Báo cáo y học: "Are biologics more effective than classical disease-modifying antirheumatic drugs" pot

... introduction of biologics the question arises of whether these – far more expensive – drugs are more effective than synthetic DMARDs. This topic was recently addressed in a well-designed systematic ... and with improved productivity. On the basis of the present evidence it therefore cannot be concluded definitively that biologics are more clinically effective than synthetic...

Ngày tải lên: 09/08/2014, 11:20

... the very early introduction of disease-modifying therapy inhibits progressive structural damage maximally. Clinicians exploiting this ‘window of opportunity’ therefore require very early indicators ... 1995, 34:1102-1104. 14. Schumacher HR. Synovial fluid analysis and synovial biopsy. In Textbook of Rheumatology. Edited by Kelley WN, Harris ED, Ruddy S, Sledge CB. Philadelphia: WB Saunders...

Ngày tải lên: 09/08/2014, 01:23

... radiography, respectively. Of the quadrants with erosions on MRI, US and radiography, 53, 33 and 15, respectively, could be confirmed by CT. For radiography, the overall sensi- tivity, specificity and ... radiography and CT is based on attenuation of X- rays, and bone and other calcified tissues are easily depicted because of markedly higher X-ray attenuation by these tissues than by the su...

Ngày tải lên: 09/08/2014, 08:22

... only on lym- phocytes, but also on monocytes and dendritic cells. Its ligand, IL-7, is a pivotal cytokine involved in the development and sur- vival of T and B lymphocytes [14]. In addition, thymic ... naturally occurring reg- ulatory T cell; PBMC: peripheral blood mononuclear cell; PE: phycoerythrin; SLE: systemic lupus erythematosus; Teff: effector T cell; Treg: regulatory T cell; TSLP: th...

Ngày tải lên: 09/08/2014, 14:22

... of interest not only for the insights they provide into the molecular pathways of piRNA produc- tion, but also because they imply that Hsp90 prevents phenotypic variation by suppressing de novo ... allows the accumulation of ‘cryptic genetic variation’ caused by mutations that do not affect the phenotype. Canalized traits are pheno- typically expressed only in particular environments or .....

Ngày tải lên: 09/08/2014, 20:21

... laboratory signs of inflammation may be caused not only by infection, but also by tissue injury and mainly by the systemic inflammatory response syndrome (SIRS) associated with cardiopulmonary bypass ... short-term mortality and morbidity in patients undergoing coronary artery bypass graft surgery. J Am Coll Cardiol 2002, 40:418–23. 23. Furnary AP, Wu Y, Bookin SO: Effect of hyperglyce...

Ngày tải lên: 10/08/2014, 09:22

... Evaluating the safety of cardiopulmonary resuscitation using a human cadaveric model Douglas R McKay 1* , Hosam F Fawzy 2 , Kathryn M McKay 3 , Romy Nitsch 4 , James L Mahoney 5 Abstract Background: ... major vascular surgery places a patient at a higher risk for perioperative cardiac events and is highest for coronary artery surgery [7]. Those who dehisce sternotomy wounds may do so as the r...

Ngày tải lên: 10/08/2014, 09:22

... item and one fidelity item. Podiatrists with more than three years experience reported a greater increased confidence in their ability to refer patients appropriately for hypergly- caemic management, ... standardised high quality delivery of FUST in most clinical training environments. Simulation training in healthcare is consistently rated by participants as a highly effective and enjo...

Ngày tải lên: 10/08/2014, 21:24

... 1,6-bisphosphatase aldolase 4 GlyA Serine hydroxymethyltransferase 5 LpdA* (AtpA) Lipoamide dehydrogenase (F1 ATP synthase a subunit) 6 Ppa* (AhpC) Inorganic pyrophosphatase (alkyl hydroperoxide reductase ... proteins, cells were lysed in lysis buffer containing 0.2 mgÆmL )1 lysozyme, 0.2 m M phenylmethanesulfonyl fluoride and 1 m M dithiothreitol, followed by sonication. The cell lysates were...

Ngày tải lên: 22/02/2014, 04:20

... affording, typically, an activity of 0.03 U GaDHÆmL extract )1 (0.12 U GaDHÆg )1 ). Affinity chromatography evaluation of the amino-alkyl- dyes, hydrophilic spacer-dye and control-dyes using GaDH ... activity was determined. Table 4. Affinity chromatography evaluation of immobilized mimodyes and hydrophilic spacer-VBAR dye for binding GaDH activity from P. fluorescens crude extract. Dye-ligand .....

Ngày tải lên: 08/03/2014, 09:20