Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf

... and pathogens. Among these are the C-type lectin receptors (CTLRs). The CTLRs comprise a family of evolutionarily conserved proteins contain- ing one or more C-type lectin domains, and may bind ... differentia- tion, increased baseline maturation, augmented synthesis of proinflammatory cytokines, and increased ability to promote increased proliferation and activation of...

Ngày tải lên: 09/08/2014, 13:22

... C, Zawatzky R, Kirchner H: Failure to detect antiviral activity in serum and plasma of healthy individuals displaying high activity in ELISA for IFN-α and IFN-β. J Inter- feron Cytokine Res 1999, ... important role in lupus- like complications of infliximab therapy as they do in lupus. We confirmed that infliximab acts on the regulation of IFNα system in vivo and in...

Ngày tải lên: 09/08/2014, 14:22

... [11]. However, anti-inflammatory cytokines and cytokine inhibi- tors are also present in large quantities in RA joints. IL-10, produced by macrophages and partly by T cells in the syn- ovial tissue ... Sunahori and Hirofumi Makino Department of Medicine and Clinical Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan Corresponding autho...

Ngày tải lên: 09/08/2014, 01:24

... X 1 is usually proline and X 2 can be any amino acid except for cysteine) reduces the binding score of most P1 anchored peptides from CII because glycine is an inhibitory residue at P4, P6, and P7, ... proline is inhibitory at P4 and P9. These constraints allow for few glycine–proline combinations that will permit interaction between peptide and the DR4 binding groove. The immunogen...

Ngày tải lên: 09/08/2014, 01:21

... test and/ or kerato- conjunctivitis sicca with involvement of salivary glands docu- mented by positive lip biopsy and/ or salivary scintigraphy). Simple x-rays of the hands and feet were analyzed ... histologically proved), non-compressive neuropathy confirmed by electromyography, or the diagnosis of Sjögren syndrome based on the clinical symptoms of dry eyes and dry mouth (conf...

Ngày tải lên: 09/08/2014, 10:20

... distinct C4A an d C4B isoforms [8]. The complement system is the main element of innate immu- nity and is regarded as the first line of defense against intrinsic and extrinsic antigens, leading ... SM, Lv YM, Shen M, Jiang HQ, Wang Y, Li K, Kang XJ, Liu YQ, Sun L, Liu ZF, Xie SQ, Zhu CY, Xu Q, Gao JP, Hu WL, Ni C, Pan TM, Yao S, He CF, Liu YS, Yu ZY, Yin XY, Zhang FY, Yang S, Zhou Y...

Ngày tải lên: 10/08/2014, 10:20

... from pituitary cells in vitro [7]. Since then, various biological activities of TS such as inhibition of acetylcholine esterase activity [8] and induction of apoptosis in various cancer cells have ... S L., Lin, P L. & Lin, C N. (1999) Stimulation of respiratory burst by cyclocommunin in rat neutrophils is associated with the increase in cellular Ca 2+ and protein...

Ngày tải lên: 22/02/2014, 04:20

... existense of three dinstict domains, namely: the highly conserved J domain consisting of approximately 70 amino acids a nd known to mediate the hsp70 binding; the glycin e/phenylalanine (G/F) rich ... boiled for 5 min and analyzed by 10% SDS-mini PAGE and Western blotting. Indirect immunofluorence CV1 cells growing in coverslips were incubated at 37 °Cor 43 °C for 2 h as indicated...

Ngày tải lên: 17/03/2014, 17:20

... binding to the protein surface can evidently not be compensated by the gain of enthalpy on binding, so that the scoring function of the docking program used indicated no or only weak binding. ... C-terminal cysteines and folding of the molecule into the starting conformation was per- formed using the Conformational Analysis Tools (CAT) [31] software applying the method briefly ou...

Ngày tải lên: 08/08/2014, 17:20

... tissues. Mast-cell biology has assumed increasing prominence in theories of synovitis, providing a potential cellular link between humoral autoimmunity (B cells) and synovial inflammation [10]. The present ... tissues during the early phase of innate inflammatory responses. Mast-cell presence and activation in synovium has been long described within inflammatory aggregates and...

Ngày tải lên: 09/08/2014, 01:23