Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx

... morphogenetic protein (BMP) ligands in synovium and cartilage during collagen-induced arthritisQuantitative polymerase chain reaction of different bone morphogenetic protein (BMP) ligands in synovium and ... are increasingly used to address the role of BMPs in disease pathogenesis. Our group previously studied the role of BMP signaling in joint homeostas...

Ngày tải lên: 09/08/2014, 13:22

... relative stability of A-form dsDNA in complex with the DNA polymerase is relatedtolessspecificdsDNA protein interactions. They include (a) relatively high hydrophobicity of the dsDNA binding cleft compared ... Ligation of RNA-containing duplexes by Vaccinia DNA ligase. Biochemistry 36, 9073–9079. 79. Sriskanda, V. & Shuman, S. (1998) Specificity and fidelity of strand joining by...

Ngày tải lên: 21/02/2014, 01:21

... fusion proteins containing th e GAL4 DNA- binding domain and the c-Ju n activation domain (residues 1–223) in wild-type and mutant forms ( not phosphorylat- able by mutation of both serines 63 and ... S., Nagano, Y. , Bloom, E.T. & Domae, N. (1998) Co-stimulation of T cells with CD2 augments T CR-CD3-mediated activation of protein tyrosine kinase p72syk, resulting in...

Ngày tải lên: 08/03/2014, 22:20

... determine the origin of the bone forming cells in our present case using immunohistochemical technique with S-100 protein as a marker of myoepithelial cells, and Runx2 as a marker of bone forming ... pathology. In addition, the bone tissue formed in the pleomorphic adenoma, revealed reversal line indicated by deeply-stained hematoxylin structure with osteoclasts...

Ngày tải lên: 08/08/2014, 16:23

... urine and corrected for urinary creatinine. Measurements of urinary NTx (nmol bone collagen equiva- lents/mmol creatinine) were performed by enzyme-linked immunosorbent assay (Osteomark NTx Urine; ... Heart Study Offspring cohort included surviving descendants (and spouses of descend- ants) of the original Framingham Heart Study cohort [25]. As part of a study of the inheritanc...

Ngày tải lên: 09/08/2014, 13:21

... matrix proteins, including vitronectin, osteopontin, and bone sialoprotein. Arg- Gly-Asp-containing peptides, Arg-Gly-Asp mimetics, and blocking antibodies to α v β 3 integrins inhibit bone resorption in ... measured by X-ray analysis. The RA joint synovial fluid and synovium contain a variety of hematopoeitic cells that are in direct proximity with the articular cartilage...

Ngày tải lên: 09/08/2014, 13:21

... clustered binding of chromatin orga- nizing proteins, patterns of histone modification and the tendency of regions to be physically close to one another in the nucleus [53-56]. The clustering of DDEs ... features of chromatin dynamics during embryogenesis, and identifying regulatory elements important for directing developmental processes remain key goals of devel opmental b...

Ngày tải lên: 09/08/2014, 22:24

... stringency, verifying this procedure. After washing at low stringency, approximately 17 bands (consistent with the number of hybridizing plaques/genome in the library screens) of various intensities ... tightly linked in this insect. However, v ery l arge arr ays of tandem genes a s f ound in ®sh type I and III AFPs [11,13], and hypothesized for Tenebrio AFP [ 14], are unlikel...

Ngày tải lên: 21/02/2014, 15:20

... analyzed by Western blotting. First we examined the binding of MCMs to the H3/H4 resin using an antibody against the conserved ATP binding domain of all MCM proteins [49]. This antibody cross- reacts ... (2001) Identi- fication of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cells. Biochem. J. 354, 655–661. 43. Zhang, J.J.,...

Ngày tải lên: 17/03/2014, 10:20

... (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein- dye binding. Anal. Biochem. 72, 248–254. 13. Goodwin, B., Jones, ... suggests the in uence of a strong inhibitory cis-acting element located between nucleotide )800 and nucleotide )512. Among known inhibitory consensus motifs, including AP-2, PuF, CRE...

Ngày tải lên: 17/03/2014, 23:20