Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
... 1 of 12(page number not for citation purposes)Vol 10 No 3Research articleGenetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: ... potential interactions between the three polymor-phisms of interest and the amount and duration of cigarette Table 4Effect of PTPN22, CTLA-4, and PADI-4 genotypes and the risk of RA in NHS, NHSII and ... (9% in controls and 14% in cases). In analyses involving CTLA-4 and PADI-4, weassessed the risk for RA in dominant, additive, and recessivemodels. Gene-environment and gene-gene interactions We...
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Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... polymorphisms within genes and the analysis of multiple genes within pathways. The effects of polymorphisms are best represented by their haplotypes. Data from multiple polymorphisms within a gene ... common polymorphisms in DNA repair genes are continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including observations ... lesions. These clinical findings are associated with cellular defects, including hypersensitivity to killing and the mutagenic effects of UV and the inability of XP cells to repair UV-induced DNA...
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Báo cáo y học: " Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan" ppt
... Huang YK, Chen YT, Hsueh YM: Urinary8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenicexposure area. Toxicol Appl Pharmacol 2008, 226:14-21.19. Huang YL, Hsueh YM, Huang YK, Yip ... of the data in the study and takeresponsibility for the integrity of the data and the accuracy of the dataanalysis. Study concept and design: CJC, LIH. Acquisition of data: CJC, LIH,WPC, YHC, ... superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern TaiwanLing-I Hsu1, Wu-Ping Chen1, Tse-Yen Yang1, Yu-Hsin Chen1, Wann-Cheng Lo1, Yuan-Hung...
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Báo cáo y học: "Genetic polymorphisms in lung disease: bandwagon or breakthrough?" ppt
... were white and continued to smoke during the 5-year period of the LHS.These subjects were genotyped for polymorphisms in α1-antitrypsin, mEH, vitamin D binding protein, and TNF-α and TNF-β genes. ... pitfall of studying polymorphisms in candidategenes, however attractive, chosen based on a limitedunderstanding of the pathophysiology of disease.Chronic obstructive pulmonary diseaseThat only ... al.quality of association study design. To identify susceptibil-ity loci, association studies involve typing a genetic poly-morphism in unrelated affected individuals and in a group of healthy, ethnically...
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Báo cáo y học: "Logistic Organ Dysfunction Score (LODS): A reliable postoperative risk management score also in cardiac surgical patients" pps
... cardiovascular, and renal dysfunction a nd for the pulmonary, hematologic, and hepatic systems and address both the relative severity among organ sys-tems and the degree of severity within an organ system.The ... (University Hospital of Muenster, Germany) and from the intensive care information system COPRA 5.2(COPRASYSTEM GmbH, Sasbachwalden, Germany),which is interfaced with patient monitors (Philips Intelli-Vue ... [20]. Mortality is strongly related to thenumber and severity, as well as the duration and type of organ dysfunctions, such that the number of failingorgans and the degree of their dysfunction...
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Báo cáo y học: "The Nordic maintenance care program: what are the indications for maintenance care in patients with low back pain" pot
... combined with no previousevents, or 2) a past history of LBP and gradual worsening with treatment. Indications for MC were a good outcomecombined with a previous history of low back pain between ... is being conducted in the Nordic countries trying to illuminate the use of, theindications for, and the efficiency of MC. So far, it hasbeen determ ined, that there is a large degree of consen-sus ... issues for recommending MC are fre-quency of episodes in the past and effect of the treat-ment. Thus, more previous episodes indicate a higher risk of recurrence and therefore a larger need for...
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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... effective in the prevention of NSAID ulcers than low-dose H2RAs [5]. However, the efficacy of PPIs and H2RAs in the primary prevention of clinically relevant endpoints, such asbleeding and perforated ... significantly with regard to thenumber of risk factors for NSAID-associated gastropathy, sug-gesting comparable risk profiles. Similarly, in a post hoc sub-group analysis for those taking either ... Theefficacy of PPIs in the primary prevention of NSAID-associatedgastropathy has so far only been proven for subjective symp-toms and surrogate endpoints, such as dyspepsia and endo-scopic ulcers, and...
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báo cáo hóa học:" Extensor-tendons reconstruction using autogenous palmaris longus tendon grafting for rheumatoid arthritis patients" pot
... (range,32–66) years, the functional requirements of the injuredhands of the patients participating in our study beinghighly " ;in demand" prospectively as regards these individ-uals' working ... diameter, and availability without producing adeformity. This choice of technique for tendon grafting fea-tures the advantage of the source of donor tendon beingreadily accessible in the same forearm.The ... joints. The dynamic splint com-bined with the tendon mobilization program provided thegliding necessary and was easy for the patient to comply with and understand [14]. Some studies relating to "earlyactive"...
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Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson" potx
... exocrino-pathy in the NOD mouse and by reducing one of these regionsconsiderably, Nguyen et al. in a recent issue of Arthritis Research and Therapy propose candidate genes for development of Sjögren’s ... hereditary and environmental factors. Thedisease is characterized by lymphocytic infiltration and inflam-mation in the salivary and lacrimal glands, leading to oral and oculardryness. To understand ... strains. A recombinant inbred line is derived from two strains of mice that are intercrossed for manygenerations in order to obtain mice carrying chromosomalfragments from the parental strains...
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Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study" ppsx
... homeostasis and jointpathology. About 35 were identified with very varied support-ing evidence, including some with a putative protective effect.We looked for evidence of single nucleotide polymorphisms (SNPs) ... recipient of a scholarship of the National Program for the Training of University Professors of the Spanish Ministry of Education. AG was supported by the Instituto de Salud Carlos III (Spain).References1. ... ECM in RA cartilage and bone. In addition, they increase and perpetu-ate joint inflammation through the activation of cytokines,chemokines and other proteases by cleavage of their precur-sors...
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