Báo cáo y học: " Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes" doc

... article Extracellular heat shock protein 70 inhibits tumour necrosis factor-α induced proinflammatory mediator production in fibroblast-like synoviocytes Xinjing Luo 1,2 , Xiaoxia Zuo 3 , Yaou Zhou 3 , Bing Zhang 1 , ... self-HSP70 may Figure 6 HSP70 inhibits translocation of NF-κB and degradation of IκBαHSP70 inhibits translocation of NF-κB and degradation o...

Ngày tải lên: 09/08/2014, 10:23

... ER-lumi- nal heat shock protein (Hsp) 70, IgG heavy chain-binding protein (BiP), at least one of which also involves the second ER-luminal Hsp70, glucose-reg- ulated protein (Grp) 170. In addition, ... organization of the various proteins is indicated (PB, peptide-binding domain; GF, glycine ⁄ phenylalanine-rich region; Cys, cysteine-rich region; TRX, thioredoxin-like domains). T...

Ngày tải lên: 30/03/2014, 03:20

... Evolutionary diversity of vertebrate small heat shock proteins. J Mol Evol 59 , 792–805. 15 Mounier N & Arrigo A-P (2002) Actin cytoskeleton and small heat shock proteins: how do they interact? ... accompanies phosphorylation- induced changes in the oligomeric structure of heat shock protein 27. Mol Cell Biol 15, 505–516. 25 Bryantsev AL, Loktionova SA, Ilyinskaya OP, Ta...

Ngày tải lên: 16/03/2014, 06:20

... retention of TRAF4. Interestingly, it has been recently shown that the oncogenic serine–threonine kinase Pim-1 induces translocation of the TRAF4-interact- ing protein- sorting Nexin 6–TRAF4–associated ... lysates containing cytoplasmic (C) and nuclear proteins (N) were analyzed by Western blotting. TRAF4 was detected using an affinity-purified polyclonal anti- (TRAF4) goat Ig recognizing a car...

Ngày tải lên: 21/02/2014, 15:20

... cytokines [17,18]. In this study, we analysed whether apoptotic keratino- cytes in patients with SLE, as induced by a single dose of UVB, are cleared with delay and/or in an inflammatory way that results in ... specifically induces inflammation in LE lesions. Binding of autoantibodies to apoptotic keratinocytes in the skin and subsequent pro-inflammatory clearance by macrophages...

Ngày tải lên: 09/08/2014, 08:22

... PUMA -induced apoptosis is therefore independent of p53 in FLS. These data Figure 4 Apoptosis induced by PUMA in p53 +/+ and p53 -/- murine fibroblast-like synoviocytes (FLS)Apoptosis induced by ... on induc- ing apoptosis in the synovium, especially the intimal lining [2,4]. This region is populated by macrophage-like and fibrob- last-like synoviocytes and is a primary source...

Ngày tải lên: 09/08/2014, 08:22

... RJ: Changes in cerebrospinal fluid levels of proinflammatory cytokines in CRPS. Pain 2005, 116:213-19. 3. Ludwig J, Baron R: Complex regional pain syndrome: an inflammatory pain condition? ... stored in the fixative solution (10% formalin) and cut into 4 μm thickness size. Staining was done by using hematoxylin and eosin as described by Yukari et al., [31]. Nerve sections were anal...

Ngày tải lên: 10/08/2014, 10:20

... strong immunostaining in the nucleus. Pretreatment with BAY 11 -708 2 inhibited hypoxia ⁄ SD -induced NF-jBp65 translocation, with substantial levels of NF-jBp65 staining remaining in the cytoplasm of ... signal-regulated kinase pathway The extracellular signal-regulated kinase 1 ⁄ 2 (ERK1 ⁄ 2) and p38 mitogen-activated protein kinase (p38) signal- ling pathways play important roles...

Ngày tải lên: 18/02/2014, 04:20

... signaling pathways which stimulate cytokine and chemokine production by microglia [9-11]. NADPH oxi- dase activity has also been linked to HIV Tat -induced cytokine and chemokine production by microglia, ... infection induces intracellular ROS generation by murine microglia To determine the role of redox responses in virus- induced cytokine and chemokine production, we first examine...

Ngày tải lên: 19/06/2014, 22:20

... novel protein complex mediating parvovirus -induced cytotox- icity. J Virol 2006;80(10):4729-39. 53. Nuesch JP, Rommelaere J. A viral adaptor protein modulating casein kinase II activity induces ... pathway in NS1 -induced apoptosis was examined in GFP/NS1-transfected cells by treat- ing the cells with caffeine. Incubation of GFP/NS1-transfected cells with caffeine inhibited a...

Ngày tải lên: 25/10/2012, 11:18