Báo cáo y học: "Exogenous tumour necrosis factor α induces suppression of autoimmune arthritis" ppsx

... Moudgil 1,2 1 Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA. 2 Division of Rheumatology, Department of Medicine, University of Maryland School of Medicine, ... 4 Tumour necrosis factor (TNF )α treatment of Lewis (LEW) rats neither increased the release of soluble TNF receptor I (sTNFR-I) nor induced the genera...

Ngày tải lên: 09/08/2014, 10:23

... individualsPattern of plasma tumour necrosis factor (TNF) bioactivity in rheuma- toid arthritis (RA) patients and healthy individuals. Using the ability of TNF -α to stimulate RA synoviocytes, TNF -α (5 ng/ml) ... charac- teristics of the patients are summarized in Table 1. Bioassay for circulating TNF -α bioactivity A functional assay for TNF -α activity was designed using t...

Ngày tải lên: 09/08/2014, 06:22

... D, de la Cruz J, Pablos JL: Clinical significance of synovial lymphoid neogenesis and its reversal after anti- tumour necrosis factor α therapy in rheumatoid arthritis. Ann Rheum Dis 2009, 68:751-756. 11. ... although LTα may play a predominant role in promoting the formation of tertiary lymphoid tissue at sites of chronic inflammation [8,9]. Whether differences between the two...

Ngày tải lên: 09/08/2014, 14:22

... birth, they develop splenomegaly and lymphadenopathy associated with increased generation of T-helper-1 cells and hyper- gammaglobulinaemia. By 8 months of age gp130 F759/F759 mice develop a symmetrical ... investigation of lymphocyte development uncovered a reduced frequency of CD4 + CD8 + double positive thymocytes in the mutant mice, associated with increased CD4 + or CD8 + single...

Ngày tải lên: 09/08/2014, 01:23

... family of proteolytic enzymes responsible for matrix degradation. Macrophage migration inhibitory factor (MIF) is a cytokine that induces the production of a large number of proinflammatory molecules ... cel- lular components of inflamed synovium consist of inflammatory cells, predominantly macrophages, T lymphocytes, and an overgrowth of synovial fibroblasts. RA synovial fibr...

Ngày tải lên: 09/08/2014, 08:22

... arachnoid cyst; syringomyelia. Introduction The commonest type of arachnoid cyst that causes compression of the spinal cord and develop- ment of syringomyelia is the Chiari malformation type I ... follow-up of Chiari-related syringomyelia in adults: analysis of 157 surgi- cally treated cases. Neurosurgery. 2009;64:308-15. 33. Wetjen NM, Heiss JD, Oldfield EH. Time course of...

Ngày tải lên: 25/10/2012, 11:00

... majority of patients that require rapid tranquilisation have some form of seri- ous psychosis and may also have physical problems such as biochemical disturbances and dehydration [3,4] For many years ... http://www.annals-general-psychiatry.com/content/6/1/11 Page 5 of 5 (page number not for citation purposes) Competing interests Chris Bushe is an employee of Eli-Lilly UK. Dr M Taylor...

Ngày tải lên: 08/08/2014, 21:20

... effect of multiple types of stressors on the physiology and symptomatology of patients with RA. Collectively, laboratory research has docu- mented a maladaptively pro-inflammatory response to stress among ... assay has a lower limit of detec- tion of 0.16 pg/mL, a sensitivity of 0.04 pg/mL, and an intra- assay coefficient of variation of less than 5%. Similarly, an enzyme-link...

Ngày tải lên: 09/08/2014, 14:20

... fibroblast-like synoviocytes of patients with RA [45]. Our results agree with findings of the absence of a major role of TNF -α in the patho- genesis of pSS, as illustrated by the lack of efficacy of TNF -α blockers ... Gentz R, Parmelee D, et al.: BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999, 285:260-263. 10. Mukhopadhyay A,...

Ngày tải lên: 09/08/2014, 07:20

... 16:4604-4613. 12. Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y: A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 α regulates the VEGF expression and ... Histological confirmation of the arthritic pathology was performed on haematoxylin and eosin stained sections. Immunohistochemistry for HIF-1 α and HIF-2 α expression The H...

Ngày tải lên: 09/08/2014, 01:21