Báo cáo y học: " Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets" pps

... initially present in the small joints of the feet, and appear in the small joints of the hands at a later point in the disease course [6]. Also, rheumatoid nodules are very rare in the early phases of RA, ... evaluated. Review Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets Anne...

Ngày tải lên: 09/08/2014, 10:23

... technology has been, theoretically, to increase the safety and com- pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of health ... con- trol recurrent inflammatory disease. Further, in some instances, surgical cleaning of polyps and obstructing mucosal hypertrophy can result in long-term control o...

Ngày tải lên: 08/08/2014, 20:23

... lamivudine and adefovir dipivoxil. The immunomodulators act by promoting cytotoxic T cell activity for lysis of infected hepatocytes and by stimulating cytokine production for control of viral ... enhance its efficacy. A more rational form of therapy should entail the use of HBV-specific immune therapy either in the form of therapeutic vaccine or DNA vaccine. Hopefully, i...

Ngày tải lên: 02/11/2012, 11:17

... a ‘baseline’ indicator of HBV infectivity, the measurement of viral load is an indispensable means for monitoring and confirming resistance to lamivudine therapy. Indeed, resistance to antivirals ... it is the appearance of serum markers of HBV infection that establishes the diagnosis of the disease. Of these, HBsAg is considered to be the sentinel marker for th...

Ngày tải lên: 03/11/2012, 09:41

... procollagen prolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX) and lysyl hydroxylases (procollagen lysyl hydroxylase and procollagen lysyl hydroxylase 2). Similar links between hypoxia and ... and oxygen levels were similar to those in healthy individuals. We quantified oxygen levels in the skin of SSc patients by applying an oxygen partial pressure (P O 2 ) histography meth...

Ngày tải lên: 09/08/2014, 01:22

... but they may relate to more defined arthritis conditions than the human disease. Interestingly, the pristane-induced arthritis model used to identify the polymorphism in Ncf1 in rats is B-cell inde- pendent. ... most likely that the shift affects the three-dimensional structure of the protein, impairing the binding capabilities to the other pro- teins in th...

Ngày tải lên: 09/08/2014, 10:21

... contributors to the pathogenesis of RA. MCs may be considered the immunological sentinel of the syn- ovium, acting immediately in the event of joint trauma by liber- ating an array of proinflammatory ... mediators. However, MCs also appear to perpetuate the chronic process by their marked increased accumulation in the synovial lining of the inflamed joint and t...

Ngày tải lên: 09/08/2014, 14:22

... Research & Therapy, in which they describe cytokine patterns of inflamed joints from patients with Behçet’s disease (BD). The authors show that neutrophils and T lymphocytes are involved in a Th1-skewed inflammatory ... terminated while TNF blockage was continued. Cytokines were evaluated in the resected colon by analyzing mRNA expression levels of cytokine genes as previo...

Ngày tải lên: 09/08/2014, 14:22

... primary care physician was initially con- cerned about cervical root trauma given his history of degenerative disc disease and the nature of the injury, but an MRI and CT myelogram of the cervical ... patient's surgery. JY and GC helped to conceive of the study and participated in the editing process. MB performed the electrodiagnostic studies in the neurolo...

Ngày tải lên: 10/08/2014, 10:20

... time scales in the analysis of these (k +l)-dimensional models by split- ting the system into the k-dimensional fast subsystem obtained in the singular limit ε → 0of( 1) and known as the layer problem, ... Hopf bifurcation in the full system will persist in the singular limit as a Hopf bifurcation in the layer problem. It might be tempting to proceed by determi...

Ngày tải lên: 20/06/2014, 23:20