Báo cáo y học: "Developments in the scientific and clinical understanding of gout" docx

... prosperity and increased life expectancy and age of the population. Uric acid metabolism Uric acid is the end result of the purine metabolic pathway and the product of the conversion of xanthine, by the ... http://arthritis-research.com/content/10/5/221 Abstract Gout is the most common form of inflammatory arthritis in the elderly. In the last two decades...

Ngày tải lên: 09/08/2014, 13:22

... the definition of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [21], the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Metrology ... and scientific understanding of the spondyloarthritides (SpA), which can be separated in predominantly axial and predominantly peripheral SpA. The clinical progress incl...

Ngày tải lên: 09/08/2014, 01:22

... proteins of apparently disparate function and cellular localisation. Pyrin is thought to interact with a variety of proteins within the cytoplasm and to play a key role in the modulation of inflammation ... characterised by fluctuating or irregularly recurring episodes of fever and systemic inflam- mation, affecting the skin, eyes, joints, and serosal surfaces. They in...

Ngày tải lên: 09/08/2014, 01:22

... identifying novel molecular pathways that could be relevant for future therapies. Review Developments in the scientific and clinical understanding of inflammatory myopathies Ingrid E Lundberg and ... pro- inflammatory cytokine transcript profiles and protein expression pattern between inclusion body myositis and polymyositis patients, on one hand, and dermatomyositis pat...

Ngày tải lên: 09/08/2014, 13:21

... serotonin and noradrenalin reuptake inhibitors (duloxetine and milnacipran). As our understanding of the biological basis in general – and the genetic underpinning, in particular – of FM increases, ... Research performed in recent years has demonstrated a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the...

Ngày tải lên: 09/08/2014, 14:21

... occur after an initial phase of activity; in other patients the disease is more sustained. The challenge in understanding SLE is therefore to explain the heterogeneity in disease course and to develop ... disease in mice of several strain backgrounds. These studies indicated clearly Review Developments in the scientific understanding of lupus Stacy P Ardoin 1...

Ngày tải lên: 09/08/2014, 11:20

... even in early OA [67]. Synovial histologic changes include synovial hypertrophy and hyperplasia, with an increased number of lining cells, often accompanied by infiltration of the sublining tissue ... or inhibitors of inflammatory cytokines. Degeneration of articular cartilage in osteoarthritis: inflammation The role played by inflammatory cytokines and mediators produced...

Ngày tải lên: 09/08/2014, 14:20

... concentration of β-catenin in the cytoplasm of the cell. The binding of Wnt proteins act on the target cell by binding to frizzled receptors and their co-receptor LRP5/6 that stabilizes cytoplasmic ... produc- tion of osteoprotegerin (OPG) by mature osteoblasts. New studies that may expand our understanding of the Wnt signaling pathway and bone formation The disc...

Ngày tải lên: 09/08/2014, 14:20

... knowledge of the pivotal role played by cytokines during the effector stages of human disease; has been instrumental in clarifying the place of cytokines in the maintenance and chronicity of inflamma- tion; ... citrullination may play a role in the initiation of an immune response. The finding that Asian RA patients are more likely to have inherited an enzyme var...

Ngày tải lên: 09/08/2014, 14:22

... the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which the lead investigator became the study subject ... provided new insights into how OA may be successfully managed. The symptoms of osteoarthritis: pain and instability The pain of OA is activity...

Ngày tải lên: 09/08/2014, 01:22