Báo cáo y học: "Low-intensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study" pot
Báo cáo y học: "BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance" ppt
... systematicallymated and an inbred colony was established in 1920 [71]. The original BALB/c colony was separated in 1 935 . One of these colonies was maintained by G. Snell at The JacksonLaboratory ... littermates, and the composition of intestinal bacterial flora)maintained at different locations by the same vendor. Accord-ing to the online public database of The Jackson Laboratory(Bar Harbor, ... about 70 years ago and the correspondingmicroarray results indicate that, indeed, a single or a limitednumber of mutations may dramatically affect the clinical phe-notype of arthritis in BALB/c...
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Báo cáo y học: "Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo" doc
... incubated byan alkaline phosphatase conjugated rabbit anti-rat immu-noglobulin (Dako) and the reaction was visualized using a ratalkaline phosphatase–antialkaline phosphatase complex(Dako), ... and ERK in the synovial membrane, indicating that the intracellular effects of TNF can be inhibited. This suggeststhat anti-TNF therapy reduces key signalling pathways in the synovial membrane, ... USA).Statistical analysisData are expressed as mean ± standard error of the mean.Expression of ERK, p38MAPKα and JNK in the different ther-apy groups and cell types was compared by means of Kruskal–Wallis...
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Báo cáo y học: "1, 25-dihydroxyvitamin D3 decreases adriamycin-induced podocyte apoptosis and loss"
... including Fas, FADD, Bax and Bcl-2 a n d caspase -3 activity were detected. Proteinuria can cause tubular cell apoptosis which is associated with activation of Fas-FADD-caspase 8 pathway (33 ) . Bcl ... aminonucleoside-induced apoptosis of glo-merular podocytes by activating the phosphatidyli-nositol 3- kinase/Akt- signaling pathway. Gassler et al. (12) revealed extensive apoptosis and markedly de-creased ... po-docytopenia induced by adriamycin (ADR) and the potential mechanisms. Materials and Methods Animals and experimental design Forty-eight male Sprague-Dawley (SD) rats were housed in a temperature-controlled...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... activity of nitric oxide synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, ... in- volvement of NO in the pathophysiology of anoxia (hypobaric hypoxia) and reperfusion damage in brain. The increased activities of AS and AL indicate the effective recycling of citrulline to arginine ... GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN M. Swamy, Mohd Jamsani Mat Salleh, K. N .S. Sirajudeen, Wan Roslina Wan Yusof and G. Chandran...
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Báo cáo Y học: A chimeric scorpion a-toxin displays de novo electrophysiological properties similar to those of a-like toxins docx
... G 38 -H-K-S-G-H 43 by the corresponding sequences in LqhaIT wereperformed using the following oligonucleotides: 5¢-GGTTATATTGCCAAGAACTATAACTGTGCATAC -3 ,5¢-CATTGTTTAAAAATCTCCTCAGGCTGCGACACTTT A -3 ,and5 ¢-ACGAGTGGCCACTGCGGACATAAATCTGGACACGGAAGTGCCTGCTGG -3 , ... that the highlyvariable and dynamic C-terminal tail together with the spatially vicinal residues, form the interacting areas onto the surface of scorpion a- neurotoxins. Thus, the C-termini of scorpion ... receptor[45,48–50]. In addition, the spatial arrangement of the toxinpolypeptide chain together with the formation of anelectrostatic potential are also predicted to participate to the capacity of these...
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Báo cáo Y học: Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces docx
... e-aminocaproic acid as a C-ter-minal lysine analog [27]. The kringle-2 domain of tPAdirectly interacts with e-aminocaproic acid [35 ]. Krin-gle-2-mediated tPA binding to the C-terminal lysinesplays ... Abcam (Cambridge, MA, USA);rabbit polyclonal antibody against enolase, mouse mono-clonal antibody against annexin II and rabbit polyclonalantibody against annexin II from Santa Cruz (Santa Cruz,CA, ... by matrilysin.N-terminal sequence analysis of the 35 kDa protein band revealedthat annexin II had been cleaved between Lys9 and Leu10.J. Tsunezumi et al. Cleavage of annexin II by matrilysinFEBS...
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Báo cáo Y học: Na+/K+-ATPase as a signal transducer Zijian Xie and Amir Askari docx
... The signaling pathways that are rapidly elicited by the interaction of ouabain with Na+/K+-ATPase, and are independent of changes in intracellular Na+ and K+concentrations,include activation of ... [Ca2+]iregulates the signaling events initiatedby ouabain. The Ca2+-calmodulin kinase also seems to beinvolved in ouabain-induced activation of MAPK and regulation of early and late-response genes [ 23 25] ... updated in one of the accompanyingreviews [3] . Here, we address a newer aspect of the biology of Na+/K+-ATPase; i.e. the mechanisms and the pathwaysby which the enzyme acts as a signal transducer...
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Báo cáo Y học: Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 potx
... containing HA-tagged hspry4 was constructed.Kinase activity of cotransfected Myc-tagged MAP kinasewas measured by its ability to phosphorylate myelin basic protein and was maximal 2 min after ... of 15 mM 3- amino-1,2,4-triazole and in the absence of the amino acidsleucine, tryptophan and histidine. Full-length humanTESK1 cDNA in pAct2, in frame with the GAL4 activationdomain and the ... factor (FGF)- and epidermal growth factor (EGF)-receptor tyrosine kinase activation and acts asan inhibitor of the ras/MAP kinase pathway downstream of these receptors. By differential display...
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Báo cáo y học: "HIV-1 Capsid Assembly Inhibitor (CAI) Peptide: Structural Preferences and Delivery into Human Embryonic Lung Cells and Lymphocyte" pptx
... building blocks using the LEAP module of the AMBER package [30 ]. Linking of the two chains by forming a disulfide bond between the C-terminal cysteines and folding of the molecule into the starting ... search algorithm can be regarded as very high (see Material and Methods) and are clearly at the limit on what is technically feasible at the moment. The reason why the conformation of CAI as ... program used indicated no or only weak binding. These findings suggest that the binding affinity would dramatically benefit if the free CAI-peptide would have an intrinsic tendency to form an...
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Báo cáo y học: "Subtyping patients with heroin addiction at treatment entry: factor derived from the Self-Report Symptom Inventory (SCL-90)" ppt
... the form of panic anxiety-related symptoms. Anxiety and panic anxiety may belinked with the withdrawal syndrome. The pathophysiol-ogy of withdrawal actually overlaps with that of panic dis-order, ... here, as are addi-tional somatic c signs (for example, 'trembling'). Scalesmeasuring free-floating anxiety and panic attacks are anMaremmani et al. Annals of General Psychiatry 2010, ... those that are observed within the opiate withdrawalsyndrome and are associated with anxiety. Anxiety isagain a major feature in the fourth dimension resultingfrom factorial analysis, in the form...
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