Báo cáo y học: "TH-17 cells in rheumatoid arthritis" pdf

... selectins and integrins on synovial endothelium, allowing migration up chemotactic gradients into the joint. The composition of inflammatory cells recruited in a continuing fashion by mast cells, including ... the synovial mesenchyme The synovial mesenchyme, consisting principally of synovial fibroblasts, is prominently involved in joint inflammation. Fibroblasts increase greatly in...

Ngày tải lên: 09/08/2014, 01:24

... the amount of synovium infiltrating cells, including plasma cells [39]. Because RF-producing cells are present in inflamed rheumatoid synovium and the local environment may favour synovial RF production ... phenomenon, lasting about 1 year. This might explain why almost all of the infliximab-induced lupus syn- dromes were reported within the first year of treatment in RA. No differ...

Ngày tải lên: 09/08/2014, 01:23

... the cytokine network in such induction has already been demonstrated for another cytokine, interferon γ, inducing the development of autoan- tibodies in patients with hepatitis C viral infection ... complement- dependent cellular cytotoxicity of the cells expressing the cytokine [37]. Furthermore, infliximab has been shown to increase the number of apoptotic T lymphocytes in the lam-...

Ngày tải lên: 09/08/2014, 01:24

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... highly dif- ferentiated state [11–16]. These inflammatory chemokine receptors are prominently expressed on effector T lymphocytes (Th1 cells) that mediate a type 1 inflammation such a...

Ngày tải lên: 09/08/2014, 03:24

... CD19 + B cells is dependent on HLA DRB1 In the initial, retrospective study, the frequency of B cells was determined as a percentage of CD19 + lymphocytes from total T lymphocytes and B lymphocytes ... The clinical relevance of B lymphocytopenia in SE-positive RA will be further investigated in longitudinal studies. Keywords: antibodies, B lymphocytes, major histocompatibility compl...

Ngày tải lên: 09/08/2014, 03:24

... RA-induced and RA therapy-induced hyperhomocysteinemia to CHF risk in RA has yet to be completely elucidated. Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines (TNF-α, ... an endocrine (originating in the synovium) or paracrine (produced in the local environment of the progressively failing myocardium) fashion, contributing to subclinical and eventual...

Ngày tải lên: 09/08/2014, 07:20

... A, et al.: Min- imal clinically important difference in radiological progression of joint damage over 1 year in rheumatoid arthritis: preliminary results of a validation study with clinical experts. ... 3 Probability plot: change/year in total radiographic scoreProbability plot: change/year in total radiographic score. Figure 4 Probability plot: change/year in erosion scoreProbabi...

Ngày tải lên: 09/08/2014, 08:22

... modifications regulating inflammatory processes The transcription factor NF-κB plays a central role in the induction of genes involved in immunity and inflammation, including cytokines, chemokines, adhesion ... regions. Methyl CpG-binding proteins use transcriptional corepressors for transcriptional silencing or may modify the surrounding chromatin of methylated regions [27]. In oncogen...

Ngày tải lên: 09/08/2014, 13:21

... In our study, CT of the sinuses was performed only to investigate symptoms. Sinus aspergilloma may remain asymptomatic for several years, however, and may therefore be underestimated. Sinus involvement ... Aspergillus may be either invasive or noninvasive. Invasive sinus aspergillosis may be indolent or ful- minant. Noninvasive Aspergillus sinusitis may manifest as aller- gic fungal sinusit...

Ngày tải lên: 09/08/2014, 14:22

... anti-citrullinated protein antibodies), which can be found already in the preclinical phase of the disease; the presence of lymphocyte aggre- gates containing B cells, which are often surrounded by large numbers ... plasma cells, in the inflamed synovium; and experimental studies showing, for instance, the effects of immune complexes containing rheumatoid factor on tumor necrosis fact...

Ngày tải lên: 09/08/2014, 14:22