Báo cáo y học: "Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis" ppsx

... article Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis Bence György 1 , László Tóthfalusi 2 , György Nagy 1,3 , Mária Pásztói 1 , Pál Géher 3 , Zsolt Lörinc 4 , Anna ... antibody binding was inhibited by an anionic exchanger resin, we hypothesise that weak ionic interactions might play a pivotal role in the recognition of polyanionic GAGs by the...

Ngày tải lên: 09/08/2014, 13:22

... played by B cells as antigen-presenting cells in rheumatoid arthritis B cells actively participate in an autoimmune process through interaction with T cells by a variety of mechanisms, including antigen ... the lymphoid-like structures and to a reduction in T-helper (Th)1 interferon-γ producing cells, which are known to be involved in the induction and maintenance of the proinflam...

Ngày tải lên: 09/08/2014, 10:20

... antigen presentation in monocytes and inhibits the production of pro- inflammatory cytokines, GM-CSF, and Fc-γ receptors by synovial Mφ. Consistently with cytokine and chemokine downregulation, IL-10 clearly suppresses ... TNF-R75 in the rheumatoid synovial membrane: TNF receptors are localized preferentially in the lining layer; TNF-alpha is distributed mainly in the vicinity of...

Ngày tải lên: 09/08/2014, 10:22

... clinical response, suggesting that their RA was not much driven by TNF-α activity alone but probably by other cytokines or mechanisms. The heterogeneity in these patterns may be explained by higher ... functional assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate synoviocytes, RA synovial tissues were fin...

Ngày tải lên: 09/08/2014, 06:22

... antibody-dependent cellular cytotoxicity [6]. Con- versely, FcγRIIb contains an inhibitory motif in the cytoplasmic tail and abrogates cellular activation. FcγRIIb may also play a role in maintaining ... haplotype suggests that other polymorphic variants within FCGR3A or FCGR3B, or in linkage disequilibrium with this haplotype, may additionally contribute to disease pathogenesis. Intr...

Ngày tải lên: 09/08/2014, 07:20

... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE = hematoxylin and eosin; ... induced during growth inhibition in murine cell lines [33]. Recently, Taniguchi et al. [34] showed that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF by several growth-inhi...

Ngày tải lên: 09/08/2014, 06:22

... formation induced by RANKL was completely inhibited by adding OPG, but osteoclastogenesis induced by TNF-α was not. Adding antibodies against TNFR1 and TNFR2 blocked osteoclast formation induced by TNF-α ... [28,29] examined the contribu- tion of soluble factors in the interaction between T cells and synoviocytes in RA patients. IL-17 induced production of IL-6 and leukemia inhibitory fac...

Ngày tải lên: 09/08/2014, 06:22

... concept’ of interacting activities contributing in synergy across distinct tissue events. In particular, cytokine mediated pathology may be distinct in cartilage and bone as opposed to synovial tissue ... function in varied tissue cell lineages including keratinocytes, osteoclasts and chondrocytes [2]. Importantly, IL-18 often acts in synergy rather than independently, and for some...

Ngày tải lên: 09/08/2014, 06:22

... frequent [1], indi- cating a considerable influence of other pro-inflammatory cytokines beside TNF in perpetuating inflammation in RA. IL-15 has been identified as a pro-inflammatory cytokine of potential ... present in synovial tissue in rheumatoid arthritis before and after treatment with infliximab. Sections of synovial biopsy tissue from patient no. 5 show diaminobenzidine st...

Ngày tải lên: 09/08/2014, 07:20

... bone turnover within the joints of interleukin-1 receptor antagonist deficient mice [31]. In a single patient with early RA, increased uptake in a central, interarticular distribution was detected by MPH-SPECT ... Magnetic resonance imaging examinations of the spine in patients with ankylosing spondylitis, before and after successful therapy with inflix- imab: Evaluation of a new...

Ngày tải lên: 09/08/2014, 08:23