Báo cáo y học: " Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments" docx

... partic- ularly influence incidence and severity of CIA in female mice. These effects are significant in congenic B10.Q female mice carrying heterozygous Cia40 fragments of NFR/N origin. Con- genic mice carrying ... containing Cia40/ Pregq2 congenic female mice and breeding cages containing only wildtype littermate females. The frequency of litters con- taining dead p...

Ngày tải lên: 09/08/2014, 10:23

... [8,9]. Apoptosis is a physiological process and is a highly selec- tive way to eliminate aged and injured cells. In addition to internal pathways that trigger apoptosis mainly in response to cytotoxic ... FasL induced apopto- sis. Our findings point to yet unconsidered effects of mod- ulating proinflammatory cytokines that must be taken into account when novel biological agents su...

Ngày tải lên: 09/08/2014, 01:23

... N, Cinquini M, Magrini L, Tin- cani A, Valesini G: Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid arthritis ... 0.043). To study the reactivation of humoral autoimmunity after immunoablative therapy, we ana- lyzed the avidity of reappearing ACPA-IgG autoantibodies by dichotomizing patients accordi...

Ngày tải lên: 09/08/2014, 10:21

... experimental autoimmune encephalomyelitis (EAE) using myelin and synovial antigen arrays. (a, b) Synovial and (d, e) myelin arrays were produced by printing synovial and myelin peptides and proteins in ... against epitopes derived from MBP, myelin oli- godendrocyte glycoprotein (MOG), myelin-associated glycoprotein, myelin-associated oligodendrocyte basic protein and αB-crystallin. Epitope...

Ngày tải lên: 09/08/2014, 13:22

... consumed by sPLA2. This enzyme is increased in level and activity in some inflammatory diseases and catalyzes hydrolysis of aminophos- pholipids, including PS, as well as phosphatidylcholine and phsophatidylethanolamine, ... the bilayer membrane of MPs contains aminophospholipids, mainly anionic phos- phatidylserine (PS), which is procoagulant and detectable by its binding to annexin...

Ngày tải lên: 09/08/2014, 14:22

... pain sensitivity haplotype'. Diatchenko and colleagues [10] also demonstrated that COMT inhibition in rats results in a dramatic increase in sensitivity to pain. Low COMT activity may increase ... widespread pain and allodynia) could be explained by a pathogenesis known as 'sympathetically maintained pain' [5]. Naturally occurring sympathetic neurotransmitters are cate-...

Ngày tải lên: 09/08/2014, 10:21

... 11), LDL was mea sured directly by Quest Laboratory in Baltimore Maryland USA. CD4 counts were determined with a FACS counter (Becton and Dickinson, Immunocytometry Systems, San Jose, CA, USA) at ... Jensen P, Feingold KR: Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome. J Clin Endocrinol Meta...

Ngày tải lên: 10/08/2014, 05:21

... and developing countries [1,2]. Increased mortality during bacterial pneumonia may have resulted from a failure to control bacterial growth in the lung or to prevent inflammatory injury to the lung. ... model in WT and TLR4 mutant mice, we demonstrate that gut flora are involved in inducing lung inflammatory reaction against bacterial challenge through toll-li ke receptor 4. Ad...

Ngày tải lên: 10/08/2014, 10:20

... apomyoglobin [12], tropomyosin [13] or synthetic proteins [14]. Hydrostatic pressure is increasingly being used in the study of protein folding, misfolding, aggregation and transitions. In comparison ... confor- mational stability was monitored using FTIR spectroscopy, and the functional enzyme stability was monitored by inactivation studies. The enzyme proved to be highly piezostable a...

Ngày tải lên: 07/03/2014, 03:20

... K, Finnegan A: Variations in susceptibility to proteoglycan- induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoim- mune disease. Arthritis ... (p40phox) in rheumatoid factor negative men [82]. This proves that although not all genetic findings in animals can be directly translated to humans, we can identify pa...

Ngày tải lên: 09/08/2014, 01:22