Báo cáo y học: "Action of fibroblast growth factor-2 on the intervertebral disc" docx

... accumula- tion in the CM is therefore, in part, the result of an inhibition of proteoglycan synthesis. FGF2 antagonizes BMP7-mediated stimulation of proteoglycan accumulation Having previously shown ... chemical pathways utilized by FGF2 to antagonize the activity of BMP7 were analyzed to gain a better understanding of the complex interplay of growth factors, cytokines,...

Ngày tải lên: 09/08/2014, 10:23

... caused degradation of the ECM. The combination of FGF8 and IL-1α accelerated the degradation of the ECM. Anti-FGF8 antibody suppressed the effects of FGF8 on the cells. Conclusion FGF8 is produced by injured ... chondrocytes. These studies suggest that the injury of synovia induces the expression of FGF8 in the joint, and this may promote degradation of carti...

Ngày tải lên: 09/08/2014, 10:23

... Fasano 3 1 Department of Chemistry ‘IFM’, University of Torino, Italy; 2 Department of Biology, University ‘Roma Tre’, Rome, Italy; 3 Department of Structural and Functional Biology, University of Insubria, Italy Haem ... affecting the coordination number or the spin state of the haem-iron, and the quenching of the 1 H-NMR relaxivity. Values of K d for ibuprofen and...

Ngày tải lên: 31/03/2014, 23:20

... raised by increasing the activity of adenylate cyclase or by decreasing the activity of phosphodi- esterases. In the light of the observation that a physiologi- cal activator of adenylate cyclase, ... by monocytes. Spontaneous production of IL-10 and TNF-α by monocytes could not be detected; cytokine production was induced, however, by addition of LPS (control samples). VI...

Ngày tải lên: 09/08/2014, 01:23

... Access Frontiers of Oncology: Biobanking Resources for the 21 st Century Jill Barnholtz-Sloan and Mark R Chance * The progress of translational research and enhancing the prospects for personalized ... biologic data is at the highest level of evolution. Standardization of biospe- cimen collection and consent processes, processing and annotation of biospecimens and prioritiza...

Ngày tải lên: 10/08/2014, 09:22

... coronary angiography was performed following the administration of intracoronary glyceryl nitrate. At least six standardized projections of the left coronary artery and two of the right coronary ... and the risk of restenosis after percutaneous coronary intervention. Limitations of the study There are several limitations of the study: first of all, we did not carry o...

Ngày tải lên: 12/08/2014, 15:21

... evaluation of the haemodynamic differences observed in the patients studied. Concerning the data recorded by the thermodilution right ventricular ejection fraction pulmonary artery catheter, the absence ... Laboratories). The first profile measured the heart rate, the systolic systemic pressure, the diastolic systemic pressure, the mean systemic pressure, the mean pulm...

Ngày tải lên: 12/08/2014, 19:22

... injury [1]. Spinal stabil- ity is theorized by Panjabi [2] to be maintained by the interaction of three systems: the active system, the passive system and the neural control system. The active system ... greater the tension in the guy wires and the greater the number of guy wires, the greater the stability and load supported by the mast. Adequate muscular activatio...

Ngày tải lên: 13/08/2014, 13:22

... complexity of the regulatory mechanisms in eukaryotes the computational prediction of functional regulatory sites remains a difficult task, and the spatial organization of the sites is the prob- lem of ... construction on the search of only these features. (An increase of the number of "normal" pairs in the search will not dramatically improve the s...

Ngày tải lên: 13/08/2014, 22:22

... evaluated the impact on the outcome of a monotherapy or a com- bined therapy in patients with PA-VAP. They s howed that the initial use of a combination therapy significantly reduced the likelihood of ... inappropriate antimicrobial therapy on the prognosis might be due to the high severity of patients at VAP onset (SOFA at 6 in median in the present study). As any d...

Ngày tải lên: 14/08/2014, 08:21