Báo cáo y học: " Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation" ppt
Báo cáo y học: " Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation" ppt
... significantly diminished in PAR -4- deficient mice and underlines the important role of fibrin in inflammation. These may be mediated by fibrin- induced macrophage secretion of proinflammatory cytokines such ... two Figure 4 Analysis of soluble tissue factor-induced inflammation in protease activated receptor- deficient miceAnalysis of soluble tissue factor-induced...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
... the role of cytokines in RP, either in patients or in the corresponding animal models. In the CIA model, several cytokines have been shown to play major roles in the inflammatory process, anti-inflammatory mediators ... cartilage. Staining with hematoxylin and erythrosine. Original magnification ×200. Figure 3 Titers of antibodies to matrilin-1 in mice immunized with matril...
Ngày tải lên: 09/08/2014, 01:24
Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... neutrophils into the synovial lining and fluid and the periarticular spaces. These infiltrating cells produce abundant cytokines, dominated mainly by the inflammatory type of cytokines such as ... peritonitis [44 ], suggesting a more general mechanism of these receptors in inflammatory diseases. Maintaining autoantibody titers through FcRn-mediated recycling One of the most striking c...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo khoa học: Essential role of the C-terminus in Melanocarpus albomyces laccase for enzyme production, catalytic properties and structure pdf
... structure Distances (A ˚ )ABABABAB T3–T3¢ 5.1 5.2 4. 7 4. 7 4. 9 4. 8 4. 7 4. 7 T3–T2 4. 1 4. 4 3.9 4. 0 4. 1 4. 1 4. 0 4. 0 T3¢–T2 4. 0 4. 4 4. 0 3.9 3.9 4. 1 4. 0 4. 0 T2–Cl 3.0 – 2.5 2.6 2.9 2.8 2.5 2.5 T3–O1 2.6 ... Sc(L559A) K m (lM) 40 0 900 11 16 37 31 k cat (min )1 ) 1686 3 94 612 545 241 0 1263 k cat ⁄ K m (lM )1 Æmin )1 ) 4. 2 0 .44 48 34. 3 66 41 .3 K i (lM)...
Ngày tải lên: 16/03/2014, 00:20
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... negligibly participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro 74 jointly contribute 45 % of the total unitary free energy of binding of cystatin ... B. Keywords: cathepsins; cystatin; cysteine proteases; papain; second binding loop. Cystatins are effective protein inhibitors of cysteine pro- teases of the papain...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... to efficiently deacylate the phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, a twofold and fourfold increased V s /V h ratiocomparedtothe wild-type (Table 4) . ... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the bindi...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. J. Am. Chem Soc. 120, 841 0– 841 6. 15. Zhou, Z.S., ... to ligation of the thiol group of coenzyme M. Mutations in His237 or Cys239, which are proposed to be involved in ligating zinc, resulted in an over 90% loss in enz...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this ... The effect of cysteine mutations on the activity of recombinant deacetoxycephalosporin C synthase from S. clavuligerus. Biochem. Biophys. Res. Commun. 267, 44 5 44 8. 18. Baldwin, J...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
... Russia; 3 Department of Veterinary Pathology, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Edinburgh, UK; 4 Respiratory Medicine Unit, Department of Medicine, University of Cambridge School of ... Walker 5 1 Department of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Edinburgh, UK; 2 Shemyakin- Ovchinnikov Institute of...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... delivery. The frequency of developing atopic dermatitis in the offspring was significantly reduced by 2, 4, and 7 years [26-28], by 50%, 44 %, and 36% respectively. Similar studies have yielded ... development of the immune system in early childhood. Eur J Nutr 2002, 41 (Suppi 1):I32-7. 18. Penders J, et al.: Molecular finger printing of the intestinal microbiota of infants in...
Ngày tải lên: 08/08/2014, 21:20