Báo cáo y học: "4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase" doc

... energy substrate for articular chondro- cytes and as the main precursor for the synthesis of ECM gly- cosaminoglycans in cartilage [35,36]. The inhibition of proteoglycan synthesis in OA chondrocytes ... cell types due to changes in the availa- bility or sensitivity of specific regulatory pathways that are acti- vated by the aldehyde. Investigation of the molecular m...

Ngày tải lên: 09/08/2014, 13:21

... system (PNS)). Indeed the patient could have different feelings toward the same therapy depending on the purpose it is given for and depending on the specialty of the prescribing doctor. The individual ... about their constipation. He received a courtesy title of 'purgative doctor', obtaining the wedding ring of the Princess of Argos and receiving part part...

Ngày tải lên: 08/08/2014, 23:21

... successful development in the future. Gene therapy The current use of gene therapy in the treatment of OA is a result of success in identifying major pathophysiological pathways of the disease process. The principle ... proteoglycan degradation in chondrocytes, and IL-1-induced microsomal PGE synthase-1 in synoviocytes [73-77]; the latter enzyme is the last key...

Ngày tải lên: 09/08/2014, 07:20

... study, performed the majority of the laboratory work and analysis, and drafted the manuscript. AJF participated in the design of the study and interpretation of data. JAH conceived the study, ... marker of rep- licative history and of the cumulative history of stress inducers of senescence, as well as an indicator of the probability of cell senescence [25]....

Ngày tải lên: 09/08/2014, 10:20

Ngày tải lên: 09/08/2014, 13:22

... func- tion of each of these enzymes, although they are presumed to be active predominantly intracellularly [26,27]. Cathepsin H, cathepsin C, cathepsin F, cathepsin W, cathepsin B and cathepsin S are ... proteomics study confirms that cathepsin D is highly expressed in chondrocytes [25], its role in cartilage degradation remains equivocal. Of the cysteine protease cathepsins, ca...

Ngày tải lên: 09/08/2014, 14:22

... Rehli* 1 Abstract Background: In mammals, the dynamics of DNA methylation, in particular the regulated, active removal of cytosine methylation, has remained a mystery, partly due to the lack of appropriate model systems ... demethylation processes implies the presence of demethylating enzymes that actively remove either the methyl group, the methylated cytosine or who...

Ngày tải lên: 09/08/2014, 20:22

... deliberate policy of upgrading the nursing capacity linked to the PROFAE and P ROFAPS policy initiatives. These intitatives are two key pro- grams in relation to scaling up, and are examples of Brazil’s ... the realities of HRH. Those involved had a vision for the future which was tempered byanappreciationofthe practical realities of implementing strategy. They were thinking...

Ngày tải lên: 18/06/2014, 17:20

... the trial upon the pooled expectation for the RCT arms and not upon the value of any single arm. The principle of ‘equal uncertainty between the arms of the RCT’ must be replaced with the principle ... uncertainty in the collective conventional scientific wisdom, in the patient community, or in the mind of the potential participant or of an individual p...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 09/08/2014, 06:22