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Báo cáo y học: "The relationship between inflammation and new bone formation in patients with ankylosing spondylitis" docx

Báo cáo y học:

Báo cáo y học: "The relationship between inflammation and new bone formation in patients with ankylosing spondylitis" docx

... articleThe relationship between inflammation and new bone formation in patients with ankylosing spondylitisXenofon Baraliakos1, Joachim Listing2, Martin Rudwaleit3, Joachim Sieper3 and Juergen ... nature and the length of the time interval between inflam-mation and new bone formation are unclear. Animal modelsimply that new bone formation in AS is mainly due to 'responseto an inflammation- based ... spinal inflamma-tion and new bone formation are both uncoupled and linked in AS since (a) the majority of syndesmophytes developed with- out MRI evidence of spinal inflammation at BL and (b)...
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Báo cáo y học: "Clinical response to discontinuation of anti-TNF therapy in patients with ankylosing spondylitis after 3 years of continuous treatment with infliximab" ppsx

... Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Function Index; BASMI, Bath Ankylosing Spondylitis Metrology Index; CRP, C-reactive protein; ESR, erythrocyte ... activity) or >6 mg/l (thin line; increased disease activity). AS, ankylosing spondylitis; ASAS, Assessments in Ankylosing Spondylitis [working group]; BASDAI, Bath Ankylosing Spondylitis ... to indicating anacceptable state.ConclusionTherapy with infliximab has definite long-term clinical effi-cacy and safety in patients with AS. Patients who discon-tinue therapy are likely to...
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Báo cáo y học: "The relationship between cancer and rheumatoid arthritis: still a large research agenda" ppsx

... PTPN22,STAT4). Finally, the clinical relevance of these data regardingRA and malignancy is unclear. Should clinicians screen RA patients differently than typical patients? Competing interestsThe ... understanding of malignancy in RAforward but raises many important questions for futureresearch. First, as much of the literature they cite (and most ofthe patients included in the meta-analysis) ... malignancies in RA patients, thereby suggesting agenetic link between these diseases. Second, in the case oflung cancer it would be very useful to improve the control forpotential confounding introduced...
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Báo cáo y học: "The relationship between antipsychotic medication adherence and patient outcomes among individuals diagnosed with bipolar disorder: a retrospective study" doc

... outcomes, without artificially compelling a linear relationship between MPR and outcomes, or arbitrarilydetermining that any particular MPR threshold is appro-priate. All analyses were conducted using ... even ifthey were fully compliant with their prescribed therapy.Finally, this study focused on both atypical and conven-tional antipsychotics, without controlling for class orexact type of medication. ... noncompliance in euthymic bipolar patients. J Clin Psychiatry 2000, 61:549-555.14. Lehmann SW, Rabins PV: Factors related to hospitalization in elderly manic patients with early and late-onset bipolar...
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Báo cáo y học: "The relationship between predicted peptide–MHC β class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model" pptx

... proline isinhibitory at P4 and P9. These constraints allow for fewglycine–proline combinations that will permit interaction between peptide and the DR4 binding groove.The immunogenicity of ... (remov-ing a single methylene group) within a hemoglobin peptidebound by I-Ekinduced a significant variance in the peptidemain chain between P5 and P8, and changed the rotamerconformation ... amino-terminus to carboxyl-terminus. Underlined amino acids indicate the predicted residues thatinteract with the MHC binding groove from P1 to P9. DR4 bindingscores were calculated according...
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Báo cáo y học: "The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study" docx

... critical informationregarding clinical factors associated with pain severity, theydid not quantify the patients& apos; underlying pain sensitivity or yieldinformation about pain mechanisms.Pain ... anti-inflammatorytherapy, rheumatoid arthritis (RA) patients continue to rate painas a priority. The etiology of RA pain is likely multifactorial,including both inflammatory and non-inflammatory components. In ... this study, we examined the relation between dis-ease activity, sleep, psychiatric distress and pain threshold in RA patients. We hypothesized that both inflammatory and non-inflammatory factors...
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Báo cáo y học: "The relationship between the rate of melatonin excretion and sleep consolidation for locomotive engineers in natural sleep setting" pptx

... periods in a sleep diary and collected urine samples during each day's main sleepperiod. The samples were subsequently assayed for the metabolite of melatonin in urine, 6-sulphatoxymelatonin ... studies linking melatonin production and sleep propensity [12-18], and evidence demonstrating the relationship between sleep consolidation and melatoninproduction in a forced desynchrony protocol ... sleeps initiated at night.Conclusion: Combined with previous studies linking melatonin production and sleep propensity, and others demonstrating the relationship between sleep consolidation and...
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Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"

... autonomic nervous system, including the brain stem, spinal cord, hypothalamus and cerebral cortex. Demyelinating plaques may disrupt reflex pathways in the insular, cingulated and ventromedial ... inflammatory de-myelinating disease of the central nervous system (CNS) that is a leading cause of disability in young adults. Autonomic dysfunction is commonly seen in patients with MS (1-5). In patients ... activity per-formed. Many patients complain of feeling exhausted on waking, even if they have slept soundly. Fatigue can also occur during the day but may be only par-tially relieved by rest. In...
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Báo cáo y học: "β A randomized, controlled trial of interferon-β-1a (Avonex®) in patients with rheumatoid arthritis: a pilot study [ISRCTN03626626]" pptx

... lymphocytes. Involvement ofVLA-4 and inhibition by interferonbeta-1b. J Clin Invest 1997,100:604-612.5. Coclet-Ninin J, Dayer JM, Burger D: Interferon-beta not onlyinhibits interleukin-1beta and ... number of patients for this study,we did obtain important safety and efficacy information.The primary outcome of the study was safety. IFN-β-1awas generally well tolerated by these RA patients. ... of the study agent), includ-ing flu-like symptoms occurring after the injections. Theadverse events occurred with similar frequency in patients receiving IFN-β-1a and those receiving placebo....
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Báo cáo y học: "DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis" pps

... Activity Score and theDAS28. In a study performed in Italy in the late 1990s, it wasfound that the Disease Activity Score was the best measureto discriminate between predefined states of low and ... advantageto use a continuous measure with absolute values to measuredisease activity in daily clinical practice and clinical trials.ConclusionThe study of Vander Cruyssen and colleagues confirms ... activity and to titrate treatment with biologicals [8].Competing interestsThe author(s) declare that they have no competing interests.References1. Vander Cruyssen B, Van Looy S, Wyns B, Westhovens...
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