Báo cáo y học: "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis" pdf

... 4 Research article Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis Pei Jin 1 , Juan Zhang 1 , Percy F Sumariwalla 2 , ... VEGF receptor type 1, VEGF receptor type 2, VEGF receptor type 3, angiopoietin receptor Tie1, Met (receptor for hepatocyte growth factor), colony-stimula...

Ngày tải lên: 09/08/2014, 10:23

... is crucial for the understanding of disease pathogenesis and additionally may provide targets for antigen-specific immune therapy. In this study, we tested 9 self-peptides derived from joint-related ... IFN-γ. Cytokine analysis by lymphocyte intracellular staining and flow cytometry T-cell cultures were performed as described above for 72 hours with 4 × 10 5 cells in 200 μl per...

Ngày tải lên: 09/08/2014, 08:23

... 269) 3143 The origin of these cytosolic oligosaccharides is not known. They could be synthesized in the cytosol by glycosyltransferases which add glucosyl or galactosyl resi- dues to the free ... any of the reactions involved in their biosynthesis represent excellent potential target sites for chemotherapeutic intervention in tuberculosis. However, in mycobacteria there may be as...

Ngày tải lên: 22/02/2014, 07:20

... of the opal codon UGA used for insertion of a selenocysteine in mammal GPXs. The selenocysteine residue is important for the catalytic activity of GPX as replacement of selenocysteine by cysteine ... phospholipid hydroperoxides and a weaker affinity towards t-butyl hydroperoxide, as indicated by their respective apparent K m values. There was no detectable activity with hydrogen pero...

Ngày tải lên: 08/03/2014, 22:20

... follow denaturation (y) prior to the minimization procedure, according to the expression: F U ¼ y À y N Þ= y U À y N Þð6Þ where y N ¼ a 1 + a 2 T and y U ¼ b 1 + b 2 T represents the mean values of the y characteristic ... experimental data, there are as yet no publications in which DSC data have been interpreted through the use of the whole Lumry–Eyring kinetic mode...

Ngày tải lên: 31/03/2014, 15:20

... elegans. They form part of subfamily B (adamalysin subfamily), family M12, in clan MA of the metallopeptidases, as defined in the MEROPS database [5,6] and are structurally and evolutionarily related to ... cleave the growth factor, suggesting that the inhibitory effect is brought about by sequestering VEGF from its cell receptor [41]. By analogy to the thrombospondins, the...

Ngày tải lên: 09/08/2014, 06:23

... subject to take the tablets during the 30 day supplement period. The subjects were asked to return the bottle for a tablet count at the end of the 30 day treatment. To test the efficacy of the vita- min ... through the same 2 day testing procedure described above at the end of the 30 day supplementation period. Laboratory analyses Blood hematology and chemistry analyse...

Ngày tải lên: 09/08/2014, 07:20

... geranylgeraniol reversed the response, confirming a role for inhibition of 3-hydroxy-3- methylglutaryl coenzyme A reductase and geranylgeranylation. Likewise, inhibition by N G -monomethyl-L-arginine ... geranylgeranyl pyro- phosphate and geranylgeraniol, but not farnesyl pyrophosphate or squalene, reverse statin-mediated effects. The role of geranylgeranylation in CD59 expression was t...

Ngày tải lên: 09/08/2014, 08:22

... CRP levels might be a predictor for a high level of adher- ence to therapy. On the other hand, the 1-year level of adher- ence to therapy found in our study closely resembles values found in randomised ... 10 (page number not for citation purposes) other DMARDs, and finally a group of patients treated with TNF blockers as the only antirheumatic therapy (mono- therapy). The group &...

Ngày tải lên: 09/08/2014, 08:23

... system by preferen- tially activating the PI3K/Akt pathway rather than the MEK/ MAPK pathway. Cyclin B 1 and cyclin D 1 Consistent with the increased chondrocyte growth, the expression of the ... significantly but only tran- siently on day 3 of culture, in comparison with the control group [15]. In the current study with a 3D culture system, the number of chondrocytes doubled...

Ngày tải lên: 09/08/2014, 10:23