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Báo cáo y học: "Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab" ppt

Báo cáo y học:

Báo cáo y học: "Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab" ppt

... given autoantibody or immunoglobulin ana-lyte, synovial/serum index (SSI) was defined as the ratio of synovial analyte/synovial albumin divided by the ratio of serumanalyte/serum albumin.Open ... compensate for any effects of rituxi-mab. More likely, however, and in light of the recent finding that the size and number of synovial lymphoid aggregates in RA areunaltered early after rituximab ... antibody synthesis to the pathogenesis of RA, their applicability in interventional biopsy-based clinical tri-als is limited. Synovial tissues obtained by arthroscopy or nee-dle biopsy typically...
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Báo cáo y học: " Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis" pps

... by the cross-sectional nature of the analysis, and the discrepancymay be the result of random variability. Importantly, a singlemeasurement of inflammatory cytokines is not representative of ... coro-nary plaques, thereby precipitating acute thrombosis and clinical CV events [13]. Interestingly, atherosclerotic plaque and rheumatoid synovium share an array of inflammatory cells and cytokines ... glucocorticoids and nonsteroidal anti-inflammatorydrugs), and the debilitating effect of joint pain and stiffness onphysical activity and fitness. In most studies of CVD in RA, differences in the prevalence...
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Báo cáo y học: "Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1" doc

... tobe increased. Both of these results — the effects on the IL-6/sIL-6R pathway and on IGF-1 in the endocrine system — maybe involved in the mechanisms mediating the beneficialeffects of HRT. There ... significantly in the HRTgroup. Furthermore, the change in E2 in serum wasinversely, though modestly, correlated with the change in sIL-6R. The change of sIL-6R was inversely associated with increase ... radioimmunoassay (Clinical AssaysTM,DiaSorin, Vercelli, Italy) at baseline and yearly thereafter.BMD in the left total hip and lumbar spine was measuredby dual-energy x-ray absorptiometry (DXA) with...
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Báo cáo y học: "Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia" pptx

... A: Induction by inter-leukin-7 of lymphokine-activated killer activity in lymphocytesfrom autologous and syngeneic marrow transplant recipientsbefore and after systemic interleukin-2 therapy. ... BL: Morbidity and mortality in rheumatoid arthritis patients with prolonged and profoundtherapy-induced lymphopenia. Arthritis Rheum 2001,44:1998-2008. Arthritis Research & Therapy Vol 7 No ... grown, in accord-ance with standard techniques [34,35]. By allowing the for-mation of an adherent layer consisting mainly of macrophages and cells of mesenchymal origin, this culturesystem...
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Báo cáo y học:

Báo cáo y học: "Interleukin-7 deficiency in rheumatoid arthritis" ppsx

... basis for the prolonged lymphopenia of CD4+T cells after lymphocyte-depleting therapyspecifically of patients with RA in comparison with otherdisorders, and report that interleukin-7 (IL-7) ... fibroblast-likesynoviocytes are also relevant in RA pathogenesis and represented in synovium/pannus [5]. The accessibility of synovial fluid has permitted the documentation of elevatedlevels of cytokines, including ... including pro-inflammatory cytokinessuch as IL-1, TNF-α, and IL-6 and a large range of others[5]. The evidence in support of an immune basis has led tolympho-depleting therapies, including,...
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Báo cáo y học: "egulatory T cells in rheumatoid arthritis" ppsx

... downmodulation of the inflammation, thereby delaying further tissue damage and impeding erosive inflammation. These findings might be of relevance in validating and fostering the development of clinical ... selectively recruited to and retained in the rheumatoid joint through interactions involving CXCR4. In line with the hypothesis that CD4+CD25+T cells areeffectively recruited to sites of chronic inflammation,CD25+CD4+T ... mightexpand locally in the rheumatoid joint. However, in the rheumatoid synovium it was found that T cells display lowproliferative responses [49], and in patients with JIA the T cells in the synovial...
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Báo cáo y học: "Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis" pot

... radiological scores at year (i + 1) versus the scores year (i) using the differences of year 2 minus year 1, of year 3 minus year 2, and of year 4 minus year 3; each subjecttherefore contributed ... significantly associated with the progression of the joint space narrowing score over the following year (for exam-ple, a relative increase of 6.4% in the joint space narrowingscore during the next year ... biomarker assays may be of use in distinguishing RA patients with rapid progressive and slow progressive joint damage, and may help to identify the severity of joint disease resulting in radiographic...
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Báo cáo y học:

Báo cáo y học: "proximal interphalangeal joints in rheumatoid arthritis: a comparison with magnetic resonance imaging, conventional radiography and clinical examination" pdf

... Ultrasono-graphic and clinical findings agreed on the presence of signs of inflammation in 103 joints (21% of the 480 joints) and on the absence of signs of inflammation in 268 joints (56%). In 91joints ... joint effusion in any of the examinedfinger joints, whereas ultrasonography revealed joint effusion in 22 out of the 433 examined finger joints.Signs of inflammation on ultrasonography (joint ... joints, stratified by imaging modality and combinations thereofJoint Joints with signs of synovitisJoints with no signs of synovitis on US or MRINumber of joints examinedAgreement: US...
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Báo cáo y học: "TH-17 cells in rheumatoid arthritis" pdf

... inducing a variety of pro-inflammatory media-tors, including cytokines, chemokines and other mediators of bone and cartilage destruction in synovial fibroblasts, mono-cytes, macrophages and ... modulate the presence of TH-17 cells in RA.IntroductionInterleukin (IL)-17 may play a critical role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is capable of promotinginflammation by inducing ... to determine the level of interleukin (IL)-17 cytokine in RA, osteoarthritis (OA) and normal synovialtissue, as well as to examine SF macrophages for the presence of IL-23, IL-27 and interferon...
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Báo cáo y học: "Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations" pptx

... whether circulating plasma cytokine profileswere associated with clinical involvement in SSc, plasmacytokines in patients with and without interstitial lung disease,pulmonary hypertension, SSc ... associated with alterations in distinct plasma cytokine levels.Collectively, these data bring to light the complex immun-opathogenesis of SSc and echo the clinical heterogeneity thatis seen within ... IL-23. Effect of disease duration on cytokine profiles in scleroderma patientsImmune dysregulation is commonly thought to be important in the early pathogenesis of SSc. Whether the cytokine altera-tions...
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