Báo cáo y học: "Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis" pps

... the pathogenesis of RA and other inflammatory diseases, a great deal of interest exists in understanding the molecular basis of the signalling pathways induced by these receptors, with the hope of identifying ... adaptive immune systems in the pathology of the disease. The success of anti-tumour necrosis factor-α indicates the importance of pro-inflammato...

Ngày tải lên: 09/08/2014, 10:23

... & Therapy October 2005 Vol 7 No 5 Meyer and Pap at the same time they strengthen the concept of p38 and ERK as important MAPKs in the inflamed synovium. In line with previous data, the results ... MAPK kinases (MKKs), which largely determine the balance of MAPK activation in response to inflammatory stimuli [8,9]. The second interesting observation by Goertz and coll...

Ngày tải lên: 09/08/2014, 07:20

... only. Similarly, the ET-1-induced NO production was partially suppressed by the p38 kinase inhibitor and was completely suppressed by the protein kinase A kinase inhibitor KT5720 and by LY83583, ... tran- scription of several proinflammatory genes [28,30], inter- acts with the cysteine residues of many proteins (S nitrosylation) and may alter their structure and function. In th...

Ngày tải lên: 09/08/2014, 06:22

... immune system. Further studies will show whether these mutations are actually able to trigger autoimmune inflammation in rheumatoid arthritis or whether they must be considered epiphenomena of ... (germline) mutations of mtDNA. They comprise a wide spectrum of clinical symptoms that arise as a result of dysfunction of the mitochondrial respiratory chain, mostly affecting tis...

Ngày tải lên: 09/08/2014, 07:20

... in which male mice are treated with the alkylating agent ethinyl- nitrosourea, causing point mutations in sperm DNA. Offspring of these mice carry these mutations. By screening thousands of offspring ... require computation of risk from combinations of markers. The current capacity of these tests to predict fracture is illustrated in Figure 1. Using the findings from th...

Ngày tải lên: 09/08/2014, 10:23

... of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: CJC, LIH. Acquisition of data: CJC, LIH, WPC, YHC, ... Huang YK, Chen YT, Hsueh YM: Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area. Toxicol Appl Pharmacol 2008, 226:14-21. 19. Huang Y...

Ngày tải lên: 10/08/2014, 05:21

... destination therapy. Rarely, the sustained unloading provided by the LVAD has led to cardiac reverse remodelling and recovery, permitting explantation of the device. We describe the clinical ... Karaye, K.M., Right ventricular systolic function in peripartum and dilated cardiomyopathies. European journal of echocardiography : the journal of the Working Group on Echocar...

Ngày tải lên: 10/08/2014, 09:22

... RBD- containing central domain is involved in the protein self-interactions. Interestingly, preliminary studies show that N-glyco- sylation may modulate binding of the nucleolin-derived protein to ... Anti-nucleolin). Purity of pro- teins in preparations was estimated at over 95%. Characterization of the glycosylation of recombinant proteins In order to check the occupan...

Ngày tải lên: 14/03/2014, 23:20

... assessed jointly, the elimination of any one of them would not increase the feasibility of calculating the score. In a cross-sectional analysis of a large number of patients, the CDAI not only had correlational ... a disease of the joints, and joint counts can always be per- formed at the time of patient visit to the clinic by the physician or another assessor....

Ngày tải lên: 09/08/2014, 06:22

... as the G a0 -coupled receptor, may play a role in the prosaposin-triggered signal pathway leading to ERK phosphorylation. Indeed, in other cell systems, activation of the MEKK–JNK–cJun signalling ... protein (LRP-1) [8]. The presence of lipid-binding domains in prosaposin and saposins has been well demonstrated [9], and a Keywords lipid domains; PC12 cells; prosaposin; ra...

Ngày tải lên: 24/03/2014, 00:21