Báo cáo y học: "The renal metallothionein expression profile is altered in human lupus nephriti" doc

... expression profile in systemic lupus erythematosus patients with nephritis. Introduction Systemic lupus erythematosus (SLE) is an immune-inflamma- tory disorder characterized by multiorgan involvement ... healthy kidneys and in lupus nephritisLocalization of metallothionein (MT) isoforms I + II in healthy kidneys and in lupus nephritis. Representative results of immun...

Ngày tải lên: 09/08/2014, 10:23

... recently, Kontoyiannis and Kollias [12], by analyzing TNF-deficient NZB mice, re-estab- lished the finding that TNF deficiency is an important driver of lupus- like autoimmunity in certain strains. ... circulating in lupus sera is bioactive [46]. TNF is evidently overexpressed not only in murine (see above), but also in human lupus nephritis [47-50], and our own data sugg...

Ngày tải lên: 09/08/2014, 10:22

... of low polymorphism or high linkage disequilibrium only if exon density in the region is sufficiently high. Even then, estimating the precise length of the region affected by selection is not possible ... nonsynonymous polymorphism in SLC24A5, a gene that in uences skin pigmentation, is a clear outlier with respect to both interpopulation divergence and patterns of polymorphism...

Ngày tải lên: 09/08/2014, 23:20

... routine incident-reporting systems, but without requiring substantial investments of additional resources. Academic centers are increasingly recognizing engagement in quality improvement as a distinct ... distinct career pathway. Involving such physicians in medical emergency teams will likely facilitate the dual roles of these as a clinical outreach arm of the intensive care unit and in...

Ngày tải lên: 25/10/2012, 10:06

... measured tyrosine phosphorylation of the FcR c-chain and the tyrosine kinase Syk, which is tyrosine phosphorylated and activated early after GPVI engagement. Phosphorylation of FcR c-chain was assessed ... was visualized by incubation with convulxin or an antibody to convulxin, and indirectly labelled with R-phycoerythin-conjugated anti-rabbit IgG. Fluorescent GFP is directly visualized...

Ngày tải lên: 22/02/2014, 07:20

... The minor pathway (30%) involves an association step leading to the incor- rectly folding dimers, prior to the very slow D*fiD folding step. In this study, we have characterized the folding-as- sembly ... several in vitro studies established the above hypothesis [2–6]. These intermediates usually occur in the kinetic pathway of protein folding; however, they are often formed so fast that...

Ngày tải lên: 08/03/2014, 23:20

... substrate binding pocket. Few examples exist in which the ratio between hydrolysis and aminolysis was changed by changing the catalytic nucleophile. By replacing the active- site serine in subtilisin ... property of bF24A is its increased esterase/ amidase ratio. In general the enzyme-catalysed hydrolysis of esters is faster than the hydrolysis of the corresponding amides due to the...

Ngày tải lên: 17/03/2014, 23:20

... brain after single oral administration of fluvoxamine: a positron emission tomography study using [ 11 C]SA4503. Biol Psychiatry 2007, 62:878-883. 26. Bellini L, Gasperini F, Gatti F, Franchini ... SSRIs: human monoamine transporter binding profile of escitalopram and R- fluoxetine. Biol Psychiatry 2001, 50:345-50. 29. Goodnick PJ, Goldstein BJ: Selective serotonin reuptake inhibitors...

Ngày tải lên: 08/08/2014, 23:21

... was diagnosed by histomorphology (in biopsy specimens from skin and bowel or duodenum), and vasculitis, by histo- morphology (skin biopsy) and angiogram. All the patients in this group had joint erosions. The ... the cytolytic proteins perforin and granzyme B and are functionally specialized for cytotoxic activity [17]. Perforin was found in CD4 + CD28 – peripheral blood lym- phocytes, a...

Ngày tải lên: 09/08/2014, 01:22

... glycolytic enzyme G6PI specifically induces arthritis, with no other symptoms of organ-specific or systemic autoimmune disease. Interestingly, although GPI is ubiquitously expressed in the body, ... autoim- munity in mice whose T cell repertoire is shaped by a single antigenic peptide. J Clin Invest 2001, 108:1589-1596. 88. Mathews MB, Bernstein RM: Myositis autoantibody inhibits his-...

Ngày tải lên: 09/08/2014, 06:22