Báo cáo y học: " Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets" pps

... initiallypresent in the small joints of the feet, and appear in the smalljoints of the hands at a later point in the disease course [6].Also, rheumatoid nodules are very rare in the early phases of RA, ... evaluated.Review Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsetsAnnette HM van der Helm-van Mil and Tom WJ HuizingaDepartment of Rheumatology, Leiden ... from genetics to clinicalpractice. In contrast to the recent advances in the field of susceptibility to RA, genetic variants affecting the severity of the disease course in RA are scarcely explored....

Báo cáo y học: Advances in the Surgical Management of Chronic Rhinosinusitis" pot

... technology has been,theoretically, to increase the safety and com-pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of health ... con-trol recurrent inflammatory disease. Further, in some instances, surgical cleaning of polyps andobstructing mucosal hypertrophy can result in long-term control or “cure” of the sinus disease from ... diffuse sinonasalpolyposis with polyps projecting into or com-pletely occluding the nasal airway (CRS withpolyposis). However, the prognostic implica-tions of such distinctions remain to be...

Báo cáo y học: "Advances in immunomodulating therapy of HBV infection"

... lamivudine and adefovir dipivoxil. The immunomodulators act by promoting cytotoxic T cell activity for lysis of infected hepatocytes and by stimulating cytokine production for control of viral ... enhance its efficacy. A more rational form of therapy should entail the use of HBV-specific immune therapy either in the form of therapeutic vaccine or DNA vaccine. Hopefully, in the future, more ... two-thirds. The cellular immune response contributes to the elimination of the virus but is also responsible for liver damage caused by the lytic activity of HBV-specific cytotoxic T lymphocytes (CTL)...

Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"

... a ‘baseline’ indicator of HBV infectivity, the measurement of viral load is an indispensable means for monitoring and confirming resistance to lamivudine therapy. Indeed, resistance to antivirals ... it is the appearance of serum markers of HBV infection that establishes the diagnosis of the disease. Of these, HBsAg is considered to be the sentinel marker for the confirmation of acute infection. ... Generally, some 8 to 16 weeks will usually have elapsed from exposure to the virus until the appearance of telltale symptoms. HBsAg is also the key marker in determining whether hepatitis B infection...

Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt

... procollagenprolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX)and lysyl hydroxylases (procollagen lysyl hydroxylase andprocollagen lysyl hydroxylase 2). Similar links betweenhypoxia and ... andoxygen levels were similar to those in healthy individuals.We quantified oxygen levels in the skin of SSc patients byapplying an oxygen partial pressure (PO2) histographymethod, involving ... prolyl hydroxylase domainactivity in chronic hypoxiaInterestingly, PHD2 and PHD3 are induced by hypoxia in aHIF-1α-dependent manner, thereby creating a negativefeedback loop of HIF-1α signalling...

Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc

... but theymay relate to more defined arthritis conditions than the human disease. Interestingly, the pristane-induced arthritis modelused to identify the polymorphism in Ncf1 in rats is B-cell inde-pendent. ... mostlikely that the shift affects the three-dimensional structure of the protein, impairing the binding capabilities to the other pro-teins in the complex. The activation of the NOX complex is ini-tiated ... cells. In the rat a clear difference in the capacity to produce oxidativeburst is the result of a single SNP in Ncf1, resulting in the shiftfrom threonine to the disease- promoting methionine at...

Báo cáo y học: " Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study" pdf

... contributors to the pathogenesis of RA. MCsmay be considered the immunological sentinel of the syn-ovium, acting immediately in the event of joint trauma by liber-ating an array of proinflammatory ... mediators. However, MCsalso appear to perpetuate the chronic process by their markedincreased accumulation in the synovial lining of the inflamedjoint and their ability to produce numerous proinflammatorycytokines ... administered orally in two daily intakes. To evaluate the dose response of masitinib in DMARD-refractoryactive RA, dose ranging was performed by randomly assigningpatients to one of two initial...

Báo cáo y học: "Cytokines in the colon of a patient with Behçet’s disease" ppt

... Research & Therapy, in whichthey describe cytokine patterns of inflamed joints frompatients with Behçet’s disease (BD). The authors show thatneutrophils and T lymphocytes are involved in a Th1-skewedinflammatory ... terminated while TNF blockage was continued.Cytokines were evaluated in the resected colon by analyzingmRNA expression levels of cytokine genes as previouslydescribed [2]. Because of the extensive ... and highlyrelevant to the development of future immune-directedtherapy. Since the successful introduction of TNF blockers, itbecame apparent that Th1-cytokines might be key players in the immunopathology...

Báo cáo y học: "Ultrasound in the diagnosis of a median neuropathy in the forearm: case report" doc

... primary care physician was initially con-cerned about cervical root trauma given his history of degenerative disc disease and the nature of the injury, butan MRI and CT myelogram of the cervical ... patient'ssurgery. JY and GC helped to conceive of the study andparticipated in the editing process. MB performed the electrodiagnostic studies in the neurology clinic. Allauthors read and approved the final ... he presented to ourelectromyography (EMG) laboratory. On examination hehad profound weakness of the flexor pollicis longus andflexor digitorum profundus to the index and middle fin-gers, and...

Báo cáo hóa học: " Changes in the criticality of Hopf bifurcations due to certain model reduction techniques in systems with multiple timescales" pdf

... time scales in the analysis of these (k +l)-dimensional models by split-ting the system into the k-dimensional fast subsystem obtained in the singular limitε → 0of( 1) and known as the layer problem, ... Hopfbifurcation in the full system will persist in the singular limit as a Hopf bifurcation in the layer problem. It might be tempting to proceed by determining the nature of the Hopf bifurcation in the layer ... with the direction of v.A natural ﬁrst step in determining the criticality of the Hopf bifurcation in the fullsystem (14) might be to reduce the dimension of the model by setting the fast gatingvariables...

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