Báo cáo y học: "Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus" potx

... study of belimumab in SLE patients with stable, mild to moderate disease activity and demonstrated its safety, biologic activity, and pharmacokinetics. Materials and methods Patients Patients aged ... work is properly cited. Abstract Introduction This trial evaluated the safety, biologic activity, and pharmacokinetics of belimumab, a fully human monoclonal an...

Ngày tải lên: 09/08/2014, 13:21

... Ficarelli R, Maltese P, Bisonni R, Masi G, Schiavon G, Giordani P, Giustini L, Falcone A, Tonini G, Silva R, Mattioli R, Floriani I, Magnani M. Pharmacogenetic profiling in patients with advanced ... Canestrari E, Ficarelli R, Menichetti ET, Mari D, Testa E, Silva R, Vincenzi B, Giordani P, Cascinu S, Giustini L, To- nini G, Magnani M. Pharmacogenetic profiling and clinical outc...

Ngày tải lên: 25/10/2012, 10:51

... rural children in mainland China. Optom Vis Sci. 2009; 86: 40-44. 18. National Bureau of Statistics of China. China statistical year- book 2003 [in Chinese]. Beijing: China Statistics Press. 2003: ... - paring astigmatism prevalence between academically challenging and regular schools, we discovered that the prevalence rates of myopic astigmatism and hyperopic astigmatism...

Ngày tải lên: 25/10/2012, 11:40

... cellular and in vivo animal models, Aflapin showed significantly better efficacy in comparison with 5-Loxin ® . In addition, Aflapin exhibited better AKBA bioavailability than 5-Loxin ® in Wistar ... remained within the normal laboratory range. Statistical ana- lyses of these parameters did not indicate any signif- icant changes. Similarly, no significant changes in hemat...

Ngày tải lên: 25/10/2012, 11:40

... serine/threonine and tyrosine phosphorylation. In an attempt to rectify this by probing porcine liver cytosol with the phosphohistidine- containing peptide succinyl-Ala-His(P)-Pro-Phe-p-nitro- anilide ... start signal: a review of the pathway in Escherichia coli. Biochimie 75, 1061–1075. 29. Matthews, H.R. & MacKintosh, C. (1995) Protein histidine phosphatase activity in r...

Ngày tải lên: 21/02/2014, 01:21

... Brassicaceae, whereas Solanaceae, including potato, tomato and tobacco, Fabaceae, including soybean and peanut, and Poaceae, including barley and rice, have additional groups and subgroups of ... (1979) Purification of the o-diani- sidine peroxidase from Escherichia coli B. Physicochemical char- acterization and analysis of its dual catalatic and peroxidatic activities. J....

Ngày tải lên: 21/02/2014, 01:21

... explain the variations in enzymatic activity. One possibility therefore is that EDTA could chelate inhibitory ions, whose identity remains unclear, maybe with a higher affinity than for Mn 2+ . If ... 2351 Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis Anne-Marie Justin, Jean-Claude Kader...

Ngày tải lên: 22/02/2014, 04:20

... deoxyoligonucleotide (5¢-CGC GGATCCATGTATAAGACAATCATTATGC-3¢) containing a BamHI site (underlined nucleotides) and a 3¢ deoxyoligonucleotide harboring a HindIII site (5¢-CCC AA GCTTTTAACGCACAACCAGCACC-3¢) ... A, containing 0.01% DM, using protein A Sepharose pre- loaded with affinity-purified anti-GroEL Ig. Blocking of unspecific binding sites was accomplished by incubation with...

Ngày tải lên: 22/02/2014, 07:20

... Chemistry, National Taiwan University, Taipei, Taiwan; 2 Graduate Institute of Biochemistry, Yang-Ming University, Taipei, Taiwan An N-acyl- D -amino acid amidohydrolase (N-D-AAase) was identified in cell ... identity and 63.6% similarity), N-acyl- D -glutamate amidohydrolase (44.8% identity and 51.2% similarity) and N-acyl- D -asparate amidohydrolase (48.5% identity and 56.5% simi...

Ngày tải lên: 08/03/2014, 16:20

... Asn219 have been implicated in the stabilization of the carboca- tion intermediate [43]. In UPPS, there are several conserved hydrophilic amino acids in the vicinity of Asp26, including Asn28, Arg30, ... reflecting their pep- tide substrate specificity. Reaction mechanism and kinetics of protein: prenyltransferase Kinetic analysis of the enzymatic prenylation reaction reveals a...

Ngày tải lên: 08/03/2014, 22:20