Báo cáo y học: "Genetic studies in osteoporosis - the end of the beginning" docx
Báo cáo y học: "Genetic studies in osteoporosis - the end of the beginning" docx
... in which
male mice are treated with the alkylating agent ethinyl-
nitrosourea, causing point mutations in sperm DNA. Offspring
of these mice carry these mutations. By screening thousands
of offspring ... require
computation of risk from combinations of markers. The
current capacity of these tests to predict fracture is illustrated
in Figure 1. Using the findings from th...
Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
... sus-
ceptibility, given the role played by CTLA-4 (cytotoxic T-lym-
phocyte associated 4) in T-cell activation and that a CTLA- 4-
IgG1 fusion protein is very effective in treating RA [62]. The
Table ... significance of the interaction was
determined using the Wald χ
2
test of the interaction variable.
In the combined NHS-NHSII nested case-control study data-
set, we...
Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... statistical power of the stud-
ies and 2) small size of the studies. Ethnic differences
in the roles of the polymorphism may be caused by
gene-gene interactions, different linkages to the poly-
morphisms ...
increased risk of lung cancer compared with indi-
viduals with the Lys/Lys genotype [51]. The
meta-analysis by Benhamou and Sarasin (2005) re-
ported that the...
Báo cáo y học: "Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases" pps
... these findings indi-
cate that there is constancy in the epidemiologic charac-
teristics of ankylosing spondylitis.
The incidence and prevalence of ankylosing spondylitis has
also been studied in ... lupus
erythematosus
A population-based study examined the incidence and
mortality of systemic lupus erythematosus (SLE) in a
geographically defined population over a 42-year per...
Báo cáo y học: "Genetic diversity in India and the inference of Eurasian population expansion" doc
... conti-
nental group (Table 1). We also evaluated the haplotype
diversity in each group by averaging the haplotype het-
erozygosity in ten 10-kb non-overlapping windows and
Figure 1 SNP discovery in ... uniform sampling of human genetic diversity: A survey
of worldwide populations by high-density genotyping. Genomics 2010,
96:19 9-2 10.
20. Xing J, Watkins WS, Witherspoon DJ, Z...
Báo cáo y học: " Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan" ppt
... association may partly explain the discre-
pancies of these studies. The other possibility for these
discrepancies may due to markedly difference of e xpo-
sure level among these studies. We noticed the ... Taiwan
Ling-I Hsu
1
, Wu-Ping Chen
1
, Tse-Yen Yang
1
, Yu-Hsin Chen
1
, Wann-Cheng Lo
1
, Yuan-Hung Wang
2,3
, Ya-Tang Liao
4
,
Yu-Mei Hsueh
2
, Hung-Yi Chiou
2
, Meei-Maan Wu...
Báo cáo y học: "Multivariate explanatory model for sporadic carcinoma of the colon in Dukes’ stages I and IIa"
...
AGE-age in years; TC- total cholesterol; HDL-high density lipo-
protein; LDL-low density lipoprotein; VLDL-very low density
lipoprotein; TG-triglycerides; AP-alkaline phosphatase. (* signifi-
cant ... meva-
lonate pathway in patients with SCRC depending on
the location of the tumour in the large intestine [31].
The use of LR for the observational studies
continues t...
Báo cáo Y học: GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines doc
... anti-(phosphotyrosine-STAT3) Ig or anti-(phosphotyro-
sine-STAT5) Ig. The data are displayed after subtractio n of the
background derived from isotype control staining and nonspecific
binding of the second ... (1992) The interleukin 2 receptor (IL-2R): the
IL-2R alpha subunit alters the function of the IL-2R beta subunit
to enhance IL-2 bindin g and signaling by mechanisms...
Báo cáo y học: "Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis" ppt
... survivin. Moreover, in a multivariant model we
showed that the role of survivin is independent of the pres-
ence of RF, the duration of the rheumatic disease, and
gender. Interestingly, survivin ... expression of sentrin-1
[11]. Sentrin-1/SUMO is a molecule whose binding to a
protein results in the prevention of ubiquitin-related
processing and degradation of that...
Báo cáo y học: "Biological therapy in early arthritis – overtreatment or the way to go" pptx
... P, Helve T,
et al.: Delay to institution of therapy and induction of remis-
sion using single-drug or combination-disease-modifying
antirheumatic drug therapy in early rheumatoid arthritis.
Arthritis ... combination group, but by only 25% in
the monotherapy groups.
The results of these studies show that TNF-blocking drugs,
used either in combination or as monotherapy, have a...
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