Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... disease activity, and the suppressive function ofthese cells was intact in cultures without antigen-presenting cells. The functional activity of both patient and healthycontrol Tregs, however, ... frombecoming Th17 proinflammatory effector cells. Depletion ofReviewRegulatory T cells in systemic lupus erythematosus: past, present and futureDavid A HorwitzDivision of Rheumatology and Immunology, ... function. In active lupus, the products of the apoptotic cells that bind toToll-like receptor 7, Toll-like receptor 8, and Toll-like receptor9 [84] expressed by DCs, and the proinflammatory cytokinesproduced...
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Báo cáo y học: "Targeting B cells in systemic lupus erythematosus: not just déjà vu all over again" pdf
... toxicities have emerged. One trivial possibility is thatthe binding of CD22 changes little in the organism, and thusthe current randomized controlled trial may fail to findevidence for therapeutic ... even the fall in B cells in peripheral blood is quite modest and inconsistent (Figure 5 in [1]), there is at present no obvious way to follow patientsfor physiological effects of the treatment ... immunotherapy of systemic lupus erythematosus. Arthritis Res Ther 2006, 8:R74.2. Tedder TF, Poe JC, Haas KM: CD22: a multifunctional receptorthat regulates B lymphocyte survival and signal transduction.Adv...
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Báo cáo y học: "egulatory T cells in rheumatoid arthritis" ppsx
... healthy individuals, where theyretain their capacity to initiate autoimmune inflammation [2],negative selection in the thymus is not sufficient to preventthe activation of self-reactive T cells ... occurred in theculture of PBMC derived from anti-TNF-treated patients withRA that were depleted of Tregs [38]. Together, these datamight underline the potential role of cytokines in maintainingchronic ... envisaged in which Tregs generated and/ or expanded in vitro will beemployed in an attempt to control local and systemic autoimmune inflammation.Competing interestsThe author(s) declare that they have...
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Báo cáo y học: "Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal" ppsx
... anti-dsDNA antibodies are pathophysio-logically involved in other clinical manifestations. Recentfindings that intrathecal binding of anti-dsDNA antibodiesto the NR2 glutamate receptor induces ... clinicallyrelevant antibodies occurs. If anti-DNA antibodypathogenicity is determined by the interaction betweenantibody and tissue-specific antigens, the selectionprinciple and/ or the organ-specific binding ... classification, and this relatively simplealteration might significantly alter the face of SLE as weknow it today.The broad definition of ‘antibody to native DNA in anabnormal titer’ [4] reflects technical...
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Báo cáo y học: "Replication of recently identified systemic lupus erythematosus genetic associations: a case–control study" pps
... significance.Tyk2 is a Janus-family tyrosine kinase that is bound to cytokinereceptors and becomes activated after ligand binding. Defi-ciency of TYK2 leads to defects of multiple cytokine pathways,including ... effect in women and men.Competing interestsThe authors declare that they have no competing interests.Authors' contributionsMS-G participated in design of the study, in genotyping thesamples, ... associa-tion with another TYK2 SNP (rs12720270) that was not asso-ciated in the Scandinavian study. Finally, the InternationalConsortium for Systemic Lupus Erythematosus Genetics(SLEGEN) GWA study...
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Báo cáo y học: "TH-17 cells in rheumatoid arthritis" pdf
... ±7.5 years), of whom there were three taking methotrexatealone, two taking methotrexate plus an anti-TNF, one takingmethotrexate and leflunomide, two taking methotrexate and abatacept and one ... between that study and other studies concerning IL-17 and TH-17 cells (includingthe work presented here) is not clear, although it is possiblethat differences in patient selection and therapy ... that they have no competing interests.Authors' contributionsSS was responsible for the design of the study, acquisition ofdata, analysis and interpretation of the data, and manuscriptpreparation....
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Báo cáo y học: "Mesenchymal stem cells in arthritic disease" pot
... proliferative ability in anuncommitted state while retaining the potential todifferentiate along various lineages of mesenchymal origin,including chondrocyte, osteoblast, and adipocyte lineages, in response ... immunosuppressive and anti-inflammatory functions that have been demonstratedboth in vitro and in vivo. Due to the scarcity of MSCs,especially the apparent decrease in quantity and quality withage and diseases, ... macrophages, and FLSs to produce inflammatory mediators, including IL-1,TNF-α, IFN-γ, and IL-6, and secrete MMPs, leading to the systemic inflammation that eventually results in jointdestruction [78,80]....
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Báo cáo y học: "Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depressionLine bisection performance in patients with generalized anxiety disorder and treatment-resistant depression"
... on the other. Bearing that GAD and TRD patients often present negative emotions in mind, we have hy-pothesized that these subjects would bisect lines fur-ther leftward than the healthy volunteers ... bisection error to the left of the true center has been interpreted as a relative right hemisphere activation, which might relate to the subject’s emotional state. Considering that patients with ... negatively correlated with Disinhibition-Seeking in the healthy subjects, and with Total sensation-seeking and Experience-Seeking in GAD patients, while the Magnitude of the line bisection...
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Báo cáo y học: "Skin prick testing in patients using beta-blockers: a retrospective analysis" pot
... patient was takingcetirizine and another was taking amitriptyline at thetime of skin testing. These medications may haveblunted the skin test response. Other common concomi-tant medications ... important, we argue that withallergy skin prick testing and intradermal testing withinsect venoms and penicillin, the risk of anaphylaxis isso low that testing can be completed safely on mostpatients ... available in the clinics where skin testing isbeing performed.This study provides information regarding the safetyof skin prick testing in patients taking beta-blockermedications. To date, this...
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Báo cáo y học: "Estimated intelligence quotient in anorexia nervosa: a systematic review and meta-analysis of the literature" pot
... population. We based this hypothesis onthefactthatitwasshownthatIQpredictsterminationfrom treatment; that is, patients with a higher IQ aremore likely to remain in psychological treatment [14].MethodsSearch ... contributed to drafting the manuscript. DS contributed to thedesign of the study, performed the statistical analyses, drafted the resultssection and critically reviewed the manuscript. KT contributed ... factors that might be related to optimalintellectual level [8].The intelligence quotient (IQ) represents a compositescoreonavarietyoftestsdesignedtomeasureahypothesised general ability or intelligence...
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Từ khóa: Nghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ