Báo cáo y học: "Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13" ppsx

... stimulation with increased PYK2 phosphorylation and production of MMP-1 3Chondrocytes respond to IL-7 stimulation with increased PYK2 phosphorylation and production of MMP-13. (a) Chondrocytes isolated ... addition to inducing matrix degrading enzymes directly, these cytokines can also act by stimulating production of additional proinflammatory cytokines....

Ngày tải lên: 09/08/2014, 10:23

... expression and function in chondrocytes. The objective of this study was to evaluate the expression of 15-lipoxygenase-1 and -2 in human articular chondrocytes, and to investigate the effects of their metabolites ... MMP-13 expression in chondrocytes. In addition to IL-1, the pro-inflammatory cytokines TNF-α and IL-17 also contribute to the pathogenesis of OA an...

Ngày tải lên: 09/08/2014, 14:20

... between synthesis and degradation is affected by age and is regulated by several factors produced by the synovium and chondrocytes, including cytokines, growth factors, aggrecanases, and MMPs ... significantly less with HA with a MW of 2.02 × 10 6 than HA with a MW of 9.5×10 5 [102]. Similarly, the histology of articular carti- lage and synovial tissue was significan...

Ngày tải lên: 09/08/2014, 01:21

... any sequence or structural homology. The common event is thought to be a conformational change, leading to lack of biological function or gain of toxic activity, and possibly, formation of amyloid ... closely connected to the so-called conformational diseases, many of which are hitherto incurable, and secondly, because it remains to be explained in physical terms (energeti...

Ngày tải lên: 17/03/2014, 23:20

... multicellular inflammatory process, including infiltration of lymphocytes and granulocytes into the articular cartilage, proliferation of synovial fibroblasts and macrophages and neovascularization of the synovial ... RO, Woody JN, Maini RN: The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid art...

Ngày tải lên: 09/08/2014, 08:23

... (HMFN0839)* 1-Acylglycerol-3-phosphate O-acyltransferase 9 [GenBank:NM_032717.3 ] 34 MTHFD2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [GenBank:NM_006636.3 ] 35 ... Institute of Allergy and Infectious Diseases (NIAID) due to its ability to initiate infec- tion via aerosol contact; the rapid onset of sepsis following the deve...

Ngày tải lên: 09/08/2014, 20:20

... Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia. 2 Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, ... prior proba bility of a heterozygous gen- otype to be specified [38,39]. We investigated the effect of varying this parameter , t, upon concordance of geno- typing array...

Ngày tải lên: 09/08/2014, 23:20

... channels, cause increased cytosolic calcium concentrations, and trigger erythrocyte apoptosis [55]. Induction of cell death of erythrocytes and the endocardium in zebrafish embryos by b-lapachone ... filter. TUNEL assay and histological analysis For the TUNEL assay to analyze apoptosis in the heart and erythrocytes, 48-hpf embryos were treated with either b-lapachone or DMSO...

Ngày tải lên: 10/08/2014, 10:20

... in the synovial fluid glucose concentration, and thus affect glucose delivery to the articular cartilage. Articular chondrocytes are highly glycolytic cells, requiring a steady supply of glucose ... effects of hyperglycemia in various cell types [17]. Moreover, ROS contribute to the pathogenesis of OA by mediating many of the effects induced by catabolic cytokines, such as...

Ngày tải lên: 09/08/2014, 14:21

... Veterinarians are often faced with the need to explain to their clients that it is not necessary, for example, to give away one’s cat during pregnancy and that if they follow a few very simple “rules”, ... They become infected by eating infected rodents, birds, or other small animals. Once oocysts are shed, they re- quire 1 to 5 days to sporulate and become infective. Cat...

Ngày tải lên: 03/11/2012, 11:06