Báo cáo y học: "Vascular involvement in rheumatic diseases: ‘vascular rheumatology" pps

... the understanding of MetS. The insulin receptor has an intrinsic tyrosine kinase activity. Binding of insulin to its receptor induces both autophosphorylation and phosphorylation of tyrosine residues on insulin ... [8]. Pathophysiology: complementary roles of insulin resistance and abdominal obesity Insulin signaling Since insulin resistance is a key feature of this syndrome, a brief overview...

Ngày tải lên: 09/08/2014, 10:23

... similarly to the RA joint, are characterized by enhanced accumulation of inflammatory monocytes/ macrophages and T cells. These inflammatory leukocytes abundantly produce proinflammatory cytokines, ... Ligands Selectins L-selectin (CD62L, LAM-1) Sialylated carbohydrates, GlyCAM-1 E-selectin (CD62E, ELAM-1) Sialyl-Lewis-X P-selectin (CD62P, PADGEM) Sialyl-Lewis-X, other carbohydrates Integrins...

Ngày tải lên: 09/08/2014, 13:22

... skewing of aberrant T cells). SCID with maternal fetal engraftment is diagnosed by identifying lymphocytes of maternal origin, by XX/XY karyotyping if the patient is male or by tissue typing ... abnormal in early childhood resulting in recurrent respiratory tract infections. There is also an increased incidence of auto- immunity including cytopenias, arthritis and endo- crinopathy in up...

Ngày tải lên: 08/08/2014, 21:20

... Rolph MS: Over- lapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines inter- leukin-1 beta and tumor necrosis factor. Inflamm Res 2005, 54:10-16. 27. ... healthy control individuals (n = 21). They identified 81 differentially expressed genes, including those encoding glutaminyl cyclase, IL-1 receptor antagonist, S100A12 and Grb2...

Ngày tải lên: 09/08/2014, 01:22

... Centre in Hinxton, UK in July 2009, to jointly address these issues by bringing together for the first time key representatives of the major methods and databases in the field of orthology prediction. The ... with additional information (protein-protein interaction and synteny data, respectively) might improve predictions. In contrast, most algorithmic Correspondence Joining for...

Ngày tải lên: 09/08/2014, 20:20

... rethinking the biology and intervention strategies. Nat Rev Microbiol 2009, 7:845-855. 5. Lin PL, Pawar S, Myers A, Pegu A, Fuhrman C, Reinhart TA, Capuano SV, Klein E, Flynn JL: Early events in ... latent infections are not binary but, instead, represent different ends of a continuum of disease [4]. is new paradigm of TB is largely based on studies in nonhuman primates, including t...

Ngày tải lên: 09/08/2014, 22:23

... [55]. Cell sources for tissue engineering in rheumatic diseases Today, autologous chondrocytes represent the only cell type routinely used for joint cartilage repair. In the future, autolo- gous or ... purpose, 3D in vitro high-density chondrocyte pellet and alginate cultures help to preserve/regain the chondrocyte phenotype following monolayer expansion by offering cell-cell and cell...

Ngày tải lên: 09/08/2014, 01:22

... and synovial cell hyperplasia. The induction of proinflammatory cytokines produced primarily in the synovium, but also by chondrocytes, results in the upregulation of cartilage-degrading enzymes ... surrounding joint tissues. In RA, the inflamed synovium is the major source of cytokine-induced proteinases, although the episodic intra-articular inflammation with synovitis indicates that...

Ngày tải lên: 09/08/2014, 01:22

... to target key cytokines implicated in JIA, including TNFα, IL-1, IL-6 as well as signaling molecules involved in the regulation of B-cell and T-cell lymphocyte responses (Table 4). Although promising ... Wallace CA, Chon Y, Lin SL, Baum- gartner SW, Giannini EH, Pediatric Rheumatology Collaborative Study Group: Safety and efficacy of up to eight years of con- tinuous etanercept therapy...

Ngày tải lên: 09/08/2014, 01:22

... articular Figure 6 Glycosaminoglycan (GAG) remaining in the cartilage extract treated with reactive oxygen species (ROS) or antioxidative agent in tissue cultureGlycosaminoglycan (GAG) remaining in the cartilage ... stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ageing and the development of OA through a mechanism involving t...

Ngày tải lên: 09/08/2014, 06:22