glycose sequence was provided by ESI tandem mass s pectrometry ( MS/MS ) in the positive ion mode following on- line separation ... served to confirm t he anomeric configurations of t he linkages a nd determine the sequence of the glycoses. Characterization of the Kdo-lipid A-OH element ....

Ngày tải lên: 31/03/2014, 21:21

... potentiate each other's synthesis, thereby creating an amplification loop for propagation of inflammatory responses [7]. Hence, inhibition of sPLA 2 may logically block the formation of ... moderately to severely damaged by the expansion of synovial pannus and destruction of cartilage and bone structures (Figure 6a). The beneficial effect of peptide treatment on s...

Ngày tải lên: 09/08/2014, 14:22

... and is one of the most common causes of disability in the Western world. The research network, EUROME (http://www.eurome.de/), supported by the EU Framework 5 Quality of Life and Management of Living ... inhibition was associated with reduced synovial vascular density. Finally, soluble VEGF receptor type I reduced synovial inflammation and bone destruction in CIA [6]. To study...

Ngày tải lên: 09/08/2014, 01:23

... differentiation and activation. To study the local expression of these factors we performed quantitative RT-PCR of the enzymes involved in the synthesis of these mediators (cyclooxygenase-2 (COX-2) ... the joints of CIA mice to the levels detected in non-arthritic control mice. This effect may be due to the inhibition of RANK synthesis or, alternatively, to the inhib...

Ngày tải lên: 09/08/2014, 06:23

... questions have not yet been addressed. The first question is whether the expression level for RIZ1 varies over the progression of cancer; and the second question is whether the PR domain alone ... activity. In this study, we quan- titatively analyzed the mRNA expression level of RIZ1 over the disease progression in eight different types of cancer, and evaluated the a...

Ngày tải lên: 25/10/2012, 11:15

... interventricular dyssynchrony Introduction The introduction of cardiac resynchronization therapy has recently renewed the clinical interest in the analysis of specific phases of the cardiac cycle and their ... cardiomyopathy (IDCM) diagnosed on the basis of the exclusion of other causes of LV dysfunction, such as of evidence of myocarditis in endomyocardial...

Ngày tải lên: 05/11/2012, 11:32

... hydrogen, modification of bonds, potentials of forcefield, and fixation of heavy atom, backbone, and Ca, were performed for molecular mechanics calculations. and then the energy minimization of the model ... at the same position as the high- affinity peak of wild-type LPL. The LPL in the eluate was detected by Western blot with LPL polyclonal antibody 7640. The fraction nu...

Ngày tải lên: 21/02/2014, 15:20