Báo cáo y học: "Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis" ppsx

... HDLs. Processes in addition to proinflammatory high-density lipoproteins that may accelerate atherosclerosis in systemic lupus erythematosus Antibodies may also play a role in the pathogenesis of atherosclerosis, ... inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rh...

Ngày tải lên: 09/08/2014, 10:23

... ligation-induced phosphory- lation of YxxL immunoreceptor tyrosine activation motifs in the cytoplasmic tails of TCRζ and CD3ε, γ and δ chains [12]. By binding to tandemly arranged immunoreceptor tyrosine ... regulatory loop by generating knock -in mouse lines expressing the 75 9Y to F mutation. Commentary Altered signalling thresholds in T lymphocytes cause autoimmune arthritis And...

Ngày tải lên: 09/08/2014, 01:23

... antithro mbin III (synonymous with SERPINC1), and inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4; synonymous with inter-alpha-trypsin inhibitor family heavy chain-related protein, IHRP), ... factor-binding protein 4; IHRP: inter-alpha-trypsin inhibitor family heavy chain-related protein; IPI: international Protein Index; ITIH4: inter-alpha-trypsin inhibitor heavy chain H4; iTRAQ: isoba...

Ngày tải lên: 10/08/2014, 21:23

... or- ganelles and enzymes, increased lipid peroxidation, and development of insulin resistance (7). The vascu- lar and systemic complications in diabetes are associ- ated with hyperglycemia-induced ... revealed that insulin resistance is associated in humans with reduced intracellular antioxidant (11). Interestingly, antioxidants improve insulin sensitivity and help in...

Ngày tải lên: 26/10/2012, 09:39

... positions; and CXC chemokines, with a single amino acid separating the first two cysteines. Cys–X–Cys ligand (CXCL)9 and CXCL10 are members of the small cytokine (intercrine/chemokine) CXC subfamily and ... important roles in directing the migration of immunocompetent cells to sites of inflammation and in determining the pathohistologic outcome of chronic inflammation and syno...

Ngày tải lên: 09/08/2014, 01:23

... heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis. J Biochem (Tokyo) 1997, 122:453-458. 118. Ceponis A, Konttinen ... cells, as shown by in situ hybridisation [120]. There is only scant expression of these enzymes in normal synovia. MMP-3 (stromelysin) mRNA mainly occurs in the lining layer in RA...

Ngày tải lên: 09/08/2014, 01:23

... factor regulating Th2 development, GATA-3. Another interesting and recent finding is that the lack of RUNX3 in a mouse model results in eosinophilic airway inflammation. Interestingly, RUNX3 was ... β 2 -integrins. The findings revealed by the RUNX3 knockout mouse might provide us with some ideas about how the involvement of the RUNX proteins could be explained in systemic lupus...

Ngày tải lên: 09/08/2014, 01:23

... lymphocytes, only very few cells were found in joints during the first week of transfer, and a second cell transfer was needed to induce a significant influx of lymphocytes into the joints and ... phase and during acute inflammation, 127 genes were active both in acute and chronic phases, and 17 tran- scripts shared a common expression pattern in pre- inflamed and chronica...

Ngày tải lên: 09/08/2014, 06:22

... also included time- contingent intake and reduction of medication, increase of bodily activity, reduction of interference of pain with activities, reduction of pain behaviours, and training in ... improvements in pain, physical functioning, and emotional distress in patients with FMS. 2. CBT and OBT will produce significantly greater improve- ments in pain, physical functionin...

Ngày tải lên: 09/08/2014, 08:22

... immunoglobulin synthesis. Both anti-CCP and RF-IgM were significantly enriched in synovial tissues containing lym- phoid aggregates. However, in an 8-week study, autoantibody production in RA synovia ... antibody synthesis to the pathogenesis of RA, their applicability in interventional biopsy-based clinical tri- als is limited. Synovial tissues obtained by arthroscopy or nee- dle b...

Ngày tải lên: 09/08/2014, 13:21