Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis" doc
Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis" doc
... citation purposes) Vol 10 No 3 Research article The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with ... activity. Proof-of-concept clinical trial in patients with RA A proof-of-concept study to explore safety and tolerability, pharmacokinetic...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo Y học: The human b-globin locus control region A center of attraction potx
... fractionation by mercury a nity chromatography: contrasting distribution of transcrip- tionally active and acetylated histones in nucleosome fractions of wild-type yeast cells and cells expressing a ... D., Francastel, C., Cimora, D.M., Reik, A. , Martin, D.I.K. & Groudine, M. (2000) Nuclear localization and histone acetylation: a pathway for chromatin opening and transcri...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... IIA sPLA 2 s. Ammody- toxins (Atxs) are presynaptic sPLA 2 neurotoxins, ammo- dytins (Atns) I 1 and I 2 are nontoxic sPLA 2 s, and AtnL is a myotoxic but enzymatically inactive sPLA 2 homolog [11–15]. ... binding protein for Atxs was isolated and identified as calmodulin (CaM) [19], indicating that this highly conserved, Ca 2+ -sensing regulatory molecule [20] mayplayaroleinthesPLA 2...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
... ADAMTS5 are protected to a great extent from OA in joint instability models, indicating that this enzyme may play a major role in cartilage catabolism, at least in mouse models of OA [48-50]. Interestingly, ... 2% isoflurane and 0.8 L/minute oxygen. The surgical area was shaved and a three-part preparation was applied containing hibitane soap (Ayerst, Montreal, Quebec, Ca...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "The need for intra aortic balloon pump support following open heart surgery: risk analysis and outcome" pdf
... sec. Routine administra tion of a Cefalos- porin 2 nd generation in combination with vancomycin, through out the IABP support, was maintained. Statistical analysis Collection o f the data is served ... served using the Patients Ana- lysis and Tracking System (PATS) software. Eighty vari- ables were prospectively collected and carefully validated before being analysed. Categorica...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin" ppsx
... 100 and 100 g. This is supported by the fact that heavy chain combinations containing arginine to serine mutations at these positions (IS4 V H iii and IS4 V H iv) displayed approximately 50% weaker ... the general population [4] and a major cause of pregnancy morbidity. APS may occur as a 'freestanding' syndrome (primary APS) [5] or in association with other autoimm...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo Y học: The a1b1 contact of human hemoglobin plays a key role in stabilizing the bound dioxygen Further evidence from the iron valency hybrids potx
... stereochemistry of the iron-dioxygen bond in human HbO 2 by single-crystal X-ray analysis. In the a chain, the distance between N e of His (E7) and the terminal oxygen atom (O-2) is found to be 2.7 A Ê , ... chains in acidic pH range. More speci®cally, the b chain h as acquired this stability by blocking out the proton catalysis performed by the distal histidine residue (Eqn 4...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo y học: "The proliferative human monocyte subpopulation contains osteoclast precursors" ppt
... proliferation and differentiation of osteoclast progenitors. J Clin Invest 1993, 91:257-263. 6. Matsuzaki K, Udagawa N, Takahashi N, Yamaguchi K, Yasuda H, Shima N, Morinaga T, Toyama Y, Yabe Y, Higashio ... Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 1989, 74: 2527-2534. 11. Kawanaka N, Yamamura M, Aita T, Morita Y, Okam...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes" ppt
... Introduction In diarthodial joints, cartilage provides a smooth surface that enables joints to articulate and to withstand compressional and shear stress [1]. Embedded in the cartilage are ... chondro- cytes that respond to biochemical and physical stimuli to maintain this tissue. Cartilage is primarily composed of type II collagen and proteoglycan, which are synthesized by th...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes" ppsx
... signalling [13–15]. RA is characterized by synoviocyte proliferation and infiltration of inflammatory cells, such as lymphocytes and macrophages, into the joint. Local release of pro- inflammatory ... fibroblasts and articular chondrocytes. (a) Human osteoarthritis (OA) synovial fibroblasts (passage 1), (b) de-differentiated human OA articular chondrocytes (passage 2), and (...
Ngày tải lên: 09/08/2014, 01:23