Báo cáo y học: "Biomarker profiles in serum and saliva of experimental Sjögren''''''''s syndrome: associations with specific autoimmune manifestations" ppt

... 4% formalin before embedding in paraffin, sectioning, and staining with haematoxylin and eosin. Sections obtained from the kidneys were also stained using the periodic acid-Schiff staining technique. Evaluation ... presence of extraglandular disease manifestations with the situation in the salivary glands, it would be of interest to investigate further the involvement of kid...

Ngày tải lên: 09/08/2014, 10:23

... Simons, K. (1999) Clusters of glycolipid and glycosylphosphatidyl-inositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. ... digital imaging microscope. Detection of IL-2 stimulated tyrosine-phosphorylation of STATs IL-2 induced tyrosine phosphorylation of STAT3 (and STAT5) was followed by flow cytometry...

Ngày tải lên: 17/03/2014, 23:20

... symptoms may dominate and overlap the clinical manifestation of the disease. According to our results, the severity of physical anhedo- nia was associated with the severity of both positive and negative ... They had a mean of 12.6 (± 2.7) years of education, a mean duration of illness of 6.9 (± 7.6) years and a mean duration of hospitalisations of 0.4 (± 0.8) years....

Ngày tải lên: 08/08/2014, 21:20

... detectable in OA and RA synovial fluids and joint tissues, and is produced in vitro by both the synovium and chondrocytes in response to inflammatory cytokines [36]. MMP-14, produced principally by RA ... cytokines are produced in the synovium due to the influx of inflammatory cells from the circulation and synovial cell hyperplasia. The induction of proinflammatory cyto...

Ngày tải lên: 09/08/2014, 01:22

... yielded androgens with elevated levels of 5α-hydroxylated androgens in RA as compared with OA (general blockade of aromatiza- tion and support of 5α-hydroxylation, particularly in RA); 3. Similarly in RA and ... be proinflammatory. Therefore, therapy with androgens in RA could be a problem. This study was carried out in order to compare conversion products of andro...

Ngày tải lên: 09/08/2014, 06:23

... was weighed and injected intradermally at the base of the tail with 0.1 mL of emulsion containing 100 μg collagen, using a 1-mL glass tuberculin syringe with a 26-guage needle. Clinical scores The ... severity as grouped by average clinical score in individual animals. All four parameters progressively increased with increasing clinical scores in individual animals. Values ar...

Ngày tải lên: 09/08/2014, 10:22

... ZL, Qin YJ, He JW, Huang QR, Li M, Hu YQ, Liu YJ: Asso- ciation of polymorphisms in low-density lipoprotein receptor- related protein 5 gene with bone mineral density in postmenopausal Chinese ... DNA. Offspring of these mice carry these mutations. By screening thousands of offspring of mutagenized mice, mice with phenotypes generally caused by monogenic point mutations caused...

Ngày tải lên: 09/08/2014, 10:23

... anti-citrulline immunoblotting, which demon- strated an increase of citrullinated proteins in both inflamed synovium and brain tissue. Other interpretations, however, include the possibility that ... synovial array and 406 for their myelin array. This, of course, is a tiny fraction of the proteome and their choice had to be restricted to some of the antigens described as candi...

Ngày tải lên: 09/08/2014, 13:22

... risk of triggering an immune response finally culminating in synovitis. However, genetic susceptibility factors of the host are also playing an important role particularly in persistent infections ... analyses. BJ and JS participated in the design and coordination of the study, and drafted the manuscript. MR has assisted in writing the manuscript. AH and AS analyzed micr...

Ngày tải lên: 09/08/2014, 14:22

... active and latent infections are not binary but, instead, represent different ends of a continuum of disease [4]. is new paradigm of TB is largely based on studies in nonhuman primates, including ... determinants of susceptibility to infection. In particular, individuals with abnormalities in IFN-γ signaling path- ways are far more likely to develop progressive disease...

Ngày tải lên: 09/08/2014, 22:23