... inducing a variety of pro-inflammatory media-tors, including cytokines, chemokines and other mediators of bone and cartilage destruction in synovial fibroblasts, mono-cytes, macrophages and ... modulate the presence of TH-17 cells in RA.IntroductionInterleukin (IL)-17 may play a critical role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is capable of promotinginflammation by inducing ... to determine the level of interleukin (IL)-17 cytokine in RA, osteoarthritis (OA) and normal synovialtissue, as well as to examine SF macrophages for the presence of IL-23, IL-27 and interferon...