Báo cáo y học: "Genetic studies in osteoporosis - the end of the beginning" docx

... in which male mice are treated with the alkylating agent ethinyl- nitrosourea, causing point mutations in sperm DNA. Offspring of these mice carry these mutations. By screening thousands of offspring ... require computation of risk from combinations of markers. The current capacity of these tests to predict fracture is illustrated in Figure 1. Using the findings from th...

Ngày tải lên: 09/08/2014, 10:23

... sus- ceptibility, given the role played by CTLA-4 (cytotoxic T-lym- phocyte associated 4) in T-cell activation and that a CTLA- 4- IgG1 fusion protein is very effective in treating RA [62]. The Table ... significance of the interaction was determined using the Wald χ 2 test of the interaction variable. In the combined NHS-NHSII nested case-control study data- set, we...

Ngày tải lên: 09/08/2014, 10:23

... statistical power of the stud- ies and 2) small size of the studies. Ethnic differences in the roles of the polymorphism may be caused by gene-gene interactions, different linkages to the poly- morphisms ... increased risk of lung cancer compared with indi- viduals with the Lys/Lys genotype [51]. The meta-analysis by Benhamou and Sarasin (2005) re- ported that the...

Ngày tải lên: 31/10/2012, 14:59

... these findings indi- cate that there is constancy in the epidemiologic charac- teristics of ankylosing spondylitis. The incidence and prevalence of ankylosing spondylitis has also been studied in ... lupus erythematosus A population-based study examined the incidence and mortality of systemic lupus erythematosus (SLE) in a geographically defined population over a 42-year per...

Ngày tải lên: 09/08/2014, 14:20

... conti- nental group (Table 1). We also evaluated the haplotype diversity in each group by averaging the haplotype het- erozygosity in ten 10-kb non-overlapping windows and Figure 1 SNP discovery in ... uniform sampling of human genetic diversity: A survey of worldwide populations by high-density genotyping. Genomics 2010, 96:19 9-2 10. 20. Xing J, Watkins WS, Witherspoon DJ, Z...

Ngày tải lên: 09/08/2014, 22:23

... association may partly explain the discre- pancies of these studies. The other possibility for these discrepancies may due to markedly difference of e xpo- sure level among these studies. We noticed the ... Taiwan Ling-I Hsu 1 , Wu-Ping Chen 1 , Tse-Yen Yang 1 , Yu-Hsin Chen 1 , Wann-Cheng Lo 1 , Yuan-Hung Wang 2,3 , Ya-Tang Liao 4 , Yu-Mei Hsueh 2 , Hung-Yi Chiou 2 , Meei-Maan Wu...

Ngày tải lên: 10/08/2014, 05:21

... AGE-age in years; TC- total cholesterol; HDL-high density lipo- protein; LDL-low density lipoprotein; VLDL-very low density lipoprotein; TG-triglycerides; AP-alkaline phosphatase. (* signifi- cant ... meva- lonate pathway in patients with SCRC depending on the location of the tumour in the large intestine [31]. The use of LR for the observational studies continues t...

Ngày tải lên: 03/11/2012, 11:34

... anti-(phosphotyrosine-STAT3) Ig or anti-(phosphotyro- sine-STAT5) Ig. The data are displayed after subtractio n of the background derived from isotype control staining and nonspecific binding of the second ... (1992) The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 bindin g and signaling by mechanisms...

Ngày tải lên: 17/03/2014, 23:20

... survivin. Moreover, in a multivariant model we showed that the role of survivin is independent of the pres- ence of RF, the duration of the rheumatic disease, and gender. Interestingly, survivin ... expression of sentrin-1 [11]. Sentrin-1/SUMO is a molecule whose binding to a protein results in the prevention of ubiquitin-related processing and degradation of that...

Ngày tải lên: 09/08/2014, 06:22

... P, Helve T, et al.: Delay to institution of therapy and induction of remis- sion using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis ... combination group, but by only 25% in the monotherapy groups. The results of these studies show that TNF-blocking drugs, used either in combination or as monotherapy, have a...

Ngày tải lên: 09/08/2014, 10:20