Báo cáo y học: "Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs" pdf

... or induce these inflammatory mediators. Accordingly, the present study examines the interplay between mechano-sensitive and cytokine-sensitive pathways, and determines the effects of IL-1β and ... or dynamic compression. In addition to the regulation of iNOS and COX-2 expression by dynamic compression, co- stimulation with the inhibitor was important in restoring the cytokin...

Ngày tải lên: 09/08/2014, 10:23

... interaction between NS1 and PARP. Since PARP is active at the site of single strand DNA breaks, and single-strand nicking is a known activity of NS1 protein, it is likely that NS1 is nicking ... helix-distorting damage repair pathways, mediated by ATM or ATR, are ne- cessary for optimal induction of apoptosis induced by NS1 expression, since inhibition of these pathways significa...

Ngày tải lên: 25/10/2012, 11:18

... factors in non-Kuna living in the Panamanian mainland. Obtaining this information should have a high priority. There is very probably less exposure to pollutants in the water and in the air in ... to the mainland, especially for those inhabitants that live in the city. Tobacco use by Kuna is limited both in the indigenous island site and the mainland. Other variables...

Ngày tải lên: 31/10/2012, 15:12

... (20). In contrast, Kurita et al. reported on an increased mechanical dyssynchrony during pacing induced tachycardia in patients with normal QRS duration (21). A remarkable increase in intra-LV ... biventricular pacing typically improves the time course of cardiac contraction at rest and during exer- cise by reducing LV dyssynchrony and thereby liber- ating a further segment o...

Ngày tải lên: 05/11/2012, 11:32

... recombinant proteins leading to a compromised mitochondrial integrity rather then to an intrinsic property of the proteins. T his could e xplain the lack of r egulation by free fatty acids and purine ... folding and thus does not represent a physiologically relevant function of the protein. These findings imply that, r esults and phenotypes obtained after overexpression of UCP3, and po...

Ngày tải lên: 21/02/2014, 15:20

... acid; BHA, butylhydroxyl anisol; ERK, extracellular signal-regulated kinase; IFN, interferon-c;iNOS,indu- cible nitric oxide synthase; JNK, c-Jun NH 2 -terminal kinase; LPS, lipopolysaccharide; ... S L., Lin, P L. & Lin, C N. (1999) Stimulation of respiratory burst by cyclocommunin in rat neutrophils is associated with the increase in cellular Ca 2+ and protein kinase C activit...

Ngày tải lên: 22/02/2014, 04:20

... corresponding to the microscopic findings in hematoxylin and eosin staining. In addition, leukocyte infiltration into the synovial fluid of the inflamed knee joints following rTRAIL treatment was reduced ... examined by measuring serum alanine aminotransferase (ALT) levels in rabbits prior to injection of IL-1β expressing cells (day 0), 3 days post-injection of IL-1β expressing c...

Ngày tải lên: 09/08/2014, 07:20

... transfer by reinnervating most functionally impor- tant nerves using intact neighboring nerves has become widely accepted since it was reported by Seddon in 1963 [23]. Since then variety of donor ... contributions HR and SRS were the main operating surgeons and designed the study, PB and SRJ performed data collection and analysis of the results, HR and PB were involved in sequen...

Ngày tải lên: 10/08/2014, 10:20

... Ligation of RNA-containing duplexes by Vaccinia DNA ligase. Biochemistry 36, 9073–9079. 79. Sriskanda, V. & Shuman, S. (1998) Specificity and fidelity of strand joining by Chlorella virus DNA ... Lee, J .Y. , Kim, H.K., Chang, C., Eom, S.H., Hwang, K .Y. & Cho, Y. , Yu, Y. G., Ryu, S.E., Kwon, S.T. & Suh, S.W. (2000) Crystallization and preliminary X-ray crystallographic analy...

Ngày tải lên: 21/02/2014, 01:21

... not known and could be assessed only by comparing dynamic MRI and synovial membrane histology in the same joints. Other vessel characteristics of PsA synovial membrane that could play a role in contrast ... correlation between clinical and laboratory indexes of RA inflammation and dynamic MRI. However, the inclusion of severely active arthritis only – with exclusion of patients i...

Ngày tải lên: 09/08/2014, 06:22