Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx

... in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis Dongquan Shi 1,2 , Takahiro Nakamura 3 , Masahiro Nakajima 4 , ... oste- oarthritis. Nat Genet 2007, 39:529-533. 6. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida...

Ngày tải lên: 09/08/2014, 10:23

... genetic association in a RA-OA case-control set- ting in a Slovak population. Materials and methods Study participants A total of 520 Slovak individuals (87 males, 433 females) with the diagnosis of ... analysis and drafted the manuscript. JR and SB collected the sample and phenotyped the patients. HGW and SF carried out the HLA typing. CH participated in study c...

Ngày tải lên: 09/08/2014, 14:20

... Russian Federation. The extent of osteoarthritis was determined by analyzing plain hand radiographs. The outcome of a principal component analysis of osteoarthritis scores of a total of 28 joints ... joints of each hand separately, in accordance with the grading system of Kellgren and Lawrence [19]. The OA evalu- ation was based on radiographic changes, such as pre...

Ngày tải lên: 09/08/2014, 06:23

... Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yas- utomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S: Association of STAT4 with ... USA), and association was examined in 308 SLE patients and 306 healthy individuals. Statistical analysis Association of each SNP was analyzed by chi-square test. Because of the...

Ngày tải lên: 09/08/2014, 13:22

... ndividual is willing to participate and is capable of giving informed consent; and (3) individual is a self- reported non-aboriginal Taiwanese, and none of the par- ents and grandparents has aboriginal ... leukocytes using a genomic DNA kit (Qiagen) a ccording to the manufacturer’s instructions. Genotyping was achieved using an assay-on-demand allelic discrimination assay a...

Ngày tải lên: 10/08/2014, 05:21

... records and/ or self-reported questionnaire and each case was validated by cardiac ultrasound and/ or electrocardiographic examinations or by coronary angiography. Table 1: Patient characteristics. ... precipitation of apoB containing lipoproteins with phosphotungstate (Boehringer Mannheim). Apoliprotein AI (Apo AI) and Apo B were measured using the Beckmann Array 360 (Beckm...

Ngày tải lên: 31/10/2012, 17:03

... g. Immunoprecipitation and electrophoresis The radiolabeled supernatant obtained was saved and incubated for 1 h at 4 °C with protein A- Sepharose and centrifuged for 2 min at 10 000 g. The supernatant was incubated ... or CRT and the glycoprotein substrate. At the end of the pulse and at each chase time, cells were lysed and immunoprecipitation was carried out using mAb A1...

Ngày tải lên: 31/03/2014, 08:20

... 1343–1354. 7. Kayagaki, N., Yamaguchi, N., Nakayama, M., Kawasaki, A. , Akiba,H.,Okuma,K.&Yagita,H.(1999)Involvementof TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. ... observations, structural changes of TRAIL induced by acidification reveal that TRAIL might have a potential acid-enhanced cytotoxicity and its intrinsic property be also shared b...

Ngày tải lên: 31/03/2014, 08:20

... triglycerides and C-reactive protein, lower levels of HDL, silent myocardial ischemia, neuropathy, peripheral arterial insufficiency, myocardial infraction, macrovascular disease, abnormal myocardial ... prevent diabetes in managed care and community setting [1, 22, 29]. Health professionals should encourage individuals of all ages to maintain an active life-style that can a...

Ngày tải lên: 08/08/2014, 16:23

... classes of asthma therapy, focusing on a potential genetic clue to medication response. Key words: asthma, genetic polymorphisms O ur understanding of the pathophysiology and treat- ment of asthma ... specific class of asthma therapy. Several recent studies have highlighted phenotypic indicators of response. 1,2 As an example, in a recent study by Szefler and colleague...

Ngày tải lên: 08/08/2014, 21:20