Báo cáo y học: "An important step towards completing the rheumatoid arthritis cycle" pptx

... intimately involved in the pathophysiology of rheumatoid arthritis and complete our model (the rheumatoid arthritis cycle) for the development and chronic nature of this disease. Rheumatoid arthritis ... synovial proteins like fibrin(ogen). Editorial An important step towards completing the rheumatoid arthritis cycle Walther J van Venrooij and Ger JM Pruijn Depa...

Ngày tải lên: 09/08/2014, 13:21

... days 50-70 days good not for tissue continuously stressed MONOCRYL: glycolide and epsilopn caprolacton copolymer monofilament 50% at 14 days 105 days good Obstetrics- gynecology, urology, ... and the velocity was 50mm/sec. The test ends at the break point. The breakage strength was measured by the dynamometric cell (sensibility 0.01 N), while the elongation was cal- culated...

Ngày tải lên: 03/11/2012, 11:52

... delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human interverte- bral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther 2007, 9:R83. 19. ... 2b). Table 1 Details of the immunohistochemistry methodology employed Target Antigen retrieval Blocking step and primary antibody Secondary antibody Aggrecan 0.1% w/v hyaluronidas...

Ngày tải lên: 09/08/2014, 01:22

... expression or affinity of these IgG receptors or that enhance their ability to bind spe- cific IgG isotypes may therefore play an important role in deter- mining the severity and persistence of ... indicate that they may not develop in the future. The control population was therefore felt to be the most appropriate reference group for analysis of the subgroup with nodular RA [31]....

Ngày tải lên: 09/08/2014, 07:20

... smoking and rheumatoid arthritis. The role of menopause in the etiology of rheumatoid arthritis merits further research. Keywords: etiology, interaction, risk, rheumatoid arthritis, sex, smoking Open ... quantitate the risk of smoking on RF-positive and RF-negative RA separately. The potential limitations of the study also must be addressed. By design, the study was an u...

Ngày tải lên: 09/08/2014, 01:21

... performed surgically, chemically or by radiation therapy, immediately stops the arthritic process and delays recurrence of disease in that joint for many years [8]. With gene therapy it may be possible ... cell death in the synovium and cytolysis of the synovial lining layer in both arthritis models. An alternative approach for suicide gene therapy is to inhibit cell proliferation. T...

Ngày tải lên: 09/08/2014, 01:24

... identify genes that characterize the pheno- type of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum 1998, 41:1356-1364. 17. Zanders ED, Goulden MG, Kennedy TC, Kempsell KE: Analysis of ... days, the cells at low density (LD) proliferated exponentially, and at 14 days, the cells at high density (HD) almost ceased to proliferate as a result of contact inhibition. The i...

Ngày tải lên: 09/08/2014, 06:22

... only these two cytokines was modulated by protein I/II. IL-6 and leukemia inhibitory factor, which both belong to the same family of cytokines, are known to participate sub- stantively in the ... in the syno- vial tissue of patients with advanced rheumatoid arthritis or osteoarthritis: analysis with gas chromatography-mass spec- trometry and pan-bacterial polymerase chain reaction....

Ngày tải lên: 09/08/2014, 06:22

... suggesting that their RA was not much driven by TNF-α activity alone but probably by other cytokines or mechanisms. The heterogeneity in these patterns may be explained by higher disease activity for responders ... p75) measured by ELISA. This discrepancy further indicates the usefulness of a bioassay when function is the key. Such complexity has been observed when trying to explain los...

Ngày tải lên: 09/08/2014, 06:22

... Although synovial IL-18 expression has been considered the primary target, expression elsewhere in the circulation and in the lymphoid system may also be therapeutically important – we recently reported ... including keratinocytes, osteoclasts and chondrocytes [2]. Importantly, IL-18 often acts in synergy rather than independently, and for some activities it remains unclear whether di...

Ngày tải lên: 09/08/2014, 06:22