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Báo cáo y học: "The need for prognosticators in rheumatoid arthritis Biological and clinical markers: where are we now" potx

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Báo cáo y học: "The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now" potx

... underlyingdisease process. In rheumatology, this variable may be jointReviewThe need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now?Josef S Smolen1,2, ... Pre-analytical and biological variability in circu-lating interleukin 6 in healthy subjects and patients with rheumatoid arthritis. Biomarkers 2008, 13:59-78.54. Weyand CM, Klimiuk PA, Goronzy JJ: Heterogeneity ... Active-Controlled Study of Patients Receiv-ing Infliximab for the Treatment of Rheumatoid Arthritis of EarlyOnset Study Group: Combination of infliximab and methotrex-ate therapy for early rheumatoid arthritis: ...
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Báo cáo y học: "The need for intra aortic balloon pump support following open heart surgery: risk analysis and outcome" pdf

... difficulties in weaning from CPB and also a rather high threshold for intraoperati ve IABPinsertion.Ninety patients had intraaortic balloon inserted intrao-peratively with a mortality of 33.3%. We attempt ... surg ery in patients having sustained mechanical complicationsfollowing myocardial infarction, as well as in patientswith refractory angina [5-7].The hospital and also the 30-day mortality for the ... indications were mainly unstable coronarysyndrome with multivessel disease refractory to maxi-mum medical therapy or symptomatic coronary diseasewith hemodynamic instability. IABP was not used for “prophylactic...
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Báo cáo y học: "Randomized controlled trial design in rheumatoid arthritis: the past decade" docx

... Sandberg G,Crayton H: Demyelination occurring during anti TNF therapy for inflammatory arthritides. Arthritis Rheum 2001, 44:2862-2869.65. Robinson WH, Genovese MC, Moreland LW: Demyelinating ... changes in HAQ-DI (from baseline to 6 and 12 months) were –0.54 in patients who received combinationtherapy for the entire trial compared with –0.30 in thosereceiving combination therapy only during ... opportunistic infections,including tuberculosis or lymphomas, were evident in RCTswith etanercept and infliximab, but larger exposures in real-world use and trials in other clinical indications were...
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Báo cáo y học: "Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production" pot

... recruitment ofinflammatory cells, including monocytes and lymphocytes[1]. It has been proposed that the first cells to infiltrate syn-ovial tissue are T lymphocytes, suggesting that they havean ... water for 1 minute, and incubated in PBS for 5minutes, followed by the addition of 3,3'-diaminobenzidine(Sigma) for 12 minutes. The chromogenic reaction wasstopped by immersion in water. ... cells in these areas [15].Conclusion In conclusion, the localization of apoA-I in inflamed syn-ovium suggests that it can locally inhibit the production ofproinflammatory cytokines by monocyte–macrophagesupon...
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Báo cáo y học: "CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes" pptx

... media were collected and analyzed for matrix metalloproteinase (MMP) activity by gelatin zymography. (a) Secretion and activation of MMPs in FLS from rheumatoid arthritis (RA) and osteoarthritis ... were analyzed by agarose gelelectrophoresis using 1% gel, followed by ethidium bromidestaining.Gelatin zymographyGelatin zymography was performed for detection of MMPactivity in conditioned ... work is needed to test this supposition. In our previous study, we found that CD147 was expressedpredominantly on the MLS and FLS in the lining and sublininglayers of RA synovium, and macrophages...
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Báo cáo y học: "NGR1 single nucleotide polymorphisms in rheumatoid arthritis" pdf

... only extremelyrarely present in the Japanese population [8]. Our data are in line with these observations and together implicate that asso-ciation findings should be carefully analyzed in different ... 40 nor cytosine at position 1,400)were detected in any of the individuals tested. This was sur-prising because both positions were highly polymorphic in theoriginal publications. In those publications, ... heterozygosity atposition 40 (V14M) was detected in four individuals (4.4%) in a small cohort of 91 healthy controls and even in 15 out of 96(15.6%) lupus patients [7], and heterozygosity at...
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Báo cáo y học: " Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides" potx

... (ever/never), body massindex at age 20 years and 10 years before interview, level ofphysical activity at work and during leisure time 10 yearsbefore interview, pets in childhood and in adulthood, ... obese 10 years before interview was marginallyassociated with increased RA risk. Furthermore, having aphysically demanding job 10 years before interview was asso-ciated with significantly increased ... chance findingappears unlikely given the highly significant trend with increas-ing body mass index and its specificity to anti-CCP-negativeRA. Theoretically, however, although we included only patientswho...
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Báo cáo y học: "Remission by composite scores in rheumatoid arthritis: are ankles and feet important" pptx

... involved in the disease. Joints are usually assessed for tenderness and swelling, and joint counts are predictive of radiographicchanges as well as of long-term morbidity and mortality in RA28-JC ... disease activ-ity assessment in RA. In this study, we showed that theassessment of joint activity in the feet, beyond assessment ofjoint activity by the 28-joint count, does not convey significantadded ... that while providing useful and important clinical information, the inclusion of ankles and feetonly rarely influences the definition of overall disease activitystatus, especially the presence...
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Báo cáo y học: "Diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital X-ray radiogrammetry" ppsx

... H, Hyldstrup L; the TIRA group: Bone loss in unclassified polyarthritis and early rheumatoid arthritis isbetter detected by digital X-ray radiogrammetry than dualenergy X-ray absorptiometry: ... Emery P: Generalizedbone loss in patients with early rheumatoid arthritis. Lancet1994, 344:23-27.4. Deodhar AA, Brabyn J, Pande I, Scott DL, Woolf AD: Hand bonedensitometry in rheumatoid arthritis, ... course ofprogression during the early years of disease, and therefore ithas been recommended that conventional imaging of thehands and feet be done every year during the initial periodafter RA...
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Báo cáo y học: "Detection of bone erosions in rheumatoid arthritis wrist joints with magnetic resonance imaging, computed tomography and radiography" ppt

... ofvalue for detecting and monitoring bone erosions in RA. Thesensitivity to change is not yet established, however, and CTis disfavored by using ionising radiation and by the inability tovisualise ... erosions difficult, and nutri-tive foramina may also resemble erosions [28]. This may, atleast partly, explain the lower sensitivity and accuracy in thiswrist joint study compared with previous ... not for citation purposes)The even higher agreement (87% vs 77%) between CT and MRI in a study of nine RA wrist joints by Perry and colleagues[12] may partly be explained by more advanced joint...
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