Báo cáo y học: "Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis" ppsx

... articleNatural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritisBence György1, László Tóthfalusi2, György Nagy1,3, Mária Pásztói1, Pál Géher3, Zsolt Lörinc4, Anna ... antibody binding was inhibited by an anionicexchanger resin, we hypothesise that weak ionic interactionsmight play a pivotal role in the recognition of polyanionicGAGs by these immunoglobulins. In ... autoantibodies in patients with rheumatoid arthritis. This study examined systematic antibodies reactive to glycosaminoglycans (GAGs), the carbohydrate components ofproteoglycans that are released in large...

Báo cáo y học: " Review Cells of the synovium in rheumatoid arthritis" ppsx

... played by B cells as antigen-presentingcells in rheumatoid arthritisB cells actively participate in an autoimmune process throughinteraction with T cells by a variety of mechanisms, includingantigen ... the lymphoid-like structures and to a reduction in T-helper (Th)1 interferon-γ producing cells, which areknown to be involved in the induction and maintenance of theproinflammatory cytokine ... played by B cells in the maintenance of ectopicgerminal centre-like structures, as well as in the immuneresponse in RA synovium, has been addressed by using ahumanized experimental model in...

Báo cáo y học: "Review Cells of the synovium in rheumatoid arthritis" ppsx

... antigenpresentation in monocytes and inhibits the production of pro-inflammatory cytokines, GM-CSF, and Fc-γ receptors bysynovial Mφ. Consistently with cytokine and chemokinedownregulation, IL-10 clearly suppresses ... TNF-R75 in the rheumatoid synovial membrane: TNF receptors are localizedpreferentially in the lining layer; TNF-alpha is distributedmainly in the vicinity of TNF receptors in the deeper layers.Scand ... of a fully humanized anti-IL-15antibody in clinical trials [56-58].Interleukin-18 In the RA synovial membrane, this cytokine of the IL-1 familyis expressed in CD68+Mφ contained in lymphoid...

Báo cáo y học: "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical respone" pot

... clinical response, suggesting that their RAwas not much driven by TNF-α activity alone but probablyby other cytokines or mechanisms.The heterogeneity in these patterns may be explained byhigher ... functional assay for TNF-α activity was designed usingthe ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate synoviocytes, RA synovialtissues were finely minced ... bycytokines in mediating cell–cell interactions in rheumatoid synovium has led to the rational development of treatment with anticytokine agents. Among these proinflammatorycytokines, tumour...

Báo cáo y học: "Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B" ppsx

... antibody-dependent cellular cytotoxicity [6]. Con-versely, FcγRIIb contains an inhibitory motif in the cytoplasmictail and abrogates cellular activation. FcγRIIb may also play arole in maintaining ... haplotype suggests that otherpolymorphic variants within FCGR3A or FCGR3B, or in linkagedisequilibrium with this haplotype, may additionally contribute todisease pathogenesis.Introduction Rheumatoid ... 2000,50:133-139.33. Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, EhmMG: Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelatedindividuals....

Báo cáo y học: "Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation" potx

... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con-verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE = hematoxylin and eosin; ... induced during growth inhibition in murine cell lines [33]. Recently, Taniguchi et al. [34]showed that cyclin-dependent kinase inhibitor p16INK4aisinduced in RA-SF by several growth-inhibited ... ribonucleoprotein polypeptide B“TomoregulinCDC10CD26Glucocorticoid receptorDyneinUbiquitin conjugating enzyme E2AStaufenEpithelial protein lost in neoplasm (EPLIN)RNASE 4IntroductionRecently,...

Báo cáo y học: "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis" pptx

... formationinduced by RANKL was completely inhibited by addingOPG, but osteoclastogenesis induced by TNF-α was not.Adding antibodies against TNFR1 and TNFR2 blockedosteoclast formation induced by TNF-α ... [28,29] examined the contribu-tion of soluble factors in the interaction between T cellsand synoviocytes in RA patients. IL-17 induced productionof IL-6 and leukemia inhibitory factor in synovial ... anti-inflammatory cytokines IL-4 and IL-13completely inhibited the production of IL-17 in synovialtissues [30]. Lubberts et al. [31] recently reported the IL-4gene therapy for collagen-induced...

Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx

... concept’ of interactingactivities contributing in synergy across distinct tissueevents. In particular, cytokine mediated pathology may bedistinct in cartilage and bone as opposed to synovialtissue ... function in varied tissue cell lineages including keratinocytes,osteoclasts and chondrocytes [2]. Importantly, IL-18 oftenacts in synergy rather than independently, and for someactivities it remains ... mediated in part via P2X7dependent pathways. In the extra cellular domain IL-18 isantagonised by IL-18 binding protein and in part bysoluble IL-18Rα, although lower affinity binding of thelatter...

Báo cáo y học: "Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor" docx

... frequent [1], indi-cating a considerable influence of other pro-inflammatorycytokines beside TNF in perpetuating inflammation in RA.IL-15 has been identified as a pro-inflammatory cytokine ofpotential ... present in synovial tissue in rheumatoid arthritis before and after treatment with infliximab. Sections of synovial biopsy tissue from patient no. 5 show diaminobenzidine staining (haematoxylin counterstained) ... abundant bindingto extracellular material adjacent to cells that are intracellularlystained with this antibody. In addition, more cells are stained with 2C8 than with mAb1 and mAb11, indicating that...

Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte" ppt

... boneturnover within the joints of interleukin-1 receptor antagonistdeficient mice [31]. In a single patient with early RA,increased uptake in a central, interarticular distribution wasdetected by MPH-SPECT ... Magnetic resonanceimaging examinations of the spine in patients with ankylosingspondylitis, before and after successful therapy with inflix-imab: Evaluation of a new scoring system. Arthritis Rheum2003, ... heads within only two months of the onset ofsymptoms. Tamai and colleagues [21] recently confirmed itsassociation with disease severity as indicated by inflammatorymarkers such as C-reactive...

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