Báo cáo y học: "Gout in the spotlight" ppsx

... come about only with a clearer understanding of the underlying mechanisms. Competing interests The author declares that they have no competing interests. References 1. Pessler F, Mayer C, Jung ... practice, particularly in the elderly population with multiple co-morbidities. Any new therapies that target the new inflammatory processes set off by MSU crystals will potentially have a...

Ngày tải lên: 09/08/2014, 10:23

... the inflammatory effects of MSU [24], suggesting that the pro-inflammatory effects of IL-1 require mesenchymal cells such as the endothelium to respond to this cytokine. Together, these findings ... is the normal product of purine metabolism in humans and in the plasma exists mainly in the form of urate. In the more acidic environment of the renal tubule, however, it i...

Ngày tải lên: 09/08/2014, 13:22

... not maintained by the neighbouring tyrosine, while the W121F /Y1 22F mutant activity may be viewed as a commitment of the tyrosine residue to support the (somewhat higher) residual activity of the ... not address the question whether any other (aromatic) side chains in this or the neighbouring position might be able to support electron transfer to the Cu A site, thereby func...

Ngày tải lên: 22/02/2014, 07:20

... a similar apparent binding affinity (K d ) for the large lipid particles, are notably distinct in their maximum binding capacities (Table 2). In particular, the binding footprint for the apoE4 isoform, ... obtained by analytical ultracentrifugation using the direct binding assay as des- cribed in Experimental procedures. Inset: Linearized plot of the binding data for apoE(263–2...

Ngày tải lên: 08/03/2014, 09:20

... state of the art in endoscopic sinus surgery includes many recent innovations. Prob- ably the most fundamental change in sinus surgery has been the adaptation of rigid endoscopes for use in the nose. ... con- trol recurrent inflammatory disease. Further, in some instances, surgical cleaning of polyps and obstructing mucosal hypertrophy can result in long-term control or “cur...

Ngày tải lên: 08/08/2014, 20:23

... modulating the immune function [42,43] might affect the initial steps in the inflammatory cascade and thus influence alterations in the functional activity of the major mediator of the inflammatory ... protein C3 is the initial point of the alternative pathway,and,atthesametime,aconvergepointofall three complement activation pathways, i.e. starting point for the terminal...

Ngày tải lên: 08/08/2014, 21:20

... that pain fibers can be identified in the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which ... When the joint is young and healthy, complex and overlapping systems protect it from injury. These include the muscles across the joint which contract in a smo...

Ngày tải lên: 09/08/2014, 01:22

... ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce a plethora of inflammatory products, including degradative enzymes, ... most if not all of the total phenotypic expression of RA, including joint destruction. The fact that CRP is induced by the proinflam- matory cytokine interleukin-6 (IL-6) and th...

Ngày tải lên: 09/08/2014, 01:22

... of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [21], the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Metrology Index (BASMI) (all ... or more of the following criteria: fulfilling the clinical symptom of inflammatory back pain, being positive for HLA-B27, or showing evidence of sacroiliitis by imaging [11]. Analyzing...

Ngày tải lên: 09/08/2014, 01:22

... generically as a pyrin domain (PYD) in other proteins that have homology with pyrin’s N-terminal sequence [12]. Members of the death domain superfamily are involved in the assembly and activation ... exceptionally rare autosomal dominant disease is caused by mutations in the proline serine threonine phosphatase- interacting protein-1 (PTSTPIP) gene encoding a protein also known as...

Ngày tải lên: 09/08/2014, 01:22