Báo cáo y học: "Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis" ppt

... the prevalence of cyclic citrullinated peptide antibodies (anti-CCP) in patients with primary Sjögren syndrome (pSS) and its correlation with clinical and laboratory data. Methods We analysed the clinical ... positivity in patients with pSS therefore may be a predictor of future progress to RA or an expression of the inflammatory process of synovial tissue. Introduct...

Ngày tải lên: 09/08/2014, 10:23

... VM: Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 2006, 116:961-973. 8. Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, ... anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther 2004, 6:R142-R150. 6. Spadaro A, Riccieri V, Scrivo R, Alessandri C, Valesini G: Anti- cyclic citrullinated peptid...

Ngày tải lên: 09/08/2014, 14:22

... α-actinin Ab binding, and α-actinin-positive lupus patients were 3.8 times more likely to have renal involvement. Thus, in patients with established SLE, α-actinin Abs may be associated in some ... poten- tial in patients with SLE through cross-reactive α-actinin bind- ing, we analysed the associations between α-actinin binding and clinical and immunological manifestations in...

Ngày tải lên: 09/08/2014, 08:23

... sleep-disrupting cytokines) in favor of sleep-disrupting cytokines. One purpose of this study was to determine whether stratify- ing our patient sample into those with and without comorbid FM would explain ... sleep efficiency, affective symptoms and intensity of fatigue. Neuropsychobiology 2007, 56:40-46. 13. University of Medicine and Dentistry of New Jersey's Pain and Fatigue Stud...

Ngày tải lên: 09/08/2014, 10:23

... needling when combined with acupuncture and the third found a reduction in pain using 1% lidocaine injections when combined with physical therapy. However, the methodological quality of the three trials ... reliability (r = 0.88) and inter-rater reliability (r = 0.75). The original Quality Index is a 27-point checklis t which covers four domains: internal validity, external validity, re...

Ngày tải lên: 10/08/2014, 21:24

... is widely expressed in mesenchymal cells and macrophages and is eas- ily detectable in synovium and fibroblast-like synoviocytes [17- 19]. In vivo, vimentin is usually not in a citrullinated state, ... Carruthers DM, Situnayake D, Gordon C, Buckley CD, Salmon M, et al.: Pre- dictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammator...

Ngày tải lên: 09/08/2014, 08:22

... concentration in a bioassay The biolo gical activity of t he peptide lacking the glycosyl group was d emonstrated by injecting synthetic DUP99B (sDUP99B, s for synthetic; sDUP99B is not glycosylated) into ... results were also obtained by injecting enzymatically de-glycosylated nDUP99B. Because only little material was obtained after de-glycosylation we tested only ovulation. Eighty per c...

Ngày tải lên: 08/03/2014, 22:20

... of rapamycin, a protein which is discussed in more detail in the accompany- ing review by Proud [1]. Insulin has subsequently been shown to decrease eEF2 phosphorylation in primary cell types such ... translo- cation and in poly(U)-directed polyphenylalanine synthesis [26,27], by preventing it from binding to the ribosome [28]. Early data showed that the phosphorylation of eEF2 was...

Ngày tải lên: 23/03/2014, 21:20

... of the QTc interval in adult patients with CTD. The data are summarized in Table 1. Sinus bradycardia Sinus bradycardia has recently been reported as another ECG abnormality found in infants without ... resolution was observed within 15 days [4]. The existence of sinus bradycardia has been reported in two infants with anti-SSA/Ro antibodies [22] and is supported by findings in...

Ngày tải lên: 09/08/2014, 06:22

... recently been realized that the peripheral nervous system has a key role in modulating the severity of RA [2–4]. Synovial tissue is richly innervated with neuropeptide-containing primary afferent ... correlation between the levels of just two neuropeptides, bombesin/gastrin-releasing peptide (BN/GRP) and substance P (SP) with inflammatory cytokines. It is well known that proinflamma...

Ngày tải lên: 09/08/2014, 06:23