Báo cáo y học: "Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications" doc

... been implanted into critically sized parietal bone defects of skeletally mature mice early (2 weeks), bone regeneration took place, with nearly complete bony bridging by 8 weeks. Winkler and coworkers used ... their natural synergy to regenerate bone in a physiological state. This takes advantage of the endogenous BMP cascade both temporally and spatially [1,4-8]. Also, suppression...

Ngày tải lên: 09/08/2014, 10:23

... member of the family and has been used in many studies for augmentation of bone and bone- ten- don junction regeneration [3,4]. Because of the role of BMP-2 in bone formation, it is commonly found ... 90(2):514-521. 4. Ma CB, Kawamura S, Deng XH, Ying L, Schneidkraut J, Hays P, Rodeo SA: Bone morphogenetic proteins-signaling plays a role in tendon-to -bone healing: a study...

Ngày tải lên: 20/06/2014, 04:20

... stability of apoC-II in the absence of lipid is typical of lipid-free apolipoproteins and may underlie the general propensity of apolipoproteins to form amyloid in vivo [7]. The ability of apoC-II ... concentrations of apoC-II. Amyloid fibril size is reduced by the presence of clusterin The effect of clusterin on the aggregation-state of apoC-II amyloid was investigated by se...

Ngày tải lên: 24/03/2014, 04:21

... models of arthritis [45,46]. Monocytes and macrophages synthesize and release into their environment a variety of cytokines and other proteins that play a central role in the development of acute ... instructions. Statistical analysis All statistical analyses were performed by SigmaStat software (SPSS, Inc., Chicago, IL, USA). Differences between groups were analyzed by one-way analysis...

Ngày tải lên: 09/08/2014, 07:20

... erosions (n = 277) CT Radiography MRI Sensitivity (%) Specificity (%) Accuracy (%) Sensitivity (%) Specificity (%) Accuracy (%) Sensitivity (%) Specificity (%) Accuracy (%) Radius 10 (11) 2 (3) 6 ... showed moderate sensitivity and good specificity and accuracy for detection of erosions in rheumatoid arthritis and healthy wrist bones, while radiography showed very low sensitivity. The teste...

Ngày tải lên: 09/08/2014, 10:23

... fed a soy pro- tein peptic hydrolysate with bound phospholipids, compared to soy protein diet alone or soy protein hy- drolysate [76]. Part of the antiobesity effect of soy protein may be due ... composition of soy protein Soybeans provide one of the most abundant plant sources of dietary protein. The protein content of soybeans varies from 36% to 56% [24-27]....

Ngày tải lên: 31/10/2012, 14:59

... that the process of activation of ACC and p70S6K by amino acids is inhibited by okadaic acid and calyculin A, two inhibitors of type 1 and 2A protein phosphatase, and by incubation of liver cells ... )80 °C. Enzyme assays Methods for the measurements of the activity of AMPK after precipitation with 6% (w/v) polyethylene glycol 6000, of ACC and p70S6K, and for immunoprecipita...

Ngày tải lên: 22/02/2014, 07:20

... Laemmli [32]. Assay of cell-free HA synthesis Cell-free HA synthesis was performed by a modification of the method reported by Nakamura et al. [18]. Analysis of the transfer of UDP-[U- 14 C] GlcUA ... treatment may cause a decrease in hyaluronan synthase activity by altering the lipid environment of membranes, especially the distribution of different cardiolipin species, surrounding...

Ngày tải lên: 08/03/2014, 09:20

... SAPK systems. REGULATION OF SAPK SIGNAL PATHWAYS BY PROTEIN PHOSPHATASES IN YEAST CELLS A molecular g enetic analysis of ye ast cells indicated that two distinct protein phosphatase groups, protein ... activation of SAPKs requires phosphorylation of conserved tyrosine and threonine residues within the catalytic domain. This phosphorylation is mediated by dual specificity protein...

Ngày tải lên: 17/03/2014, 23:20

... formation of disulfide bonds, glycosylation, and proteolytic cleavage. The proteo- lytic cleavage of the precursor protein is achieved by digestion by a proprotein convertase, homologous to yeast subtilisin/kexin ... immediately indicates the possibility of the physiological importance of this fragment, although its fate is currently unknown. The C-peptide, a by-product of proteoly...

Ngày tải lên: 24/03/2014, 03:21