Báo cáo y học: " Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis" pot

... nevertheless support a regulatory role of RP105 in the development of arthritis induced by TLR ligands. On the other hand, these in vivo results cannot be explained by the in vitro data of splenic ... functional analysis of dendritic cells (DCs) and regulatory T cells (Tregs) from RP105- deficient miceThe functional analysis of dendritic cells (DCs) and regulatory T c...

Ngày tải lên: 09/08/2014, 13:22

... [44]. In the present study, we observed that activation of the cAMP pathway caused a significant change in the sumoylation machinery. The mRNA lev- els of the E1 activating subunit SAE1 and the SUMO specific ... (Fig. 7A). The mRNA levels of Cpy11a1 were 14-, 50- and 263-fold higher after 3, 12 and 24 h, respectively. To determine the effect of cAMP on sumoylation...

Ngày tải lên: 23/03/2014, 06:20

... N- and C-terminal parts of the ligand are cross-linked to domains I and III, respectively, of the receptor [19,22]. The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ... of the receptors was confirmed by immunoblotting of the cell lysates (Fig. 1B). As often observed for membrane proteins, the bands were rather broad in the...

Ngày tải lên: 24/03/2014, 03:21

... Interestingly, the repression of NR activity by histone H1 can be relieved by the ligand- dependent phosphorylation of H1 by cdk2 (and possibly other kinases, as well), which leads to the removal of H1 from ... thyroid hormone receptor and retinoic acid receptor, have the capacity to actively repress the transcription of their target genes in the absence of their c...

Ngày tải lên: 31/03/2014, 21:21

... many ways, relying upon the ITAMs of the associated Igα and Igβ chains, the B -cell- expressed SFKs Lyn, Fyn, and Blk, and the Syk kinase as well as homologous adaptors (Blnk/Slp-65 instead of ... common polymorphism associated with RA outside of the MHC [48,49]. Yet the functional consequences of many of these polymorphisms remain unclear. The subtlety of the...

Ngày tải lên: 09/08/2014, 01:22

... specific. Alternatively, the different abnormalities in the PSR- deficient mice may be related to the loss of a still unknown nonphagocytic function of the PSR. Further research will be required to test these hypotheses. Disposing ... process of cell suicide that leads to ordered destruction of the cells and their safe disposal by professional (macrophages and immatu...

Ngày tải lên: 09/08/2014, 01:23

... 1 A/G, and BtgI for exon 8 G/A polymorphism). There was no significant difference between primary knee OA patients and healthy control individuals in the distribution of any of the genotypes evaluated. ... = 53). The genotype distribution of the PvuII and XbaI polymor- phisms in the ER-α gene was reported to differ between racial and ethnic groups [13-15]. In the pre...

Ngày tải lên: 09/08/2014, 01:23

... according to the susceptibility of thymocytes to death and the capacity of the T -cell receptor (TCR) and downstream pathways to transmit an activation signal. Moreover, the efficiency of self-antigen presentation ... arthritis. They serve as APCs for T -cell priming, as accessory cells in the generation of primary antibody responses, and as producers of proinfla...

Ngày tải lên: 09/08/2014, 10:23

... difference. Results Chemokine receptor expression by B cells Chemokine receptor expression by naive CD27 - B cells and memory CD27 + B cells from the peripheral blood of healthy donors was analyzed by flow cytometry. ... CXCR3, CXCR4 or CXCR5, and the expression of the various markers was analyzed by flow cytometry. CD19 + B cells were gated, and the frequency of...

Ngày tải lên: 09/08/2014, 14:22

... entry [1,2], multiple studies suggested the presence of a secondary cellular receptor for HIV entry into the human CD4 cell [3,4]. These co- receptors, particularly the chemokine receptors CCR5 and ... syncytium inducing (SI) phenotypes on the MT2 cell line [12]. C-PSSM score for SJNAHS04 (known history of HIV positivity > 5 years) was -16.09 and SJNAHS13 (known histo...

Ngày tải lên: 10/08/2014, 05:21