Báo cáo y học: "Immune regulation of bone loss by Th17 cells" doc

... progression of structural damage of the joint bone structure as measured by X-ray analysis. The RA joint synovial fluid and synovium contain a variety of hematopoeitic cells that are in direct proximity ... for massive H + transport performed by the vacuolar (V-type) Review Immune regulation of bone loss by Th17 cells Iannis E Adamopoulos and Edward P Bowman Department...

Ngày tải lên: 09/08/2014, 13:21

... telomerase activity was measured by TRAP/EIA cells 3 days later. (C) Telomerase activity after introduction of antisense oligonucleotides into PHA- stimulated lymphocytes. Ficoll-Hypaque isolated lymphocytes ... inhibition of TEP1 function by high concentra- tions of antisense oligonucleotides, telomerase activity was dramatically diminished. Alternatively, hTR and hTERT may play a...

Ngày tải lên: 17/03/2014, 23:20

... ossification by which bones form directly from condensations of mesenchymal cells without a cartilage intermediate. Bone formation is a highly regulated process involving the differentiation of mesenchymal ... collagen type 1a1. In the skeletal elements of E18.5 Osx-null embryos the number of TRAP-positive cells appear to be reduced compared to wild-type embryos. In long bones of...

Ngày tải lên: 20/06/2014, 04:20

... to bind to Tyr757 of gp130, Tyr985 of the leptin receptor and Tyr401 of the erythropoietin receptor, Tyr729 of the granulocyte colony-stimulating factor (G-CSF) receptor, Tyr800 of the IL-12 ... 279: 54708-54715. 66. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP: Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and...

Ngày tải lên: 09/08/2014, 06:23

... currently not known. The high degree of sequence similarity between the CTE-I and MTE-I genes suggests that they diverged relatively recently by gene duplication, possibly by duplica- tion of an ... aim ofthis studywas to characterize the role of an acyl-CoA thioesterase (ARTISt) and an acyl-CoA synthetase as members of an alternative pathway in the regulation of the intracell...

Ngày tải lên: 08/03/2014, 09:20

... stress by redirect- ing t he synthetic machinery towards the synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA ... they often catalyze the reduction of pr otons with a high specific activity to yield hydrogen [16]. Interestingly, Fe-hydrogenases were not found in cyanobacteria, the free-living ances...

Ngày tải lên: 08/03/2014, 22:20

... differen- tiation in erythroid progenitors. Polycytemia vera is a clonal myeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells. Sixty percent of polycytemia ... structure of many of these factors variegate the complex regulation of erythropoiesis. ACKNOWLEDGEMENTS Chava Perry MD, is the incumbent of a basic research fellowship...

Ngày tải lên: 08/03/2014, 22:20

... The bone had marrow-like tissue in the center of the bone tissue mass. The bone tissue was composed primarily of compact bone. The osteoblasts were typically arranged in the outer surface of ... in their case report of pleomorphic adenoma with bone formation that the bone matrix was deposited directly by the metaplastic myoepithelial cells rather than by endochond...

Ngày tải lên: 08/08/2014, 16:23

... mediated primar- ily by chondrocytes, by synovial fibroblasts and on occa- sion, by osteoclasts [7,10–12]. The interstitial collagens (types I, II and III), are the princi- ple targets of destruction, ... usually produced only by cartilage and bone during development, and by chondro- cytes in osteoarthritis (OA) [6–8]. Expression of MMPs is low in normal cells, and these low l...

Ngày tải lên: 09/08/2014, 03:24

... cartilage, key compo- nents of the skeletal system. Its metabolism is characterized by two opposing processes: formation and resorption. Typically, diseases of bone are characterized by an alteration ... MRI. We hypothesized that if bone marrow lesions are areas of accelerated bone turnover, then they should be accompanied by elevation in systemic levels of bone turnover...

Ngày tải lên: 09/08/2014, 13:21