Báo cáo y học: "The renal metallothionein expression profile is altered in human lupus nephriti" doc
Báo cáo y học: "The renal metallothionein expression profile is altered in human lupus nephriti" doc
... expression profile in systemic lupus erythematosus
patients with nephritis.
Introduction
Systemic lupus erythematosus (SLE) is an immune-inflamma-
tory disorder characterized by multiorgan involvement ... healthy kidneys and in lupus nephritisLocalization of metallothionein (MT) isoforms I + II in healthy kidneys
and in lupus nephritis. Representative results of immun...
Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... recently, Kontoyiannis and
Kollias [12], by analyzing TNF-deficient NZB mice, re-estab-
lished the finding that TNF deficiency is an important driver of
lupus- like autoimmunity in certain strains. ... circulating in lupus sera is bioactive [46].
TNF is evidently overexpressed not only in murine (see
above), but also in human lupus nephritis [47-50], and our
own data sugg...
Báo cáo y học: "The promise and limitations of population exomics for human evolution studies" doc
... of low polymorphism
or high linkage disequilibrium only if exon density in the
region is sufficiently high. Even then, estimating the
precise length of the region affected by selection is not
possible ... nonsynonymous polymorphism in
SLC24A5, a gene that in uences skin pigmentation, is a
clear outlier with respect to both interpopulation
divergence and patterns of polymorphism...
Báo cáo y học: "The evolving story of medical emergency teams in quality improvement"
... routine incident-reporting systems, but without requiring
substantial investments of additional resources. Academic centers
are increasingly recognizing engagement in quality improvement as
a distinct ... distinct career pathway. Involving such physicians in medical
emergency teams will likely facilitate the dual roles of these as a
clinical outreach arm of the intensive care unit and in...
Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... measured
tyrosine phosphorylation of the FcR c-chain and the
tyrosine kinase Syk, which is tyrosine phosphorylated and
activated early after GPVI engagement. Phosphorylation of
FcR c-chain was assessed ... was
visualized by incubation with convulxin or an antibody to convulxin,
and indirectly labelled with R-phycoerythin-conjugated anti-rabbit
IgG. Fluorescent GFP is directly visualized...
Báo cáo Y học: The folding of dimeric cytoplasmic malate dehydrogenase Equilibrium and kinetic studies doc
... The minor pathway
(30%) involves an association step leading to the incor-
rectly folding dimers, prior to the very slow D*fiD
folding step.
In this study, we have characterized the folding-as-
sembly ... several in vitro studies established
the above hypothesis [2–6]. These intermediates usually
occur in the kinetic pathway of protein folding; however,
they are often formed so fast that...
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... substrate binding pocket. Few examples exist in which
the ratio between hydrolysis and aminolysis was changed by
changing the catalytic nucleophile. By replacing the active-
site serine in subtilisin ... property of bF24A is its increased esterase/
amidase ratio. In general the enzyme-catalysed hydrolysis of
esters is faster than the hydrolysis of the corresponding
amides due to the...
Báo cáo y học: "The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report" potx
... brain after single oral
administration of fluvoxamine: a positron emission tomography study
using [
11
C]SA4503. Biol Psychiatry 2007, 62:878-883.
26. Bellini L, Gasperini F, Gatti F, Franchini ... SSRIs: human
monoamine transporter binding profile of escitalopram and R-
fluoxetine. Biol Psychiatry 2001, 50:345-50.
29. Goodnick PJ, Goldstein BJ: Selective serotonin reuptake inhibitors...
Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis" potx
... was
diagnosed by histomorphology (in biopsy specimens from
skin and bowel or duodenum), and vasculitis, by histo-
morphology (skin biopsy) and angiogram. All the patients
in this group had joint erosions.
The ... the cytolytic proteins perforin and granzyme B
and are functionally specialized for cytotoxic activity [17].
Perforin was found in CD4
+
CD28
–
peripheral blood lym-
phocytes, a...
Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... glycolytic enzyme G6PI
specifically induces arthritis, with no other symptoms of
organ-specific or systemic autoimmune disease.
Interestingly, although GPI is ubiquitously expressed in the
body, ... autoim-
munity in mice whose T cell repertoire is shaped by a single
antigenic peptide. J Clin Invest 2001, 108:1589-1596.
88. Mathews MB, Bernstein RM: Myositis autoantibody inhibits his-...
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