Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... measuring sulphatedglycosaminoglycans (S-GAGs) are available, these assays do not distinguish between synthesis and degradation of the pro-teoglycans [19]. Furthermore, they do not distinguish ... level of IGF-induced collagen II synthesisafter 11 days of cytokine treatment and no IGF-induced colla-gen II synthesis after 17 days of cytokine treatment (Figure2b).Interestingly, under the ... completeanswer but hopefully add a piece of the highly complicatedpuzzle. Most interestingly, aggrecanase- mediated aggrecan degradation was virtually absent at the end of the study period;instead, the...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... lineages.Keywords: as1-casein gene; allelic recombination; geneticpolymorphism; g oat milk.Caseins comprise the main protein fraction of ruminantmilk. They are encoded by four tightly linked ... chain, as compared with the F variant; (c) the deoxycytidyl phosphate residue at position 2 3 in the 9thexon of the A alle le, which is deleted in the F allele, is mutatedtoTintheMallele, giving ... by the F allele. In contrast, in its 3¢ part, beyond exon 8, the haplotype of the M allele is identical with that of the A allele, e xcept at the polymorphicsitelocatedinexon9. In addition, intron...
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Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx
... selectively [20]. In that study a highly specific neutralizing antibody againstIL-8 was administered in several types of acuteinflammatory disease, including lipopolysaccharide/IL-1induced arthritis. ... homeostaticchemokines are involved in maintaining normal leucocytetraffic and cell compartmentalization in lymphoid tissuesunder non-inflammatory conditions [2].Most chemokines play a role in inflammatory ... cytokines and matrix metalloproteinases [3]. Increasedexpression of inflammatory chemokines has been found in many inflammatory disorders, including hepatic disease,multiple sclerosis, transplant...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... Ltd128Arthritis Research & Therapy June 2005 Vol 7 No 3 Hallushers of true disease-modifying therapy in this intractabledisease.Competing interestsFCH is supported by the Arthritis Research ... processesunderlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAHincreases the importance ... importance of diagnosis and monitoring of thiscomplication. Furthermore, since many principles of PAHmanagement translate to the management of RP, this raises the possibility that the generalised...
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Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... pathogenesis of RA.IntroductionSynovial tissue from healthy individuals consists of a singlelayer of synovial cells without infiltration of inflammatory cells. In rheumatoid synovial tissue, lymphocytes ... biology. Role of synovial fibroblasts in the pathogenesis of rheumatoidarthritis. Arthritis Res 2000, 2:361-367.29. Yamanishi Y, Firestein GS: Pathogenesis of rheumatoid arthri-tis: the role of ... Arthritis Res Ther 2004, 6:R120-R128.19. Min SY, Hwang SY, Jung YO, Jeong J, Park SH, Cho CS, Kim HY,Kim WU: Increase of cyclooxygenase-2 expression by inter-leukin 15 in rheumatoid synoviocytes....
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Báo cáo y học: "AIT test has no problem in the detection of anti-ribosomal P" ppsx
... qualitycontrol program run by the Korean Society of LaboratoryMedicine [3]. In 1999 and 2007, reports of antinuclearantibody test using the IT-1 cell line on 208 and 588systemic lupus erythematosus (SLE) ... passed inspection by the Korea Food and Drug Administration in South Korea.Currently, IT-1 is being used under the name of the autoimmune target (AIT) test and it participates in the qualitycontrol ... withcDNA encoding human Ro60. A human macrophage cell linecalled the IT-1 cell line was first introduced at the AmericanCollege of Rheumatology meeting held in Minneapolis in 1994 [2], the same...
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Báo cáo y học: " AIT test has no problem in the detection of anti-ribosomal P – authors’ response" docx
... Despite the clearance of the AIT test by the South Korea Food and Drug Administration, to the best of our knowledge this test is not widely used as ascreening method – neither is it approved by the ... assay, andthen used these sera to determine the positivity and stainingpatterns in the AIT test. This method raises concernsbecause it is generally known that immunodiffusion is arelatively insensitive ... systematic study is mandatory to compare the sensitivityand specificity of the AIT test for the detection of anti-Rib-Pantibodies and other antibody specificities using a variety of contemporary diagnostic...
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Báo cáo y học: "Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled trial" ppt
... for the first time. The outcomes of this trial aretherefore likely t o strongly influence practice guidelinesand clinical care in this area.This trial will be limited by its inability to blind ... apophysis [1-3]. This condition is characterised by pain exp erienced near the lower poster-ior aspect of the calca neus in cl ose proximity to the attachment of the Achilles tendon into the ... anecdotally reported to be the causes of posterior heel pain in calcaneal apophysitsis[15-17]. There is limited evidence to support thishypothesis.5. Obesity: In children obesity has been...
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Báo cáo hóa học: " Research Article Fast Signal Recovery in the Presence of Mutual Coupling Based on New 2-D Direct Data Domain Approach" pdf
... covariance matrix of the interference. Unfortunately, the statistics of the interferencemay fluctuate rapidly over a short distance, limiting the availability of homogeneous secondary data. The resultingerrors ... techniques [13–16]. The approach is to adaptively minimize the interferencepower while maintaining the array gain in the direction of the signal. The sample support problem is eliminated by ... zc y , cxy,0, ,0.(13)Then, the following equation is derived to recover the desiredsignal in the presence of mutual coupling (Proof in the appendix), notwithstanding to compute the inverse...
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Báo cáo Y học: Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration docx
... chaperonin-containing t-complex polypeptide 1 (CCT), also calledTriC, assists in the folding of actin and tubulin in the presence of ATP in vitro and binds newly synthesized actinand tubulin in ... Kubota, H., Hynes, G. & Willison, K. (1995) The chaperonincontaining T-complex polypeptide 1 (TCP-1). Multisubunitmachinery assisting in protein folding and assembly in the eukaryotic cytosol. ... papilla of rats that were water restricted but the protein was increased in the mitochondria of the rat kidneypapilla. We also analysed binding of the protein to the signalsequence of HSP60 using...
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